Vnitřní lékařství, 1998 (vol. 44), issue 10

[Serum noradrenaline and ventricular tachycardia].

J Pella, D Stopek, E Rybárová, L Fedáková, B Stancák, J Bodnár

Vnitr Lek 1998, 44(10):573-576

Sudden cardiac death is in the majority of cases due to ventricular tachycardia (VT) developing into ventricular flutter or ventricular fibrillation. It is therefore very important to detect patients with the risk of sudden cardiac death because their mortality depends on the treatment selected. The authors tried to shift the problem of sudden cardiac death into the sphere of cardioendocrinology. They examined the serum levels of norepinephrine (NE) in 17 patients. They collected simultaneously blood samples from the left cubital vein and right atrium after 5 minutes stimulation of the apex of the right ventricle, the frequency of stimulation being...

[Insulin antibodies in patients with type 2 diabetes mellitus].

E Martinka, J Straková, M Mokán

Vnitr Lek 1998, 44(10):577-581

AIM OF STUDY: To assess the prevalence of insulin antibodies (IA-A) and their binding capacity (c%IA-A) in Type-2 diabetic patients and relation of IA-A/c%IA-A to duration of diabetes, type of therapy, kind/dosage of administered insulin, glycaemic control and to appearance of hypoglycaemic episodes.SUBJECTS: 196 hospitalised patients with type-2 diabetes mellitus (negative for antiGAD-Ab). Assessed parameters: age, duration of diabetes mellitus, duration of insulin-therapy, BMI, glycaemic profile, IRI, C-peptide, IA-A and antiGAD-Ab (Cis bio international, distr. fy Solupharm).RESULTS: Prevalence of IA-A and their c%IA-A were related to treatment...

[Serum leptin, early atherosclerosis and hypolipidemia (a new, previously undescribed effect of pravastatin, a hypolipemic agent)].

D Stejskal, V Růzicka, J Bartek

Vnitr Lek 1998, 44(10):582-587

Hyperleptinemia is considered to be one of predictors of early atherosklerosis complications. This stimulated us to investigate differences between leptinemia in persons with accelerated atherosclerosis and leptinemia in probands without atherosclerosis complications. The study also verified whether leptinemia and its relationship to other anthropometric and biochemical parameters can differ in hypolipemic-treated probands and hypolipemic-untreated individuals. We examined 89 probands with accelerated atherosclerosis. The controls were 20 persons without any signs of accelerated atherosclerosis. Probands with accelerated atherosclerosis had a slight...

[Leptinemia in persons with acute myocardial infarct].

D Stejskal, V Růzicka, J Bartek, D Horalík

Vnitr Lek 1998, 44(10):588-592

The purpose of the study was to verify whether the currently reported relationship between leptinemia and adipose tissue mass can be applied to cases of acute coronary attack. An increased number of cytokines has been reported in severe acute myocardial infarctions so that correlation between cytokines and leptin was investigated. Correlation between standard coronary markers and leptinemia was also studied. We examined 48 probands, patients of the Coronary Unit, Hospital, Sternberk, who were hospitalized for acute myocardial infarction (AMI--16 probands) or for unstable angina pectoris (UAP--22 probands). The persons with AMI had leptinemia and a...

[Serum leptin in women during the third trimester of pregnancy].

D Stejskal, V Růzicka, J Novák, L Jedelský, J Bartek, D Horalík

Vnitr Lek 1998, 44(10):593-597

Leptin is a small protein produced mainly by adipocytes. Recently, its relationship to obesity has been studied extensively. It was proved that obese individuals have either relative or absolute leptin deficiency. Several years ago, leptin was found to be produced also by the placenta. This stimulated us to study relationship between leptinemia and placental hormones in 85 women in the second gravidity trimester. Within the prenatal screening, these pregnant women were subjected to analysis of AFP, hCG, SP-1 glycoprotein and leptin and the results obtained were processed statistically. The control group consisted of 20 nonpregnant women with tetany....

[Reversible dysfunction of myocardial contraction].

M Mates, J Veselka

Vnitr Lek 1998, 44(10):598-605

It has been known for more than 20 years that in some patients after revascularization partial or complete improvement of previous left ventricular dysfunction occurs. The condition for this improvement is viable myocardium, i.e. contractile reserve. Chronic reversible contractile dysfunction, also called hibernating myocardium heart muscle is along with the presence of acute reversible dysfunction--a stunned myocardium the prerequisite for this improvement. In the submitted review the authors try to present at least some contemporary views on the pathophysiological mechanism of the development of a hibernated myocardium. The normal blood flow through...

[Angiology as a most important specialty and an integral part of internal medicine].

P Gavorník

Vnitr Lek 1998, 44(10):606-608

The author wishes to remind the broad medical public, in particular specialists in internal medicine, that vascular diseases are the most widespread, most serious and most urgent medical, social and economic problems of all countries in the present world. They cause a high morbidity, associated with work incapacity, disability and about half of all deaths in the population, i.e. twice as many as the second most frequent cause of death--oncological diseases (angioepidemy). Vascular diseases and their risk factors are internal diseases which usually effect several organs and tissues of the human organism. The author refutes disintegration of internal...

[Presence of CD markers on hematopoietic cells].

K Koubek

Vnitr Lek 1998, 44(10):609-623

The author summarizes the expression of membrane markers of haematopoietic cells. The proliferation and differentiation of cells in individual lineages as well as immunophenotype mozaik of membrane molecules included into CD nomenclature is evaluated.