Vnitřní lékařství, 2006 (vol. 52), issue 3

Editorial

PET - možnosti a limitace - editorial

O. Bělohlávek

Vnitr Lek 2006, 52(3):203-204

Molekulární biologie a diabetes: kam teď? - editorial

M. Haluzík

Vnitr Lek 2006, 52(3):205-206

Original articles

The value of fluorodeoxyglucose positron emission tomography in multiple myeloma

Z. Adam, K. Bolčák, J. Staníček, L. Pour, R. Hájek, M. Krejčí, J. Prášek, J. Neubauer, Y. Mareschova, J. Vorlíček

Vnitr Lek 2006, 52(3):207-214

Aim:The aim of this study was investigate the appearance of multiple myeloma on flurorine - 18 fluorodeoxyglucose positron emission tomography (FDG-PET). Furthermore the accuracy of FDG-PET in detecting myeloma lesions and its influence on patient's management were evaluated. Methods:Altogether 50 patients, 13 patients with newly diagnosed multiple myeloma with negative radiographs, 4 patients with solitary plasmocytoma, 27 patients in remission with suspected relapse and 6 patients with monoclonal gammopathy of unknown significance (MGUS) with suspicion for multiple myeloma or other malignancy underwent FDG-PET examination....

Effect of administration of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endo-toxemia, liver function and minimal hepatic encephalopathy in patients with liver cirrhosis

J. Lata, J. Juránková, V. Příbramská, P. Frič, M. Šenkyřík, P. Dítě, R. Kroupa

Vnitr Lek 2006, 52(3):215-219

The purpose of the study was to verify effects of Escherichia coli Nissle (Mutaflor) on intestinal colonisation, endotoxin levels, hepatic encephalopathy and liver function in patients with liver cirrhosis. The study involved 39 patients (22 taking Mutaflor and 17 taking placebo). Even though the number combination test showed extended reaction time in patients with described minimal hepatic encephalopathy the drop was not significant in the trend evaluation. However, the treated group displayed significant improvement of intestinal colonisation (p < 0.001) and a trend towards significant reduction of endotoxin levels on day 42 (p = 0.07) and improvement...

Effect of high-dose chemotherapy with subsequent transplantation of blood-forming cells on left ventricle function in patients with malignant lymphomas treated with doxorubicin in primary chemotherapy

L. Elbl, I. Vášová, M. Krejčí, M. Navrátil, I. Tomášková, F. Jedlička, V. Chaloupka, J. Mayer, J. Vorlíček

Vnitr Lek 2006, 52(3):221-231

Purpose of study:The authors examined whether high-dose chemotherapy with hematogenic tissue transplantation might negatively affect function of left ventricle (LV) in oncology patients with malignant lymphomas initially treated with conventional chemotherapy consisting of doxorubicin (DOX) in contrast to patients treated without the transplantation in medium-term follow up. Patients and methodology:The follow up group included 77 patients (39 women/38 men) at the age of 36 ± 15 (median 30, 16-67 years). All 77 patients were treated with initial chemotherapy with DOX, 22 out of that group later received high-dose chemotherapy...

Comparison of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma

V. Ščudla, M. Budíková, T. Pika, J. Minařík, M. Zemanová, J. Bačovský, V. Heincová, Česká myelomová skupina

Vnitr Lek 2006, 52(3):232-240

Purpose of study:The study focuses on evaluation of differences in serum levels of selected biological indicators in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM), primarily from the viewpoint of potential asset to clinical practice. Patients and methodology:The analyse set of 96 patients consisted of 30 individuals with MGUS and 66 patients with MM examined in the context of the disease diagnosis before therapy commencement. Serum levels of the assessed parameters were examined with the help of radio-enzymatic method (thymidinkinase), radioimmunoanalysis (β₂-micro-globulin,...

Non-invasive ventilation support in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD)

P. Matuška, O. Pilařová, Z. Merta, J. Skřičková

Vnitr Lek 2006, 52(3):241-248

Aim:To verify that the use of noninvasive ventilatory support in acute exacerbation of chronic obstructive pulmonary disease leads to decreasing the number of deaths, shortening in-hospital stay and decreasing number of endotracheal intubations (ETI). Setting:The study was conducted at a respiratory department's ICU in 2002-2004. Methods:Patients hospitalized on ICU with acute exacerbation of COPD, respiratory acidosis and global respiratory failure were randomised into two groups. Patients in group A were treated by conservative medical therapy (oxygen, bronchodilator, corticosteroid), patients in group B received...

Reviews

Asymmetric dimethylarginine - a novel cardiovascular risk factor

R. Široká, R. Cibulka, D. Rajdl, J. Racek

Vnitr Lek 2006, 52(3):249-255

Understanding metabolism of nitric oxide (NO), signal molecule releasing from endothelial cells and influencing vascular tone, belongs to the most remarkable knowledge of last ten years. NO increases vascular tone, inhibits adhesion of monocytes and leukocytes to the vascular endothelium and reduces atherogenic process. Low NO level is one of pathogenic factors starting cardiovascular diseases. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of enzyme NO synthase, enzyme catalyzing NO production from arginine. This article gives a brief overview of contemporary state of the relation between ADMA and cardiovascular diseases. Increased...

Immunoglobulin A and renal diseases

K. Matoušovic, J. Mestecky, M. Tomana, J. Novak

Vnitr Lek 2006, 52(3):256-262

Immunoglobulin A (IgA) is a dominant immunoglobulin of the mucosal surfaces, but it is also present in plasma. In men and in hominoid primates it occurs in two subclasses: IgA1 and IgA2. Circulating IgA is mostly IgA1 monomer, secretory IgA is mostly dimer or tetramer with varying content of IgA1 and IgA2 on individual mucosal surfaces. Its main physiological function is a defence of the mucosal surfaces against infection. It binds either specifically to bacterial antigens or through its O-linked glycosidic chains, it binds to the lectins of bacterial cells and thus protects mucosal surfaces against bacterial adhesion and infection. On each...

Hypertension in pregnancy

R. Cífková

Vnitr Lek 2006, 52(3):263-270

Hypertension in pregnancy is one of the main causes of maternal, fetal and newborn morbidity and mortality in civilised countries. Current recommendations of the European Society for Hypertension prefer definition of hypertension in pregnancy based on absolute values of blood pressure, i.e. systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg. The most important task of classification of hypertension in pregnancy is to distinguish whether hypertension comes before pregnancy (the so called pre-existing hypertension) or whether it is a pregnancy-induced condition (the so called gestational hypertension). Pre-existing hypertension...

Case reports

Extension of QT interval as a consequence of risk factor accumulation - case study

M. Šišáková, O. Toman, A. Floriánová, J. Kadlecová, K. Chroust, I. Papoušek, J. Špinar

Vnitr Lek 2006, 52(3):271-273

Background:Many non-cardiovascular drugs have a potential for QT interval prolongation. This phenomenon can be related to occurence of ventricular tachycardia torsades de pointes, syncopi and even sudden death. Description of the case: A female patient treated with antracycline cytostatics developed a depression of left ventricle ejection fraction. At the same time she was administered 2 common drugs with proarrhythmic potential - terfenadine and itraconazole. In this patient hypokalemia also occured. Combination of the above mentioned risk factors led to QT interval prolongation and frequent ventricular tachycardias torsades de pointes...

Glibenclamide site of in insuline: a new chance for MODY 3 type diabetes patients: case report

L. Brunerová, L. Trešlová, Š. Průhová, J. Vosáhlo, J. Brož, J. Lebl, M. Anděl

Vnitr Lek 2006, 52(3):275-279

MODY 3 belongs to monogenic forms of diabetes mellitus and is caused by monoallelic mutation in gene for transcription factor HNF-1α, essential for regulation of β-cell function. Clinical presentation of MODY 3 is similar to that of type 1 diabetes. Although MODY 3 patients are not threatened by ketoacidosis, tight metabolic control is important for prevention of chronic diabetic complications. In the sibbling pair diabetes was manifested by osmotic symptoms resulting from hyperglycaemia at the age of 18 years (brother) resp. 15 years (sister) and both of them started being treated with intensified insulin treatment. Metabolic control...

From scholarly literature

Sninčák M. Artériová hypertenzia: súčasné klinické trendy. Košice: TypoPress 2005. 284 stran. ISBN 80-89089-39-9

Andrej Dukát

Vnitr Lek 2006, 52(3):285

I. Žucha, I. Hulín: Myšlienky. Bratislava: Slovak Academic Press 2006. 255 stran. ISBN 80-89104-75-4

Ivan Ďuriš

Vnitr Lek 2006, 52(3):285-286