Omluva

Petr Dítě

Vnitr Lek 2014, 60(2):177  

Úvodník po volbách aneb programové miniprohlášení předsedy ČIS

Richard Češka

Vnitr Lek 2014, 60(2):101-102  

VÝBOR ČIS pro funkční období 2014-2018

Vnitr Lek 2014, 60(2):102  

Orální infekce a revmatická onemocnění - editorial

Lenka Roubalíková

Vnitr Lek 2014, 60(2):105  

Septický/infikovaný trombus priechodu hornej dutej žily a pravej predsiene v súvislosti so zavedeným centrálnym žilným katétrom - editorial

Ján Murín, Michal Koreň, Juraj Papinčák, Soňa Kiňová

Vnitr Lek 2014, 60(2):106-107  

Septický/infikovaný trombus přechodu horní duté žíly a pravé síně se zavedeným centrálním žilním katétrem - editorial

Michal Šenkyřík

Vnitr Lek 2014, 60(2):108-109  

Assessment of left ventricular diastolic function by radionuclide ventriculography in patients with chronic heart failure and reduced ejection fraction

Jan Naar, Filip Málek, Otto Lang, Otakar Bělohlávek, Jana Vránová, Tomáš Mráz, Eva Mandysová, Petr Neužil

Vnitr Lek 2014, 60(2):110-113  

Study objective:To compare parameters of diastolic function as assessed by radionuclide ventriculography (RNVG) and Doppler echocardiography (ECHO) in the patients with chronic heart failure and reduced ejection fraction (HF REF). Patients and methods:RNVG and ECHO were performed on the same day in 40 patients with systolic chronic HF, NYHA II and III, with LV EF < 50 % and sinus rhythm, followed at tertiary HF clinic. Diastolic function was assessed by RNVG using parameters: PFR (peak filling rate [% SV/sec]), TFR - time to peak filling rate (ms), and by ECHO using pulse Doppler parameters: the peak Doppler velocities...

Dynamics of interleukin 6 levels in the patients with cardiogenic and septic shock and in a control group of patients with uncomplicated AMI

Jiří Pařenica, Jan Maláska, Jiří Jarkovský, Kateřina Helánová, Petr Jabandžiev, Jaroslav Michálek, Zuzana Veselková, Simona Littnerová, Lenka Kubková, Roman Gál, Pavel Ševčík, Monika Pávková Goldbergová, Jiří Litzman, Zdena Čermáková, Jindřich Špinar

Vnitr Lek 2014, 60(2):114-122  

Introduction:Cardiogenic shock (CS) is the leading cause of mortality in patients with acute myocardial infarction (AMI). Inflammatory response seems to be common response in patients with AMI, especially those with CS. We have therefore conducted a study to determine diagnostic and prognostic utility of interleukin 6 (IL6) levels in the cohort of patients with cardiogenic and septic shock (SS) and in a control group of patients with uncomplicated AMI. Methods:In this prospective study 71 patients fulfilled the inclusion criteria: 30 patients with cardiogenic shock, 21 patients with septic shock and 20 patients with ST elevation...

The place of JAK2 inhibitors in the treatment of myelofibrosis. An amendment to the recommendations for diagnosis and treatment of Ph negative myeloproliferations of the Czech group for Ph- myeloproliferative disorders (CZEMP)

Libor Červinek, Michael Doubek, Miroslav Penka, Jiří Schwarz

Vnitr Lek 2014, 60(2):158-163  

Primary myelofibrosis (PMF) belongs to Ph- myeloproliferative diseases. The only curative treatment is hematopoietic stem cell transplantation (HSCT). Conservative treatment options comprise supportive care, especially administration of red blood cell and platelet transfusions, and medication. Hydroxyurea, interferon α, anagrelide, corticosteroids, androgens, or inhibitors of angiogenesis (thalidomide, lenalidomide, pomalidomide) may be used for treatment of PMF, depending on the clinical stage and disease symptoms present. Also splenectomy or radiotherapy of enlarged spleen have palliative potential. JAK2 kinase inhibitors represent a...

MRI compatible cardiac pacemakers and implantable cardioverter defibrillators

Michal Šnorek, Alan Bulava

Vnitr Lek 2014, 60(2):123-127  

Implanted cardiac pacemaker (PM) or implantable cardioverter defibrillator (ICD) has been so far considered a contra-indication to magnetic resonance imaging (MRI). In the last few years MRI conditional cardiac implantable electronic devices have been marketed enabling patients undergo MRI under specific conditions. We present current state of the art and provide overview of available MRI conditional devices. Magnetic resonance imaging in these patients should be performed only in cases where the requested information can not be obtained using alternative imaging technique.

Oral infection and rheumatic diseases

Leona Procházková, Miroslav Souček

Vnitr Lek 2014, 60(2):128-133  

Periodontitis (PD) is one of the most common infectious diseases of dental attachment. From epidemiological studies there is known association of periodontitis with chronic diseases as for example diabetes mellitus, cardiovacular diseases, atherosclerosis or Crohn disease. In last decade there is an increasing evidence for association of rheumatoid arthritis (RA) and periodontitis also. RA and PD have some common genetic, environmental and immunopathological characters. Important aspect of reciprocal relationship is also ability to citrullination, which is innate to one of most important oral patogen - Porphyromonas gingivalis. Citrullination...

Renal denervation for treatment of arterial hypertension - the unanswered questions

Jitka Seidlerová, Jiří Koza, Ivo Bernat, Richard Rokyta, Vratislav Pechman, Jan Filipovský

Vnitr Lek 2014, 60(2):134-138  

Despite the extensive armamentarium of antihypertensive medication available, the control of hypertension remains poor. Therefore any possibilities of non-pharmacological treatment of resistant hypertension are welcome. Recently, close attention was paid to renal denervation. Present work summarizes the scientific reports and clinical trials related to this topic published so far and addresses the unanswered questions. Moreover, it also contains brief summary of authors' own experience with the method.

Therapy of Waldenström's macroglobulinaemia in the year 2014

Zdeněk Adam, Marta Krejčí, Luděk Pour, Eva Ševčíková

Vnitr Lek 2014, 60(2):139-157  

Therapy of Waldenström's macroglobulinaemia (WM) is indicated in patients with clinically relevant symptoms. Therapeutic plasmapheresis should be performed in cases with hyperviscosity. The intensity of chemotherapy should be adjusted to the degree of cytopenia. Monotherapy with rituximab is recommended in cases with severe cytopenia, also combination of rituximab with dexamethasone should be possible. Patients with symptomatic WM without severe cytopenia should received a rituximab-containing regimens, optimal variant is combination of rituximab + dexamethasone + alkylation drug (such as cyclophosphamide or bendamustine). Possible treatment combinations...

Isolated ventricular non-compaction: review article with a case-report example

Karel Vondrák

Vnitr Lek 2014, 60(2):164-170  

Isolated ventricular non-compaction (IVNC) is rare, genetically determined disorder characterized by prominent trabecularization of luminal side of the ventricular wall with deep recesses. The disease is believed to arise due to an in utero arrest of the compaction of the former loose meshwork of myocardial trabeculations. The symptoms of the disease include: heart failure, thromboembolic complications and arrhythmias. The course of the disease is variable ranging from patients with IVNC diagnosis as an incidental finding, to cases of severe heart failure and sudden cardiac death. This article brings an overview of the current state of knowledge on...

Catheter Related Septic Central Venous Thrombosis of the Superior Vena Cava and Right Atrium

Miroslav Bambuch, Jiří Latta

Vnitr Lek 2014, 60(2):171-176  

Catheter related septic central venous thrombosis (CR-SCVT) is an uncommon but serious complication related to central venous catheter use. Prolonged sepsis, late detection of the right diagnosis, difficult, long and costly treatment (and its own complications) threaten patients with further, potentially lethal complications. By the patients with an evidence of catheter sepsis, which persists despite targeted antibiotic therapy, it is important to think of this possible complication. Diagnosis can be determined by a combination of clinical, laboratory, microbiological and imaging techniques, from which is transesophageal echocardiography the most useful...

David Školoudík, Daniel Šaňák et al. Rekanalizační terapie akutní ischemické cévní mozkové příhody

Daniel Václavík

Vnitr Lek 2014, 60(2):177  

Ondřej Šimetka, Radovan Vlk, Martin Procházka. HELP syndrom

Petr Křepelka

Vnitr Lek 2014, 60(2):178  

Oznam/Oznámení

Vnitr Lek 2014, 60(2):179