Je syndrom polycystických ovarií součástí autoimunitních onemocnění? - editorial

J. Vrbíková

Vnitr Lek 2010, 56(5):368  

Problematika časné defibrilace - editorial

E. Kasal

Vnitr Lek 2010, 56(5):369  

Hormonal contraception and risk of venous thromboembolism

O. Ludka, J. Špinar, V. Musil, Z. Pozdíšek

Vnitr Lek 2010, 56(5):370-375  

Oral contraceptives increase the risk of thromboembolism. Recent studies have indicated that the risk of thromboembolic disease in users of combined oral contraceptive pills varies not only with estrogen dose, but also with the type of gestagen in pills with the same estrogen dose. We describe 8 women from our intensive care unit who developed a deep venous thrombosis while on oral contraceptives. The aim of this article is also to discuss other risk factors for the potential risk of venous tromboembolism in users of combined oral contraceptive.

Evaluation of cardiovascular high risk population in Specialists Ambulance: ESA

J. Žižka, M. Souček

Vnitr Lek 2010, 56(5):376-381  

Background:Arterial hypertension is the most common CV disease in the Czech Republic with estimated prevalence 35% among population aged 25 to 64 years. Although serious public health problem with significant medical and economic consequences the treatment of HT is currently unsatisfactory. Only 18.4% of patients with arterial HT reach goal BP. There are several factors responsible for this fact, among them low compliance of patients, low dosages of antihypertensive drugs used and low usage of the combination of antihypertensive drugs. Aim:To obtain following data from the specialists ambulances (internists and cardiologists)...

The prevalence of anemia and its impact on hospitalization mortality in patients with acute heart failure

R. Miklík, M. Felšöci, J. Pařenica, D. Tomčíková, J. Jarkovský, J. Špinar

Vnitr Lek 2010, 56(5):382-391  

Aim of study:To evaluate the influence of entry hemoglobin level on the hospitalization mortality of the patients admitted with AHF caused by 4 major etiologies - acute coronary syndrome with ST elevation (STEMI, n = 325) and without ST elevation (nonSTEMI, n = 210), decompensated chronic ischaemic heart disease (IHD, n = 206) and dilated cardiomyopathy (CMP, n = 88). Results:We analyzed 1,253 consecutive 1st-time hospitalizations of AHF patients of whom 1,212 had their entry hemoglobin known. Out of these, 829 subjects were of STEMI (1), nonSTEMI (2), IHD (3) and CMP (4) etiology and were included in further analyses. We...

The progress of autonomic parameters in patients after myocardial infarction with ST elevation

P. Lokaj, J. Pařenica, P. Kala, N. Honzíková, R. Lábrová, J. Špinar

Vnitr Lek 2010, 56(5):392-396  

The patients after myocardial infarction with ST elevation (STEMI) are endangered by the development inception of autonomic dysfunction, decreased baroreflex sensitivity, decreased heart rate variability, and increased blood pressure variability as a result of increased sympathetic activity and/or decreased parasympathetic activity. Thanks to direct angioplasty and optimal pharmacotherapy of coronary artery disease and heart failure, we didn't found any significant changes of these parameters within a one-year follow-up, and mortality due to cardiac etiology was very low in this group. Autonomic dysfunction and negative left ventricular remodeling...

Familial hypercalcemia and hypophosphatemia: importance in differential diagnosis of disorders in calcium-phosphate metabolism

I. Žofková

Vnitr Lek 2010, 56(5):397-401  

Hypercalcemia and hypophosphatemia are symptoms of two relatively rare hereditary diseases and are extraordinarily important from the standpoint of the differential diagnosis. Mutation in calcium sensing receptor gene (CaSR) clinically manifests as familial hypocalciuric hypercalcemia (FHH) or as the much more serious neonatal hyperparathyreosis. Hypercalciuric hypocalcemia is extremely rare. Prognosis for the most frequent mutations in the CaSR gene FHH is considered benign; nevertheless, if overlooked it can lead to an incorrect diagnosis of primary hyperparathyreosis, which has a fundamentally different prognosis and treatment. Familial hypophosphatemia...

A review of the effects of prolactin hormone and cytokine on the development and pathogenesis of autoimmune diseases

M. Fojtíková, M. Černá, K. Pavelka

Vnitr Lek 2010, 56(5):402-413  

Prolactin (PRL) is not only a pituitary hormone with important role in the reproduction but it also acts as a cytokine involved in the immune response. Prolactin is produced by many immune system cells that express the prolactin receptor (PRL-R). PRL is then able to affect local microenvironment of the immune system organs and contribute to maturation as well as functioning of the immune system cells. The role of PRL in the immune reactions is stimulating; its presence significantly increases the ability of the immune cells to proliferate and produce cytokines such as TNF-α, IFN-γ, IL-12, IL-1β. This effect results from activation...

Polycystic ovary syndrome and autoimmune diseases

J. Petríková, I. Lazúrová

Vnitr Lek 2010, 56(5):414-417  

Polycystic ovary syndrome (PCOS) is characterized by laboratory or clinical signs of hyperandrogenism with chronic anovulation and is currently one of the most frequent endocrinopaties in women of fertile age. Syndrome is associated with a variety of endocrine and metabolic disturbances and according to results of scientific work could be possibly associated with some autoimmune diseases. It seems that the prevalence of autoimmune tyroiditis is important among these patients. Recent studies reveal higher incidence of organ - non specific autoantibodies, but their clinical significance is unknown to date. Further studies are required to determine the...

The heart of a patient with type 1 diabetes

S. Lacigová, J. Meinlová, J. Gruberová

Vnitr Lek 2010, 56(5):418-426  

The heart of a patient with type 1 diabetes might be affected by ischemic heart disease, cardiovascular autonomic neuropathy as well as diabetic cardiomyopathy. These diseases might occur in isolation, although, more frequently, their effects are combined. Also, these co-morbidities have common risk factors. The aim of this review paper is to summarise the options currently available for the diagnostics, prevention and treatment of the listed heart diseases and, since the most frequent cause of death in the type 1 diabetes patients are cardiovascular diseases, to emphasise the fact that these patients should have cardiology assessment. To ensure clarity...

Gender differences in non-pharmacological treatment of chronic heart failure

A. Klabník, J. Murín, P. Kyčina

Vnitr Lek 2010, 56(5):427-433  

Prior studies demonstrated sex-related differences in many aspects of chronic heart failure (HF), and in the appropriate use, individual response or complication rates with non-pharmacological treatment, too. There is seasonal variability in morbidity and mortality of HF with significant gender differences, partially due to respiratory diseases, which may be potentionally preventable by vaccination. Quitting smoking is associated with substantial decrease in morbidity and mortality in HF patients which is similar in magnitude to the effect of an appropriate beta-blocker use. Yet little emphasis has been placed on smoking cessation strategies in women...

ILCOR recommendation on signing of automated external defibrillators (AEDs)

A. Truhlář

Vnitr Lek 2010, 56(5):434-438  

Early defibrillation is a determinant of survival in both out-of-hospital and in-hospital cardiac arrests from ventricular fibrillation and pulseless ventricular tachycardia. The review summarizes importance of early defibrillation with automated external defibrillators (AED) and presents the International Liaison Committee on Resuscitation (ILCOR) recommendation for universal AED sign. The aim of the recommendation is to unify the AED signs worldwide and to spread the knowledge of this. The public in general, but healthcare professionals particularly, should be able to recognize AED location and use the device immediately in case of cardiac arrest.

Müllerová D et al. Obezita - prevence a léčba. Praha: Mladá fronta, a.s. 2009. 261 stran. ISBN 978-80-204-2146-3

Hana Svačinová

Vnitr Lek 2010, 56(5):444  

Cetkovský P, Kouba M et al. Diferenciální diagnostika plicních infiltrátů a pokroky v léčbě mykotických infekcí u imunokompromitovaných pacientů. Praha: Triton 2009. 259 stran. ISBN 978-80-7378-343-1

Jan Starý

Vnitr Lek 2010, 56(5):444-445  

Prof. MUDr. Jiří Widimský, DrSc., FESC, FAHA, člen České lékařské akademie, se dožívá 85 let

Miroslav Souček

Vnitr Lek 2010, 56(5):442-443  

XXIX. dni mladých internistov Martin, Slovenská republika, 27.-28. 5. 2010. Zborník abstraktov

Vnitr Lek 2010, 56(5):447-478  

Angiologické dny 2010

J. Spáčil

Vnitr Lek 2010, 56(5):439-441