Errata et corrigenda

Vnitr Lek 2015, 61(1):14  

Úvodní slovo předsedy České internistické společnosti, profesora MUDr. Richarda Češky, CSc., FACP, FEFIM. Česká interna a časopis Vnitřní lékařství v roce 2015

Richard Češka

Vnitr Lek 2015, 61(1):3-4  

POET2 - editorial

Eva Račická

Vnitr Lek 2015, 61(1):8-9  

Surprisingly old skeleton in the cupboard - editorial

Petr Sucharda

Vnitr Lek 2015, 61(1):10-12  

HevyLite™ - A new method for detection of monoclonal immunoglobulins - editorial

Jakub Radocha

Vnitr Lek 2015, 61(1):13-14  

Utility of Pneumonia Severity Index in hospitalized patients with pneumonia in intensive respiratory care units

Beáta Hutyrová, Petr Jakubec, Zdena Šindelářová, Jana Šubová, Kateřina Langová, Vítězslav Kolek

Vnitr Lek 2015, 61(1):15-23  

Introduction:The aim of this study was to evaluate the prognostic value of Pneumonia Severity Index (PSI) for prediction of 30-day mortality in patients admitted to intensive care unit (ICU) for community-acquired pneumonia (CAP). In patients with CAP, comorbidities, complications, and physical, laboratory, radiological and microbiological findings were evaluated relative to their prognosis. Patient and methods:In the study, 197 patients with CAP, hospitalised at ICU of Department of Respiratory Medicine, University Hospital Olomouc between 2008 and 2012, were enrolled. Risk factors according to PSI were assessed in all patients. Results:In...

POET2 registry: Comparison of annual direct medical costs of treating type 2 diabetes after addition of insulin NPH or insulin glargine to oral antidiabetic therapy in the Czech Republic

Milan Kvapil, Denisa Janíčková Žďárská, Josef Suchopár, Michal Prokeš, Jan Brož

Vnitr Lek 2015, 61(1):24-32  

Introduction:Poor glycemic control and the resulting development of complications of type 2 diabetes (DM2T) increase treatment costs. If adequate glycemic control cannot be achieved by lifestyle modifications and oral antidiabetic (OAD) therapy, initiation of insulin therapy is recommended. Cost effectiveness of basal insulins of the type NPH or glargine in combination with OAD for the treatment of DM2T was examined in a number of pharmacoeconomic studies. However, none of these studies were conducted in the Czech Republic. Therefore, the aim of the project POET2 was to compare annual direct medical costs of treating DM2T after addition...

Acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult - 2014 AS SMC Guidelines on the classification and diagnosis of aortic diseases

Peter Gavorník, Andrej Dukát, Ľudovít Gašpar

Vnitr Lek 2015, 61(1):72-80  

In addition to organovascular arterial ischemic diseases (cardiovascular, vasculovascular, neurovascular, extremitovascular, renovascular, genitovascular, bronchopulmovascular, mesenteriovascular, osteoarthromusculovascular, dermovascular, oculovascular, otovascular, stomatovascular etc.), aortic diseases contribute to the wide spectrum of arterial diseases: aortic aneurysms (AA), acute aortic syndromes (AAS) including aortic dissection (AD), intramural haematoma (IMH), penetrating atherosclerotic ulcer (PAU) and traumatic aortic injury (TAI), pseudoaneurysm, aortic rupture, atherosclerosis, vasculitis as well as genetic diseases (e.g. Turner syndrome,...

Therapeutic monitoring of amikacin and gentamicin in routine clinical practice

Ivana Kacířová, Milan Grundmann

Vnitr Lek 2015, 61(1):33-41  

Aminoglycosides constitute one of the oldest classes of antimicrobials. Despite their relative toxicity, mainly nephrotoxicity and ototoxicity, aminoglycosides are valuable in current clinical practice. They are bactericidal agents with activity against aerobic gram-negative infections and against gram-positive cocci when added to a cell wall active antimicrobial-based regimen (e.g. betalactams). Aminoglycosides have a concentration-dependent bactericidal effect and a long post antibiotic effect. There is accumulating evidence to show that large, single, daily doses (or more correctly, extended interval dosing) of aminoglycosides is associated with...

Association between asymptomatic hyperuricaemia and metabolic syndrome in the adolescents

Ivana Koborová, Radana Gurecká, Anna Hlavatá, Katarína Šebeková

Vnitr Lek 2015, 61(1):42-49  

In humans, uric acid represents a biologically active end-product of purine nucleotides. Several studies in children and adolescents documented an association between hyperuricaemia and the components metabolic syndrome. High intake of fructose-sweetened beverages might increase uricaemia, since fructose is the only saccharide which metabolism results in the formation of uric acid. Current knowledge does not allow distinguishing whether hyperuricaemia is causally related to the components of metabolic syndrome, or rather represents a marker of an enhanced risk, and poor outcome. No guidelines exist whether or not to treat asymptomatic hyperuricaemia...

Research of relations among sleep disorders, obstructive sleep apnoea, hypertension onset and hypertensive treatment - current or long-term trend?

Milan Sova, Eliška Sovová, Milada Hobzová, Monika Kamasová, Vítězslav Kolek

Vnitr Lek 2015, 61(1):50-55  

This paper is discussing recent findings about links between obstructive sleep apnea syndrome and arterial hypertension. It describes diagnostic approaches and also therapy of patients. It is describing options of pharmacological treatment and the influence of continuous positive airway pressure therapy on blood pressure level.

Tachycardia-induced cardiomyopathy

Jan Povolný

Vnitr Lek 2015, 61(1):56-59  

Cardiomyopathy is a heterogeneous group of diseases of heart muscle accompanied with impaired cardiac function. Tachycardia-induced cardiomyopathy (TIC) is caused by prolonged tachycardia leading to dilatation and systolic dysfunction with clinical manifestation of heart failure. This state is reversible after normalization of heart rate. The diagnosis is usually made retrospectively after normalization of heart rate and recovery of left ventricular function (LVF). More than 100 years after the first documented case (described in 1913 in a young patient with atrial fibrillation and symptoms of heart failure [25]) is still limited knowledge of pathophysiological...

The role of the assessment of heavy/light chain pairs of immunoglobulin in monoclonal gammopathies

Vlastimil Ščudla, Tomáš Pika, Jiří Minařík

Vnitr Lek 2015, 61(1):60-71  

The aim of the paper is to inform about the contribution of novel, highly sensitive analytic technique for the assessment of serum immunoglobulins (Hevylite™), enabling separate quantitative assessment of heavy/light chain pairs of immunoglobulin (HLC), i. e. the monoclonal ("involved") and polyclonal ("noninvolved") isotype including their ratio (HLC-r) in monoclonal gammopathies. We particularly target the characteristics of this technique, the comparison of its clinical contribution with standard methods used in the diagnostics, course and the detection of relapse and progression of the disease, as well as the stratification, assessment of...

Vladislav Hytych, Alice Tašková, Martina Vašáková et al. Plicní chirurgie v instruktivních kazuistikách

Ivan Čapov

Vnitr Lek 2015, 61(1):84  

Daniel Schwarz, Ladislav Dušek (eds) et al. Computer applications, systems and networks for medical education

Jan Žaloudík

Vnitr Lek 2015, 61(1):85  

Distribution of values of glycated haemoglobin in a population with type 2 diabetes: a project Valetudo

Milan Kvapil

Vnitr Lek 2015, 61(1):81-83  

Currently, there are no available data on distribution of the values of glycated haemoglobin in patients with type 2 diabetes in the Czech Republic. More frequent, efficacy and early application of new antidiabetic agents is limited by indication criterion which restricts the payment of this therapy for patients with poorly compensated diabetes defined by threshold value of 60 mmol/mol (6% IFCC). The study Valetudo analyzed distribution of glycated haemoglobin values in the random population of patients with type 2 diabetes and showed that within the critical range from 43 mmol/mol to 80 mmol/mol is the average frequency of patients from the whole...