Vnitr Lek 2025, 71(8):525-527
Acute liver failure after unprofessional indication for albendazole
- Gastroenterologická ambulance Nemocnice Tanvald
Albendazole is a used medication for parasitic diseases and is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but manifestation of toxic damage is very rare. This case study presents the case of a middle-aged female patient evaluated for suddenly developed acute liver failure caused by several days of administration of higher doses of albendazole. The aim of the case report is to highlight that even potentially safe drugs can lead to serious adverse effects such as drug-induced liver injury (Drug induced liver injury, DILI).
Keywords: acute liver failure, albendazol, DILI.
Accepted: November 26, 2025; Published: December 15, 2025 Show citation
References
- Malik K, Dua A. Albendazole. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553082/
- LiverTox Clinical and Research Information on Drug induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases 2012- Albendazole [Updated 2021 Sep 18].
- Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole against parasites and cancers: Korean J Parasitol. 2021 Jun;59(3):189-225
Go to original source...
Go to PubMed... - Bilgic Y, Yilmaz C, Cagin YF, Atayan Y, Karadag N, Harputluoglu MMM. Albendazole Induced Recurrent Acute Toxic Hepatitis: A Case Report. Acta Gastroenterol Belg. 2017 Apr-Jun;80(2):309-311. PMID: 29560698.
- Fontana RJ. Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology. 2014 Apr;146(4):914-28. doi: 10.1053/j.gastro.2013. 12. 032. Epub 2013 Dec 31. PMID: 24389305; PMCID: PMC4031195.
Go to original source... - Zavoral M, Mařatkova gastroenterologie. Nakladatelství Karolinum: Praha 2021, 1077 s. ISBN 978-80-246-4974-8
- Martínek J, Trunečka P, a kol. Gastroenterlogie a hepatologie v algoritmech. Galén: Praha 2021. 571 s. ISBN 978-80-7492-590-0.
- Liao JM a kol. Front Pharmacol. 2023 PMID: 38027017
- Hůlek P, Urbánek P, et al. Hepatologie. 3rd ed. Grada Publishing: Praha 2018. 423 s. ISBN 978-80-271-0538-3.




