Vnitřní lékařství, 2000 (vol. 46), issue 10
[Treatment of erosive gastropathy caused by nonsteroidal anti-inflammatory agents using low doses of antacids].
I Rybár, J Rovenský, M Orlovská
Vnitr Lek 2000, 46(10):673-676
In an open clinical, endoscopy controlled study involving 31 patients with erosive NSAIDs-induced gastropathy without Helicobacter pylori infection, the effect of low dose of antacids (120 mmol/l) with aluminium oxide and magnesium oxide (Maalox) administered for 4 weeks was followed. The administration of NSAIDs was not interrupted during the time of treatment. Healing rate of the gastric erosions after four weeks reached 65% (20/31) and endoscopic score in the gastric mucosa proved significant improvement (0.97 +/- 0.49 compared to 0.07 +/- 0.25, p < 0.01). Our results suggest efficacy of low dose antacids containing aluminium in the treatment...
[Monitoring phagocyte activity and free radicals in Helicobacter pylori infections].
B Jurasková, Z Zadák, D Solichová, P Kohout, J Vávrová
Vnitr Lek 2000, 46(10):677-680
The presence of infection in organism induces a lot of Immunological reactions accompanied by creating free Radicals and reactive oxygen species (ROS). These play an important role in elimination of bacteria but also in tissue injury in surrounding. The aim of presented study was to focus on monitoring of ROS and phagocyte activation in subjects infected by Helicobacter pylori (HP) and thus to contribute to our knowledge of the etiopathogenic role of HP in inflammatory gastrointestinal diseases. The results report some differences, which interpretation opens a lot of questions showing how important of role ROS in HP infection may play.
[Cross-sectional study of choice of drug therapy in the acute phase of treatment in acute myocardial infarct--part 1].
J Vlcek, J Gregor, K Macek, J Vítovec, L Práznovcová, J Zajíc, M Starec, J Drázka, F Kulic, R Polásek, R Jirmar
Vnitr Lek 2000, 46(10):681-688
INTRODUCTION: Treatment of acute myocardial infarction is undergoing changes. In the treatment of acute myocardial infarction in particular the following proved useful: thrombolysis, administration of anti-aggregating drugs, beta-blockers and inhibitors of angiotensin converting enzyme. An decisive part is played by the interval between the onset of symptoms and the beginning of hospital treatment.OBJECTIVE: To describe treatment of patients hospitalized at intensive care units for acute myocardial infarctions. Investigate differences between faculty and other hospitals.METHOD: The authors investigated by means of questionaires in a prospective...
[Effect of alendronate therapy on bone turnover--results of a multicenter study].
J Payer, Z Killinger, P Masaryk, S Tomková, Z Kmecová, J Ondrejková, L Necas, J Smoterová, P Ondrejka, H Kratochvilová
Vnitr Lek 2000, 46(10):689-692
Sodium alendronate is a bisphosphonate of the IInd generation with a strong antiresorptive effect. Its favourable effect on reduction of the incidence of vertebral and non-vertebral fractures was repeatedly confirmed. The objective of the multicentre study was to evaluate the effect of administration of 10 mg of sodium alendronate combined with 1000 mg of elemental calcium administered in the course of three months on the N-terminal telopeptide(NTx) a sensitive marker of bone resorption. The group comprised 275 postmenopausal women with densitometrically confirmed osteoporosis. After three months treatment a 53% decline of NTx values occurred as compared...
[Serum copper levels in patients with acute and chronic types of ischemic heart disease and its relation to lipoprotein levels and extent of coronary atherosclerosis].
F Málek, I Karel, R Polásek, R Spacek, L Lisa, J Dvorák, P Stanka
Vnitr Lek 2000, 46(10):693-696
The authors assessed serum copper and lipoprotein concentrations in a group of 67 patients hospitalized successively at the cardiological department. During hospitalization they were subjected to selective coronarography with assessment of the angiographic score. In 35 patients the angiographic examination was made during the chronic stage of IHD (group A), in 32 patients it was indicated on account of acute coronary syndrome (group B). The authors found that serum copper concentrations are significantly higher in patients with acute forms of IHD (group B, p < 0.001). Serum copper concentrations do not correlate significantly with lipoprotein concentrations...
[Monitoring minimal residual disease in patients with hairy cell leukemia in complete remission after treatment with 2-chlorodioxyadenosine].
P Zák, L Chrobák, K Dědic, K Podzimek
Vnitr Lek 2000, 46(10):697-703
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA) induces in 85% patients complete remission. Complete remission is defined as the condition when signs of activity of the disease are absent, splenomegaly and lymphadenopathy are absent, the hemoglobin concentration is > or = 120 g/l, the absolute number of granulocytes is > or = 1.5 x 10(9)/l and the number of thrombocytes is > or = 100 x 10(9)/l. In complete remission in the peripheral blood, bone marrow aspirate and bioptic samples obtained by trephin bone marrow core biopsy, using standard staining (hematoxylin-eosin and May-Grünwald-Giemsa's method), no leukemic cells...
[Endoscopic sonography in the diagnosis of chronic pancreatitis in the early stage].
I Novotný
Vnitr Lek 2000, 46(10):704-708
The author summarizes in the submitted review diagnostic possibilities of early stages of chronic pancreatitis. He evaluates from that aspect possibilities of common imaging methods (ultrasonography, computer tomography, endoscopic retrograde cholangiopancreatography) and endoscopic ultrasonography (EUS). Evaluation of the secretory exocrine capacity by means of the secretin-cerulein test. Although the method is demanding from the aspect of routine diagnosis, it is a method with comparable sensitivity and perhaps even greater specificity than ERCP. Other tests of exocrine pancreatic secretion are not sufficiently sensitive to be used for this diagnosis....
[A study of the United Kingdom Prospective Diabetes Study and its results].
Y Pospísilová
Vnitr Lek 2000, 46(10):709-714
This article summarizes the results of the United Kingdom Prospective Diabetes Study, which monitored more than 4,000 patients with diabetes mellitus type 2 for an average period of 11 years after the establishment of the diagnosis. The results of this study are as follows: A lower number of microvascular, but not macrovascular complications was established in the intensively treated patients (fasting plasma glucose less than 6 mmol/l) than was the case in the conventionally treated patients (fasting plasma glucose concentration less than 15 mmol/l). No differences in efficacy in reducing glycaemia were found in the intensive treatment between sulphonylurea,...
[Thrombotic complications in patients with malignant diseases].
D Karetová
Vnitr Lek 2000, 46(10):715-718
The incidence of thromboembolic disease (TED) in malignant diseases is high and is often the cause of death in these patients. The most important thrombogenic factors are changes of the coagulation system, venostasis, changes in the function and structure of the endothelium and the influence of specific anti-tumour therapy. The most frequent clinical manifestation is phlebothrombosis of the lower extremity. Diagnostic procedures in detection of thrombosis do not differ fundamentally from standard procedures (clinical examination, duplex sonography, phlebography, possibly pulmonary scintigraphy). More intensive prophylaxis of TED is necessary under...
[Endothelins--physiology, pathophysiology and importance in arterial hypertension].
I Lazúrová, H J Kramer
Vnitr Lek 2000, 46(10):719-723
Endothelins are peptide tissue hormones with a powerful vasoconstrictor effect. The most important one among them, endothelin-1, is the most powerful vasoconstrictor substance in the human organism which causes constriction of the blood vessels, in particular renal, coronary, pulmonary and cerebral arteries, bronchioles, and inhibits the secretion of atrial natriuretic factor and vasopressin. Because of these effects importance in the pathogenesis of some diseases is ascribed to it, e.g. myocardial infarction, cardiac failure, asthma bronchiale, Raynaud a syndrome, renovascular disease, cyclosporin-induced nephrotoxicity and cerebrovascular attacks....
[Acute pancreatitis as the road to diagnosis of primary hyperparathyroidism].
L Husová, M Senkyrík, J Lata, V Hrbková, P Husa, J Dolina, M Podrábská, P Ourednícek
Vnitr Lek 2000, 46(10):724-727
The authors present the case of a 78-year-old female patient who was admitted on account of acute pancreatitis complicated by acute myocardial infarction. The authors detected in the patient a serum repeatedly high calcium levels and high levels of intact parathormone. Scintigraphic examination revealed marked foci in the middle of the neck at the level of the inferior pole of the thyroid gland. These examinations confirmed the diagnosis of primary hyperparathyroidism. In view of the patient a serious condition, conservative treatment of hypercalcaemia and acute pancreatitis and myocardial infarction was started. The patient was released into domiciliary...
[Early renal failure caused by mesalazine].
D Musil
Vnitr Lek 2000, 46(10):728-731
The author describes a case of early onset of asymptomatic renal insufficiency in a young patient with ulcerative colitis, treated by large doses of mesalazine. After discontinuation of the drug rapid restoration of renal functions occurred. Contrary to all hitherto published cases, this patient developed renal failure very soon. Urea serum levels reached pathological values after 27 days and the creatinine level already 15 days after the onset of mesalazine administration. The renal affection was unequivocally confirmed by examination of the urine (semiquantitative and quantitative) and dynamic functional scintigraphy.
[Who was Mr. McBean and what resulted from his death?].
M Doubek, O Kalous, A Oborilová
Vnitr Lek 2000, 46(10):732-735
Authors present a historical overview of multiple myeloma. The first well-known case of multiple myeloma was that of Mr. McBean described in 1846, 1847, and 1850 by John Darlympe, Henry Bence Jones, and William MacIntyre. The term multiple myeloma dates from 1873, and was introduced by von Rusitzky. In 1889, Otto Kahler published the case report about Dr. Loos, his patient with multiple myeloma. In 1895, Marschalkó described the essential characteristics of plasma cells. Authors present other interesting early cases of multiple myeloma and diagnostic advances in this disease.