[Predictors or statistics versus individual effects of chemotherapy].

J Zaloudík

Vnitr Lek 2002, 48(11):1001-1003

[Liver biopsy in chronic hepatitis virus C infection--unnecessary, useful or useless?].

P Husa

Vnitr Lek 2002, 48(11):1004-1006

[Editorial referring to (in general) to the article: Hauer D. et al: Thyroid disease in pregnant women and its development after childbirth].

Z Límanová

Vnitr Lek 2002, 48(11):1007-1008

[Ethylene glycol poisoning].

S Sulková

Vnitr Lek 2002, 48(11):1009-1010

[Gastrointestinal hemorrhage and endoscopic findings in patients with chronic kidney failure].

J Závada, S Sulková, M Lukás

Vnitr Lek 2002, 48(11):1011-1016

Case-control study comparing 81 patients with chronic renal failure (CRF) with 58 patients without renal disease who were evaluated by endoscopy of upper and/or lower gastrointestinal tract (GIT) for gastrointestinal bleeding or dyspepsia. The success of endoscopic examinations was the same in both groups. Patients with CRF more often underwent endoscopic examination because of gastrointestinal bleeding and they presented more often by hematochezia. Patients with CRF were more often found to have hemorrhagic gastropathy or duodenopathy and angiodysplasia of upper and lower GIT. However, duodenal ulcer was significantly more common in the control group...

[Effect of transjugular portosystemic shunt on insulin resistance].

J Stefánková, V Safka, T Fejfar, P Hůlek, I Dresslerová, A Krajina

Vnitr Lek 2002, 48(11):1017-1024

UNLABELLED: Patients with cirrhosis of the liver suffer from hyperinsulinaemia and a certain degree of insulin resistance. More frequently than in the rest of the population they have diabetes. Transjugular intrahepatic portosystemic shunts (TIPS) as a therapeutic method in complications of portal hypertension lead to rapid haemodynamic changes in the liver. The objective of the submitted work was to assess whether TIPS has an impact on insulinaemia and whether it influences insulin resistance in patients with cirrhosis of the liver.GROUP AND METHODS: The authors evaluated a group of 22 patients with cirrhosis of the liver (10 diabetics and 12...

[Importance of liver biopsy in chronic hepatitis C virus infection].

P Urbánek, J Vedralová, Z Marecek, M Brodanová, E Procházková-Francisci, R Brůha, J Petrtýl, M Kaláb

Vnitr Lek 2002, 48(11):1025-1030

INTRODUCTION: The importance of liver biopsy and knowledge of the histological activity of liver les on in chronic hepatitis C virus (HCV) infections is widely discussed recently. There are attempts to find an alternative evaluation which will make it possible to avoid liver biopsy. The crucial question in patients with chronic HCV infection is to differentiate patients with already developed liver cirrhosis from those with chronic hepatitis.OBJECTIVES: 1. To evaluate the impact of the calculation of the discrimination score of liver cirrhosis (DSC) for prediction of liver cirrhosis in the histological assessment. 2. To assess the correlation of...

[Incidence of risk factors and vascular complications in patients with newly diagnosed type 2 diabetes mellitus].

B Krahulec, J Vozár,

Vnitr Lek 2002, 48(11):1031-1038

UNLABELLED: The objective of the investigation was early detection of risk factors of diabetes and/or atherosclerosis and the prevalence of vascular complications of diabetes in newly diagnosed patients with type 2 diabetes in the Slovak Republic.PATIENTS AND METHODS: In the Slovak detection programme of vascular complications participated 40 diabetological out-patient departments. In the course of one year (from the beginning of June 1999 to the end of May 2000) in a total of 3424 newly diagnosed patients with type 2 diabetes, aged under 70 years the case-history was recorded, focused on risk factors of diabetes and atherosclerosis, on the patients'...

[Parenteral glutamine does not improve the nutritional status in patients during high-dose chemotherapy and autologous peripheral stem cell transplantation].

P Benes, R Pytlík, E Chocenská, M Paťorková, J Klepetár, B Procházka, E Gregora, T Kozák, M Anděl

Vnitr Lek 2002, 48(11):1039-1048

BACKGROUND AND AIM: High-dose chemotherapy is aggressive treatment modality adversely affecting both energy/protein demands and oral intake/resorption of nutrients. Aminoacid glutamine is known for its' proteoanabolic effect and as an energy source for enterocytes and immune system. Nutritional parameters have been studied in a controlled, randomised, double-blinded trial of parenteral glutamine supplementation of autologous stem cell transplant patients.METHODS: Forty consecutive patients with haematological and solid cancer and multiple sclerosis were treated from 1999 to 2001 by high-dose chemotherapy with autologous stem cell transplantation....

[A questionnaire survey of tolerance and adverse effects of clodronate (Bonefos) in patients with multiple myeloma].

I Lastůvková, Z Adam

Vnitr Lek 2002, 48(11):1049-1053

The tolerance of Bonefos was assessed by means of a questionnaire completed by 87 (76.3%) of 114 addressed patients with multiple myeloma who use this drug for prolonged periods. Of 54 patients treated by the oral form 50% were quite free from complaints, and complaints associated with more than half the administrations was reported by 7.4% patients. Of 33 patients treated by infusion 57.6% were quite free from complaints and 9.0% patients had complaints after more than half the administrations. The most frequent undesirable effect reported by the addressed patients were digestive complaints. The latter were reported by 47.3% of the total number of...

[Diagnosis and therapy of ethylene glycol poisoning--analysis of 20 patients].

M Mydlík, K Derzsiová, P Mizla, A Böör, E Macingová, L Slosarcíková

Vnitr Lek 2002, 48(11):1054-1059

The paper presents a retrospective analysis of 20 patients with acute ethylene glycol intoxication who were treated from 1972 to 2001 in the Dialysis Centre of the IVth Medical Clinic and from 1997 at the L. Pasteur Nephrological Clinic of the Faculty Hospital and Safarík Medical Faculty in Kosice. The ethylene glycol intoxication was manifested by neurological symptoms, extreme metabolic acidosis, acute toxic hepatitis and acute renal failure. Laboratory examination revealed oxaluria in 17 patients and leukocytosis in all patients. Percutaneous renal biopsy was made for differential diagnostic or forensic reasons in the convalescent stage of acute...

[Thyroid disease in pregnant women and its development after childbirth].

D Hauerová, R Pikner, O Topolcan, D Mrázová, L Holubec, L Pecen

Vnitr Lek 2002, 48(11):1060-1064

OBJECTIVE: To assess the incidence of post-partum thyropathies in women with positive antibodies against thyroid peroxidase in the second trimester of pregnancy.MATERIAL AND METHODS: Based on a cross-sectional study of the prevalence of abnormal laboratory parameters of thyroid function in a group of 650 pregnant women in the second trimester of pregnancy the authors invited for subsequent clinical examination and repeated controls women with elevated antibodies against thyroid peroxidase (antiTPO) above 60 mU/l (1). The group comprised 75 pregnant women, incl. 44 (58.7%) who attended the examination. After delivery the authors examined the serum...

[Effect of demographic, anamnestic and clinical factors on hospital mortality in patients with myocardial infarct].

S Cagán, S Wimmerová, I Besedová, T Trnovec

Vnitr Lek 2002, 48(11):1065-1074

The objective of the work was to analyze local priority data on the possible effect of demographic, anamnestic and clinical factors in a non-selected population of 3123 patients with acute myocardial infarction (AIM) on the hospital mortality (HM). 12.6% patients with AIM died in hospital. The mean age of those who died was 71.92 years. There were more than 4 times more patients above 64 years than 64-year-old ones or younger ones who died. The mortality rate of 64-year-old patients and younger ones (5.2% is significantly lower than in patients above 64 years (19%). The mortality rate of patients above 74 years was 27.1%. Important correlations of...

[Gastropathies caused by non-steroidal antirheumatic agents].

P Dítě, I Novotný

Vnitr Lek 2002, 48(11):1075-1081

Non-steroid antirheumatics are among very frequently prescribed drugs. They can be, however, associated with the development of serious and undesirable effects on the digestive tract. Therefore at present therapeutic procedures are sought which will restrict the negative effect of drugs on the mucous membranes of the stomach, duodenum and gut in general, incl. new forms of non-steroid antirheumatics with a "sparing" effect on the gastroduodenal mucous membranes. This group of drugs includes preparations with a so-called preferential or specific effect on cyclooxygenase 2 (COX-2). This enzyme is of fundamental importance for the development of mucosal...

[Primary hemochromatosis].

S Kinová, M Boca, D Buzgová, S Galbavý, S Stvrtina

Vnitr Lek 2002, 48(11):1082-1086

Authors describe in the case report a development of the primary hemochromatosis. At the time of the diagnosis in 1979 from organ complication the liver fibrosis and secondary diabetes mellitus were presented. Patient was treated with the venepunctions and with desferoxamine. In the 1998 the primary hepatocellular tumor was found and resected. Instead of the chemotherapy occurred the progression of the disease with multiple metastases and liver insufficiency and 66-years old patient died 19 months after surgery in the 20th year of the disease.