[Effect of pancreatic substitutes on fecal and serum elastase and on pain in patients with chronic pancreatitis].

S Aleryani, I Duris, J Payer, M Huorka, T Tesar, H Kratochvíĺová, P Ondrejka

Vnitr Lek 2000, 46(5):263-267

Views on the existence of a negative feedback between pancreatic secretion and intraduodenal of proteases in humans are controversial. The objective of the study was to find out whether enzyme substitution will have an impact on pancreatic enzyme secretion and pain in chronic pancreatitis. The preparation Panzytrate 2500 (2 x 3 capsules/day containing 1250 units of proteases per capsule) was administered for a 4-week period. In 18 patients with chronic pancreatitis (7 with the severe and 11 with the medium severe and mild form of pancreatitis) the faecal and serum pancreatic elastase was assessed one day before and one day after enzyme substitution...

[Effect of high-dose chemotherapy in patients with relapsing or resistant Hodgkin's disease].

Z Král, J Mayer, M Navrátil, I Vásová, Z Korístek, M Tomíska, J Vorlícek, J Adler, J Vinklárková, K Petráková, P Vodvárka

Vnitr Lek 2000, 46(5):268-271

The authors evaluated a group of 48 patients with relapsing or resistant Hodgkin's disease. The patients were treated by life-saving chemotherapy followed by large doses of chemotherapy and autologous transplantation of haematopoietic cells. For life-saving chemotherapy they used most frequently a combination of VIM in 40 patients and combinations of DHAP, MINE, MiniDexaBEAM. In 11 patients they changed the regime of life-saving chemotherapy because of a poor response. After completed life-saving chemotherapy 18 (37.5%) patients were in CR, 27 (56.2%) in PR and in 3 (6.3%) the disease progressed. For large dose chemotherapy the authors used BEAM in...

[Leptin levels in peripheral blood and bone marrow in orthopedic patients].

A Gaja, Z Churý, L Pecen, N Hejlová

Vnitr Lek 2000, 46(5):272-275

Leptin is a protein with hormonal activity and is produced mainly by adipocytes. Its primary function in the human organism is regulation of the calorie intake via the anorectic action in the hypothalamus. Leptin participates also in the regulation of haematopoiesis and immunity processes. There are many data on leptin production by peripheral adipose tissue and it is also known that leptin is produced by adipocytes of bone marrow. It was assumed for a long time that adipocytes of bone marrow are not only a passive source of energy but have, similarly as stromal cells, a regulatory function. However, it is not clear in what way the adipose tissue of...

[Levels of selenium and glutathione peroxidase in dialyzed patients].

M Hertlová, M Dastych, S Surel, M Senkyrík

Vnitr Lek 2000, 46(5):276-281

The authors examined in 37 patients dialyzed in a dialysis centre in Brno-Bohunice, a region with selenium deficiency in the population the serum selenium and glutathione peroxidase level before and after 4-hour standard haemodialysis across a polysulphone membrane. In 78% patients selenium deficiency was found. The mean value in the whole group was 33.4 micrograms Se/l. The reference range for the Brno population is 41.3-80.7 micrograms/l. After dialysis a rise of the serum selenium level by 15.4 micrograms/l occurred due to haemoconcentration during ultrafiltration and also due to redistribution of fluids and selenium during dialysis. In anuric patients...

[Treatment of hemorrhoids from the viewpoint of the gastroenterologist. Personal experience with the Ginkor Fort preparation].

A Hep, O Robek, T Skricka

Vnitr Lek 2000, 46(5):282-285

Pathological changes in hemorhoid plexes are frequently occurring mainly in elderly. In development of this disease are mainly involved changes in the vessel wall, pressure changes in basin, disturbances in passage of stool and also infectious disease. Instead of the correction of the life-style in therapy are used locally-acting drugs whose basis are local anesthetics, spasmolytics, antiflogistics, antipruriginostics and corticoids in many combinations. The main aim of the orally administered drugs is influence of the vessel-wall tone, decrease of the capillary permeability, circulation betterment, decrease of the oedema and blockage of the inflammatory...

[Monoclonal gammapathy of undetermined significance (benign monoclonal gammapathy)].

Z Adam, M Tomíska, R Hájek, J Vorlícek

Vnitr Lek 2000, 46(5):286-296

Monoclonal gammapathy is a condition that may be related to the malignant lymphoproliferative disease, but more often to a benign lymphoproliferation. Formerly termed benign monoclonal gammapathy it is now called monoclonal gammapathy of unknown significance (MGUS), because years later malignant lymphoproliferative disease may develop. Even benign gammapathy may cause frequent symptoms in a patient. The text describes clinical manifestations of monoclonal protein including various differential diagnostic possibilities.

[Treatment of renal hypertension].

A Oksa, V Spustová, R Dzúrik

Vnitr Lek 2000, 46(5):297-300

In recent years in conjunction with medicamentous treatment of renoparenchymatous hypertension in particular two problems were discussed: target blood pressure values and renoprotective effects of antihypertensive drugs. Prospective studies revealed that a blood pressure reading of < 130/80 mm Hg significantly retards the progression of nephropathy whereby patients with proteinuria > 1 g/d benefit from even lower BP readings. In diabetic nephropathy the drugs of choice are inhibitors of angiotensin converting enzyme (ACEI), already in the incipient stage and also in normotensive patients. The importance of ACEI in the treatment of non-diabetic...

[Lymphocytosis with large granular lymphocytes: case report].

Y Brychtová, M Doubek, J Mayer, A Bulíková, M Krahulová

Vnitr Lek 2000, 46(5):301-304

Lymphoproliferative disorders of large granular lymphocytes (LGL) can arise from either CD3+ T cells or CD3- natural killer cells. Polyclonal proliferation of LG lymphocytes is called LGL lymphocytosis, monoclonal proliferation of LG lymphocytes is LGL leukaemia. Prominent clinical manifestations of LGL lymphocytosis and leukaemia are bacterial infections, splenomegaly, and may be connected with rheumatic or autoimmune disorders. Hematologic findings reveal particularly lymphocytosis, and severe neutropenia. The beta chain gene of T cell receptor rearrangement analysis is necessary for distinguishing of T LGL lymphocytosis from T LGL leukaemia. The...

[Development and perspectives of internal medicine in Slovakia].

I Balazovjech

Vnitr Lek 2000, 46(5):305-308