[Treatment of significant coronary stenoses using stents without preliminary balloon angioplasty: present status, results, perspectives].

J Veselka, D Tesar, M Mates, M Aschermann, T Urbanová, P Telekes, I Zvánovcová, T Honěk, S Tůma

Vnitr Lek 1998, 44(12):693-697

The authors present an account on a group of 57 patients where they tried to treat 58 significant coronary stenoses by means of direct stenting without predilatation. In two patients they were able to implant the stent only after previous dilatation, in one instance postdilatation was necessary because of a residual stenosis of more than 20% and in one instance it was necessary to implant another stent on account of distal dissection. Direct stenting was successful in 93%. At the significance level of p < 0.05 significantly shorter fluoroscopic and total intervention times were achieved as compared with the control group where the standard procedures...

[Autologous transplantation of peripheral stem cells in treatment of recurrent multiple myeloma].

M Krejcí, Z Adam, J Mayer, R Hájek, J Vorlícek

Vnitr Lek 1998, 44(12):698-701

Treatment of relapses of multiple myeloma is a problem which was not resolved quite satisfactorily so far. One of the possible therapeutic approaches is administration of major doses of chemotherapeutic agents with the support of autologous transplantation. As compared with standard treatment, according to some authors thus more remissions are achieved and a longer overall survival. The submitted paper provides information on the therapeutic results in relapses of multiple myeloma by administration of large doses of melfalan (200 mg/m2) with support of autologous transplantation in seven patients in the authors department. In these patients for stimulation...

[Significance of free radicals in the pathogenesis of rheumatic diseases and possibilities of decreasing their pathogenic effects].

M Kucera, J Racek, V Holecek, L Trefil

Vnitr Lek 1998, 44(12):702-706

The authors present the result of their work where they provide evidence that in inflammatory and degenerative diseases the break-down on superoxide in inadequate. This oxygen radicals and its metabolites play a significant role in the pathogenesis of these diseases. The authors revealed a severe defect in superoxide degeneration in particular in articular exudates of patients with active synovitis. Administration of the preparation Selzink-Plus of PRO.MED.CS Co. Prague which contains selenium, zinc, beta-cyrotene, vitamin C and E along with antirheumatic treatment improves according to the authors the breakdown of superoxide and its metabolites and...

[Benefit of direct determination of LDL-cholesterol (comparison with LDL measurement using calculated estimates].

D Stejskal, R Pastorková, M Franková, J Bartek, D Horalík

Vnitr Lek 1998, 44(12):707-713

Treatment of dyslipidemia and its frequently associated complications (manifest atherosclerosis) is very pretentious from the economic aspect. Diagnostic and therapeutic criteria are based mainly on biochemical analyses. Although demands on laboratories are relatively strict (respecting defined laboratory errors, analytical and preanalytical conditions), when defined diagnostic criteria are used, the results of biochemical analyses are not yet satisfactory. A typical example is the stratification of risk patients according to the LDL concentration which in our country is very often preferred, although the LDL concentration is based only on calculation...

[Caplan's syndrome].

E Benesová, P Brhel

Vnitr Lek 1998, 44(12):714-717

The authors describe two cases suffering from Caplan s syndrome, i.e. a combination of pneumoconiosis and rheumatoid arthritis, in miners of deep coal mines in southern Moravia. The finding on the lungs preceded the manifestation of articular symptoms. The disease progressed even after the risk of fibrogenic dust was eliminated. In both patients occupational diseases were involved.

[A multicomparmental and multifactorial model of production of plasminogen activator inhibitor (PAI-1). I. Experimental studies].

P Galajda, P Kubisz, M Mokán

Vnitr Lek 1998, 44(12):718-721

Hypofibrinolysis caused by increased PAI-1 levels in patients with insulin resistance (IR) is one of the most common acquired prothrombotic states with higher risk of arterial thrombosis associated with atherosclerosis. Increased PAI-1 levels are caused by PAI-1 hyperproduction in various compartments owing to various factors (multicompartmental and multifactorial model). Metabolic compartment, including visceral adipocytes and hepatocytes, is sensitive on stimulative action of insulin, proinsulin and some cytokines. This pool is responsible for elevated PAI-1 levels in obesity. Vascular compartment, including mainly endothelium, is sensitive on thrombin,...

[Pathophysiologic mechanisms of atrial rhythm disorders. II. Atrial flutter].

B Stancák

Vnitr Lek 1998, 44(12):722-726

Atrial flutter is a common cardiac dysrhythmia which responds for half of the supraventricular tachycardias with exception of atrial fibrillation. Activation and entrainment mapping studies in man and in animals confirmed the reentry mechanism of atrial flutter and demonstrated that the reentry circuit is located in the right atrium. The most important anatomical structures which enable the occurrence of atrial flutter are crista terminalis, Eustachian valve/ridge and tricuspid annulus. In typical atrial flutter the impulse rotates "counterclockwise". According to the present knowledge the reentry circuit surrounds a central obstacle made by the orifices...

[Standards of care in diabetic nephropathy. Recommendations of the Czech Diabetology Society and the Czech Nephrology Society].

V Bartos, V Teplan, P Boucek

Vnitr Lek 1998, 44(12):727-731