Trombofilie - editorial

Miloslava Matýšková

Vnitr Lek 2016, 62(12):958-959  

Takotsubo kardiomyopatie - další pokračování příběhu - editorial

Pavel Gregor

Vnitr Lek 2016, 62(12):960-961  

Pomalidomide in the treatment of multiple myeloma - own experience and overview of literature

Zdeněk Adam, Luděk Pour, Marta Krejčí, Eva Vetešníková, Viera Sandecká, Martin Štork, Zdeňka Čermáková, Eva Pourová, Sabina Ševčíková, Zdeněk Král, Jiří Mayer

Vnitr Lek 2016, 62(12):962-968  

In the Czech Republic, pomalidomide is covered for patients with multiple myeloma (in combination with dexamethasone), in the treatment of patients with relapsed and refractory multiple myeloma, who underwent at least 2 previous treatment schedules including both lenalidomide and bortezomibe, with disease progression despite the last therapy (i.e. during the therapy or within 60 days of its end), for whom the only remaining alternative of treatment (apart from pomalidomide) is that using high-dose dexamethasone, and who are not indicated for myeloablative treatment followed by a transplant of stem cells. At our centre pomalidomide was used in 53 patients...

Has been changed numbers and characteristics of patients with major amputations indicated for the diabetic foot in our department during last decade?

Vladimíra Fejfarová, Alexandra Jirkovská, Vladimír Petkov, Ludmila Řezaninová, Robert Bém, Michal Dubský, Veronika Wosková, Andrea Němcová, Jelena Skibová

Vnitr Lek 2016, 62(12):969-975  

Introduction:One of the most serious complications of the diabetic foot (DF) is a major amputation, which is associated with poor patient prognosis. The occurrence of major amputations may be influenced by a variety of factors including deep infection caused by resistant pathogens. The aims of our study were to compare the incidence of major amputations in podiatric center, characteristics of amputated patients with the DF and other factors contributing to major amputations in last decade. Methods:We included into our study all patients hospitalized for the DF in our center whose underwent major amputations from...

The common position of the Czech professional associations on the consensus of the European Atherosclerosis Society and the European Federation of Clinical Chemistry and Laboratory Medicine regarding investigation on blood lipids and interpretation of their levels

Vladimír Soška, Janka Franeková, Bedřich Friedecký, Antonín Jabor, Pavel Kraml, Hana Rosolová, Michal Vrablík

Vnitr Lek 2016, 62(12):1034-1040  

The aim of this opinion is to summarize and to comment the consensus of the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine, which covers two main areas: 1) whether it is necessary / required to be fasting or non-fasting before blood sampling for lipids measurement, and what are the changes in the concentration of blood lipids during the day; 2) What decision limits (cut off value) of lipids and lipoproteins should be reported from laboratories and what is the recommended procedure for people with extreme / critical blood lipid values. Following parameters are discused: total cholesterol, LDL cholesterol,...

The benefit of magnetic resonance for diagnosing cardiomyopathy and myocarditis

Michal Fikrle, Petr Kuchynka, Martin Mašek, Jana Podzimková, Jan Kuchař, Aleš Linhart, Tomáš Paleček

Vnitr Lek 2016, 62(12):976-984  

Magnetic resonance is becoming an increasingly used examination in cardiology, since it greatly improves the accuracy of diagnosing of many heart diseases. At present magnetic resonance is the gold standard in assessing the volumes of the heart chambers and the systolic function of both ventricles. The possibility of detecting tissue characteristics to refine the diagnostics of different types of myocardial pathology is of essential importance. The authors summarize in the article the present knowledge about the use of magnetic resonance of the heart in the field of myocardial disease, i.e. cardiomyopathy and myocarditis. In the first of this article,...

Thrombophilia

Ladislava Čingerová, Marta Kučeráková

Vnitr Lek 2016, 62(12):985-989  

Thrombophilia is a risk factor for thrombosis. The hematologists have come under pressure to initiate thrombophilia testing on an increasing number of patients. This article summarized practical aspects, with focus on whom to test, why to test, what to test, what not to test and clinical management consequences for individuals having been identified with a thrombophilia.

Coffee as hepatoprotective factor

Mária Szántová, Zuzana Ďurkovičová

Vnitr Lek 2016, 62(12):990-997  

The mind about the coffee did change upon the recent studies and metaanalysis of the last years. Consensual protective effect of coffee on the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocelullar carcinoma) was detected in experimental, clinical and large population studies together with decrease of mortality. Antioxidant, antifibrotic, insulinsensitizing and anticarcinogenic effect of coffee were detected. Modulation of genetic expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with decrease of proinflammatory...

Oral antidiabetic drugs in treatment of type 1 diabetes mellitus

Ludmila Brunerová, Jan Brož

Vnitr Lek 2016, 62(12):998-1003  

Review article summarizes current knowledge of the use of oral antidiabetics (approved for treatment of type 2 diabetes) in type 1 diabetic patients. Following drugs were tested: metformin, gliptines, analogues of GLP-1, glitazones, inhibitors of α-glukozidase and gliflozines. The latter seem to be the most perspective ones, however, more studies are warranted for definitive confirmation of their efficacy and safety. Current evidence-based results did not clearly show efficacy and safety of oral antidiabetics as adjuvant treatment in type 1 diabetic patients and thus, they still represent off-label treatment in this type of diabetes.

Von Hippel-Lindau syndrome - two sides of the same coin

Patrícia Páleníková, Monika Adamcová, Igor Šturdík, Beáta Ftáčniková, Lucia Copáková, Juraj Payer

Vnitr Lek 2016, 62(12):1004-1008  

Von Hippel-Lindau syndrome (VHL) is a rare genetic disease. Its incidence is 1 : 36,000, there is the familial occurrence in 80 % of cases , the remaining cases are de novo mutations. The disease is caused by the highly penetrant mutations in the VHL gene (3p25.3) and is characterized by the occurrence of benign and malignant neoplasms. The most common VHL tumors are the tumors of the retina, brain and spinal hemangioblastomas, renal cell carcinoma, pheochromocytoma, endolymfatic sac tumors and pancreatic tumors and cysts. The mean age of the VHL patients during the diagnosis is 20-40 years. The diagnosis can be confirmed by a positive family history...

Current position of new fixed-dose combination of tiotropium and olodaterol - its role in the treatment of chronic obstructive pulmonary disease in the Czech Republic

Vladimír Koblížek, Michal Svoboda

Vnitr Lek 2016, 62(12):1011-1020  

COPD is a serious pulmonary disease with rising global socioeconomic impact. From the perspective of the Czech Republic COPD was responsible for 21 000 acute hospitalizations and 3 500 deaths, mortality reaches 33/100 000 in 2015. Early stages of disease may be associated with a significant reduction of exercise capacity and the reduction of activities of daily living. Moreover early stages of bronchial obstruction are associated with the fastest lung function decline. Finally, early elimination of the risk of inhalation exposure is able to influence the course of the disease and to reduce its mortality. Most current treatment strategies and national...

Takotsubo cardiomyopathy: incidence, etiology, complications, therapy and prognosis

Milan Babický, František Holm, Miroslav Erbrt

Vnitr Lek 2016, 62(12):1021-1027  

Takotsubo syndrome is presented by acute heart failure and looks like acute coronary syndrome and truly mimics its clinical and ECG features. It is characterised by transient contractility disorder of mostly apical part of left ventricle without any presence of occlusive coronary disease. It is found in 1-2 % patients admitted to the hospital care for acute coronary syndrome. Prognosis is very excellent within complete recovery of left ventricle in several weeks. The etiology is unknown and therapy just symptomatic. Transient dynamic obstruction of left ventricle output tract can be sometimes present as well as hemodynamic instability and arrhythmias....

Lethal cases of bleeding to the upper gastrointestinal tract

Radek Matlach, Pavol Makovický, Peter Makovický

Vnitr Lek 2016, 62(12):1028-1033  

We report three lethal cases of bleeding to the upper gastrointestinal tract as immediate cause of death. The first two cases are in connection with homelessness. First is a male who was found dead in a railway station, seated on a bench with dried blood beneath him. The second is a male who was found lifeless in a wooden shelter, where upon the good will of the landowners, he lived. At autopsy, gastroduodenal ulcer disease with a damaged blood vessel at the ulcer base was found in both. The cause of death was stated as hypovolemic shock, arising from loss of blood from bleeding gastroduodenal ulcer disease. The third case shows a man with liver cirrhosis,...

Milan Kolář. Respirační infekce a jejich léčba

Vítězslav Kolek

Vnitr Lek 2016, 62(12):1049  

Martina Vašáková, Jaroslav Polák, Radoslav Matěj. Intersticiální plicní procesy

Vítězslav Kolek

Vnitr Lek 2016, 62(12):1049  

Vítězslav Kolek, Iva Vágnerová a kol. Kapesní průvodce ambulantní léčbou respiračních infekcí

Libor Fila

Vnitr Lek 2016, 62(12):1050  

Vítězslav Kolek a kol. Doporučené postupy v pneumologii

Zdeněk Merta

Vnitr Lek 2016, 62(12):1051  

Aleš Linhart, Tomáš Paleček. Echokardiografie u nemocných s plicní hypertenzí

Michael Aschermann

Vnitr Lek 2016, 62(12):1052  

Jiří Widimský, Jiří Widimský jr. Farmakoterapie hypertenze

Miroslav Souček

Vnitr Lek 2016, 62(12):1053  

Nefrologie je prostě amazing!

Petr Bidlo

Vnitr Lek 2016, 62(12):1042  

XIV. slovenské obezitologické dni s medzinárodnou účasťou. Nové pohľady na komplexný manažment pacienta s obezitou (2. časť)

Michal Pečík

Vnitr Lek 2016, 62(12):1043-1045  

Správa z XXI. kongresu Slovenskej kardiologickej spoločnosti

Ján Murín

Vnitr Lek 2016, 62(12):1046-1047  

Odešel doc. MUDr. Karel Janků, CSc.

Jiří Vítovec

Vnitr Lek 2016, 62(12):1041  

Korespondence ke článku. Charvát J. Kardiorenální syndrom - biomarkery a mediátory

Vnitr Lek 2016, 62(12):1048