[Liver transplantation finally available also for our patients with chronic hepatitis B virus infection].

P Husa

Vnitr Lek 2004, 50(12):881-883

[Liver transplantation for chronic hepatitis B].

P Trunecka

Vnitr Lek 2004, 50(12):883-886

[The activation of haemostasis during radiofrequency catheter ablation].

P Parízek, L Haman, J Malý, M Pecka, M Hodac, J Bukac, P Stránský, R Malý, J Duda, M Pleskot

Vnitr Lek 2004, 50(12):887-893

The aim of the study was to investigate chosen haemostasis activation markers during electrophysiologic study (EPS) with consequent radiofrequency catheter ablation (RFA). Sixty-three patients were studied prospectively. Indications for EPS and RFA were supraventricular tachycardias with the arrhythmogenic substrate located in the right atrium. Blood samples were drawn 24 hours before the procedure (T -1), at the beginning of the procedure (T0), at the end of EPS (T1), 30 minutes after completion of RFA (T2), and 24 hours after the procedure (T3). To study coagulation, fibrinolytic and platelet activation were measured concentrations of thrombin-antithrombin...

[Relation between diabetes compensation, albuminuria and biochemical parameters and the results of stress myocardial SPECT in asymptomatic type 2 diabetics].

J Charvát, K Michalová, K Táborská, J Chlumský, M Kvapil, J Vojácek

Vnitr Lek 2004, 50(12):894-900

The patients with diabetes mellitus and another risk factors have significantly higher risk to suffer from ischemic heart disease. Myocardial stress SPECT represents the examination which correlates very well with the results of selective coronary angiography even in asymptomatic diabetic patients. The aim of our study was to evaluate the relation of SPECT result to diabetes compensation, presence of micro/macroalbuminuria, blood level of fibrinogen, CRP, homocysteine and uric acid. Out of 126 diabetic 2. type abnormal SPECT has been found in 33 (26%). Fasting blood sugar (9.3 +/- 1.4 mmol/l in patients with abnormal SPECT vs. 9.7 +/- 1.9 mmol/l in...

[Factors participating in development of bleeding varices in portal hypertension. Part II: Possible impact of kidney damage and malnutrition, mortality].

J Lata, L Husová, J Juránková, M Senkyrík, P Dítě, M Dastych jun, M Dastych, R Kroupa

Vnitr Lek 2004, 50(12):901-906

An acute bleeding from oesophageal varices as a result of portal hypertension is a frequent and serious complication of liver cirrhosis. The development of oesophageal varices and their rupture depends on the portal pressure. However, a range of other factors can contribute to a development of bleeding and its negative prognosis. A sample of 46 patients admitted for the acute bleeding has been compared to 48 cirrhosis patients hospitalised for other conditions in this work. There were significantly higher levels of nitrogenous matters in bleeding patients (urea 14.1 mmol/l vs. 7.78 mmol/l, p < 0.01, creatinine 129.8 micromol/l vs. 106.04 micromol/l,...

[Liver transplantation for hepatitis B].

V Mejzlík, P Studeník, J Ondrásek, M Kuman, P Pavlík

Vnitr Lek 2004, 50(12):907-910

Up to now the outcomes of liver transplantation in patients with chronic viral hepatitis B have not been very good because the recurrence of viral hepatitis in the graft has been high and resulted in a high early graft failure of liver transplant recipients. However, the administration of a combined therapy with lamivudine and hyperimmune anti-HBs globulin has led to a marked improvement in transplantation results and an increase in the number of liver transplantations for this indication. Four men (aged 47 to 55 years) underwent liver transplantation for cirrhosis, caused by chronic viral hepatitis B, at our centre. All were HBsAg carriers. They were...

[Seroprevalence of Helicobacter pylori in rheumatoid arthritis and its relationship to pharmacotherapy].

I Rybár, J Rovenský, P Masaryk, F Mateicka, I Révayová

Vnitr Lek 2004, 50(12):911-916

GOAL: To find out a serology prevalence of Helicobacter pylori (Hp) infection in patients suffering from rheumatoid arthritis (RA) and to investigate its relationship to pharmacotherapy modes.METHOD: To determine Hp IgG class and IgA class antibodies by ELISA method in hospitalised patients with active RA according to ACR criteria (1987).RESULTS: 137 patients with RA were examined--20 men, 117 women, an average age was 54.6 +/- 13.1, an average length of RA in these patients was 12.46 +/- 9.75, positive RF/LFT had 88% of patients. Hp ELISA IgG antibodies were confirmed in 57% (78/137) of patients with RA, Hp ELISA IgA antibodies were confirmed...

[Activated factor XII in patients with hyperglycaemia and dyslipidaemia].

R Průsa, J Zadina, J Bronský

Vnitr Lek 2004, 50(12):917-922

BACKGROUND: Increased plasma levels of activated factor FXII (FXIIa) are associated with increased risk of atherosclerosis and coronary heart disease. There are increased levels of FXIIa in patients with dyslipidaemia and also elevated levels of FXIIa have been reported in patients with diabetes mellitus. No studies were reported whether FXIIa correlates rather with plasma glucose levels or with other metabolic markers like hypertriacylglycerolemia.METHODS: We measured plasma FXIIa levels, triacylglycerols, uric acid and glucose in a group of 158 hyperglycaemic patients with P-glucose more than 8 mmol/l and variable serum lipid parameters [cholesterol,...

[A relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women].

R Mottl, J Cerman

Vnitr Lek 2004, 50(12):923-929

UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive.METHODS: In our study participated 50 obese women and 20 obese men both with BMI over 27 kg/m2. Insulin resistance was calculated using HOMA insulin resistance index (HOMA-IR) that is based on fasting glycaemia and basal insulin levels.RESULTS: The negative correlation between DHEAS and HOMA-IR was found in the whole group of obese women but...

[Angiogenesis and antiangiogenic cancer therapy].

L Pour, R Hájek, T Buchler, V Maisnar, L Smolej

Vnitr Lek 2004, 50(12):930-938

Physiologic angiogenesis takes place during tissue growth and repair, during the female reproductive cycle, and during fetal development. Angiogenesis is also required for tumor growth and metastasis and, therefore, represents an exciting target for cancer treatment. Angiogenesis is a complex process that is tightly regulated by pro- and antiangiogenic growth factors. Pathologic angiogenesis is characterized by either excessive (eg. cancer) or inadequate (eg. coronary artery disease) neovascularization. Avascular tumors are severely restricted in their growth potential because of the lack of a blood supply. For tumors to develop in size and metastatic...

[Huge sinus of Valsalva aneurysm in patient with cystic medial necrosis of the aorta].

P Tousek, J Krupicka, H Línková, Z Straka, L Koldová, P Widimský

Vnitr Lek 2004, 50(12):939-942

In this case we present a patient with unruptured non-coronary sinus of Valsalva aneurysm associated with diverse clinical findings, caused by acquired degenerative changes of the aortic wall. A previously healthy 36-year-old female was admitted to the neurological clinic of our hospital having suffered from an episode of unconsciousness prior to admission, with accompanying seizures. For the preceding two months she had also been suffering from dyspnoea and palpitation. Neurological examination, computed tomography of the head and electroencephalography were with normal findings. Thereafter, due to paroxysm of supraventricular tachycardia she was...