Úvodní slovo předsedy České internistické společnosti, profesora MUDr. Richarda Češky, CSc., FACP, FEFIM. Česká interna a časopis Vnitřní lékařství v roce 2014

Vnitr Lek 2014, 60(1):3-4  

Úvodné slovo prezidentky Slovenskej internistickej spoločnosti, profesorky MUDr. Ivice Lazúrovej, CSc., FRCP. Quo vadis interná medicína?

Vnitr Lek 2014, 60(1):5-6  

Úvodní slovo šéfredaktora časopisu Vnitřní lékařství, primáře MUDr. Petra Svačiny. 60 let časopisu Vnitřní lékařství - retrospektiva, realita a perspektiva

Vnitr Lek 2014, 60(1):7-12  

Autoinflamace: patologický důsledek dysregulace zánětlivé reakce - editorial

Jindřich Lokaj

Vnitr Lek 2014, 60(1):17-19  

Vitamin D ve vztahu ke karcinomu hlavy a krku - editorial

Jana Neuwirthová

Vnitr Lek 2014, 60(1):20-21  

Terapie těžké sepse v roce 2013 - editorial

Jan Maláska

Vnitr Lek 2014, 60(1):22-24  

Familiar Mediterranean fever in Czech Republic

Anna Šedivá, Viktor Maňásek, Andrea Gřegořová, Pavlína Plevová, Nataša Toplak, Maruša Debeljak

Vnitr Lek 2014, 60(1):25-29  

Familiar Mediterranean fever (FMF) is a well defined autosomal recessive disease occurring mostly in Mediterranean regions. Here we present the experience from one center from Czech Republic, where we follow 4 families with patients with genetically proven FMF. Three out of these 4 families cluster to one limited region in Moravia, in the heart of Europe, without any linkage to Mediterranean origin. Furthermore, majority of these patients are heterozygots presenting with well defined typical clinical symptoms. Potential pseudodominant inheritance and/or epigenetic and environmental factors might influence clinical presentation of the disease.

Familial Mediterranean Fever - clinical picture, diagnosis and treatment

Tomáš Dallos, Denisa Ilenčíková, László Kovács

Vnitr Lek 2014, 60(1):30-37  

Familial mediterranean fever (FMF) is the most prevalent genetically determined autoinflammatory disease. FMF significantly decreases the quality of life and limits life expectancy due to the development of amyloidosis in affected individuals. Prevalence of FMF is highest in the south-eastern Mediterraneans. In other parts of the world, its occurance is often restricted to high-risk ethnic goups. In Central Europe, experience with FMF is scarse. As for Slovakia, we have reported the first cases of FMF in ethnic Slovaks only recently. Along with their complicated fates, this has lead us to compile a comprehensive overview of the clinical picture, diagnosis...

Food intake regulation - 2^nd part

Ludmila Brunerová, Michal Anděl

Vnitr Lek 2014, 60(1):38-50  

The review article summarizes the principles of hedonic regulation of food intake which represents the food intake independent on the maintenance of homeostasis. The theory describing hedonic regulation, so called Incentive Salience Theory, comprises three major processes: liking (positive attribution to food stimulus), wanting (motivation to gain it) and learning (identification of these stimuli and distinguishing them from those connected with aversive reaction). Neuronal reward circuits are the anatomical and functional substrates of hedonic regulation. They react to gustatory and olfactory (or visual) stimuli associated with food intake. A food...

Vitamin D in relation to head and neck cancer

David Kalfeřt, Marie Ludvíková, Martin Pešta, Ondřej Topolčan

Vnitr Lek 2014, 60(1):51-58  

Vitamin D was lately introduced as the important anti-cancer agent with therapeutic potential to be used in prevention and therapy of malignant tumors. Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Prognosis of this cancer is in most patients poor. In attempts to improve therapy of this cancer, contemporary research is focused on extension of the etiological and pathobiological aspects of cancerogenesis of HNSCC. This fact provoked us to summarize present scientific knowledge about etiopathological, chemopreventive and therapeutic role of vitamin D in head and neck squamous cancer and outline the direction...

International guidelines for management of severe sepsis and septic shock 2012 - comment

Jiří Chvojka, Martin Matějovič

Vnitr Lek 2014, 60(1):59-67  

Sepsis is one of the leading and grossly under recognized cause of death in the world. If not recognized early and treated promptly, sepsis leads to septic shock, multiorgan failure and death. This article summarizes recently updated international guidelines for management of severe sepsis and septic shock.

The emerging pathogenesis-based strategies for treating sepsis

Lenka Ledvinová, Vojtěch Danihel, Martin Matějovič

Vnitr Lek 2014, 60(1):68-72  

The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the pathogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high. However, the development of adjunctive anti-sepsis therapies has been challenging, with more than 30 unsuccessful drug trials. Fortunately, recent advances in our understanding of the sepsis pathophysiology revealed new pathogenic paradigms, and, thus, provided new exciting therapeutic concepts. In this review, we briefly discuss emerging pathogenesis-based...

Effect of alcohol consumption on cardiac electrophysiology

Markéta Bébarová

Vnitr Lek 2014, 60(1):73-79  

Potentially arrhythmogenic changes of the cardiac electrical properties induced by the alcohol consumption may be based both on the direct action of ethanol and its metabolites, acetaldehyde and acetate, on cardiac ionic channels and carriers, and on the indirect effect mediated namely by the released catecholamines, pH changes or electrolyte imbalance. Abnormalities in the cardiac function and structure may individually contribute as well. Owing to the deficient information and complexity of the concurrent factors, the concrete arrhythmogenic mechanism remains unclear. This review shows a comprehensive view on the current knowledge in the arrhythmias...

Familial Mediterranean Fever - First Experiences in Slovakia

Tomáš Dallos, Lucia Lukáčiková Gálová, Eva Macejková, Jozef Sedlačko, Nataša Toplak, Maruša Debeljak, Hasmik Sargsyan, Denisa Ilenčíková, László Kovács

Vnitr Lek 2014, 60(1):80-85  

Familial Mediterranean fever (FMF) is the most prevalent genetically determined autoinflammatory disease. FMF significantly decreases the quality of life and limits life expectancy due to the development of amyloidosis in affected individuals. Prevalence of FMF is highest in the south-eastern Mediterraneans. In other parts of the world, its occurance is often restricted to high-risk ethnic groups. In Central Europe, experience with FMF is scarse to none, as in the case of Slovakia, where no cases have been reported, so far. Herein we report the first five patients (3 adults and 2 children, 4 native Slovaks) in whom the diagnosis of FMF could be confirmed...

Ondřej Viklický et al. Predialýza

Josef Zadražil

Vnitr Lek 2014, 60(1):91  

Pavel Klener jr, Pavel Klener. Principy systémové protinádorové léčby

Vladimír Vonka

Vnitr Lek 2014, 60(1):92-93  

Vítězslav Kolek et al. Doporučené postupy v pneumologii

František Salajka

Vnitr Lek 2014, 60(1):93  

Vladimír Koblížek et al. CHOPN

František Salajka

Vnitr Lek 2014, 60(1):94  

Petr Ošťádal, Jan Bělohlávek. ECMO - Extrakorporální membránová oxygenace

Vladimír Lonský

Vnitr Lek 2014, 60(1):94  

Boris Krahulec, Ľubomíra Fábryová, Pavol Holéczy, Iwar Klimeš (eds) et al. Klinická obezitológia

Andrej Dukát

Vnitr Lek 2014, 60(1):95  

Nový občanský zákoník a poskytování zdravotních služeb

Tomáš Doležal

Vnitr Lek 2014, 60(1):90  

Oznam/Oznámení

Vnitr Lek 2014, 60(1):89  

Ohlédnutí za atestacemi z vnitřního lékařství - in medias res!

Martin Matějovič

Vnitr Lek 2014, 60(1):15-16  

Býti internistou

Zdeněk Susa

Vnitr Lek 2014, 60(1):86-87  

K 30. výročí úmrtí profesora Josefa Charváta

Štěpán Svačina

Vnitr Lek 2014, 60(1):88-89