[Rheumatology and rheumatologists today].

K Trnavský

Vnitr Lek 1997, 43(2):63-65

[Pharmacotherapy in patients after myocardial revascularization surgery 1991-1995].

L Bartůněk, V Bartůnková, P Schamburek

Vnitr Lek 1997, 43(2):66-69

The authors discuss in a retrospective study pharmacotherapy administered to 302 patients after revascularization surgery of the heart muscle in 1991-1995 in Konstantinovy Láznĕ. In the introduction they evaluated the ratio of drugs used in secondary prevention of infarctions incl. trends of their use in individual years between 1991-1995 (antiaggregation treatment-beta-blocking agents, calcium channel blockers, ACE inhibitors, hypolipidaemic agent, rapidly acting and retardes forms of nitrates). They evaluate specially medication with beta-blocking agents from the aspect of cardioselectivity, internal sympathomimetic activity, membrane stabilizing...

[Estimation of the mean right atrial pressure using echocardiography].

J Veselka, V Mrázek, P Bartůněk

Vnitr Lek 1997, 43(2):70-73

The authors measured in a group of 30 patients invasively the pressure in the right atrium and at the same time or within 60 minutes the diameter of the interior vena cava and its changes in conjunction with respiration. They revealed a statistically significant relationship between all parameters of the diameter of the interior vena cava assessed by echocardiography and the mean right atrial pressure. The closest correlation was found in the index of the inspiration diameter of the inferior vena cava (p = 0.01; r = 0.824). A critical value of the index of the inspiration diameter of the inferior vena cava greater than or equal to 10 mm revealed patients...

[The role of calcium inhibitors in the treatment of arterial hypertension].

J Hrnciar, M Hrnciarová, K Jakubíková

Vnitr Lek 1997, 43(2):74-80

Base on their own experience with isradipine and results of a multicentric study with amplodipine in the Slovak Republic, as well as based on data in the literature the authors conclude that: 1. In the treatment of arterial hypertension associated in the syndrome of insulin resistance (syndrome X and 5H resp.) with type 2 diabetes, hyperlipiproteinaemia and hyperinsulinism drugs of first choice include ACE-inhibitors and Ca antagonist of the second generation, dihydropiridine type, such as amplodipine, isradipine, fellodipine, nirtendipine etc. ACE inhibitors and Ca antagonist of the dihydropyridine type with prolonged effect have a good tolerance,...

[Fibrinogen and diabetic microangiopathy].

V Mojto

Vnitr Lek 1997, 43(2):81-86

Diabetic microangiopathy is in its developed form a serious complication for patients with diabetes, in particular diabetes type 1. An important aspect of prevention of organ damage is early assessment of factors which accelerate the development of microangiopathy. In the submitted paper the authors draw attention assessment of plasma fibrinogen, thrombocyte aggregation in relation to renal functions in type 1 diabetics as well as other indicators which promote the development and acceleration of diabetic nephropathy. In patients with diabetic nephropathy a correlation was found between fibrinogen and thrombocyte aggregation as well as between the...

[Occurrence of copper metabolism abnormalities in the families of four individuals with newly diagnosed Wilson's disease].

M Dastych

Vnitr Lek 1997, 43(2):87-90

The author describes the incidence of abnormalities of copper metabolism in families of four patients with recently diagnosed Wilson's disease. The patients were three men ad one girl, age 17-22 years where Wilson's disease was diagnosed on the basis of liver symptomatology and a typical laboratory finding. The period which elapsed between detection of the first clinical and laboratory symptoms and the establishment of the diagnosis of Wilson's disease varied between 1 months to eight years. Clinical and laboratory examination of all relatives of the affected subjects (parents and siblings) revealed an increased incidence of biochemical abnormalities...

[Relation between types of erythrocyte membrane defects and the clinical picture in hereditary spherocytosis].

V Brabec, J Palek, K Petrtýlová, J Cermák, P Jarolím

Vnitr Lek 1997, 43(2):91-94

From total number of 130 patients with hereditary spherocytosis from 75 families in 119 patients from 69 families a defect of membrane proteins was detected. In 23 families (33.3%) a spectrin defect was involved, in 32 families (46.3%) a combined defect of spectrin and ancyrine and in 14 families (20.3%) a defect of band 3 proteins. Investigation of the membrane defect and the clinical and laboratory picture revealed that the band 3 protein defect of spectrin and ancyrine. There are significant differences in the clinical picture of the two latter defects.

[Immunoscintigraphy examination of bone marrow in patients with hematologic diseases].

M Maturová, V Bláha, J Kolínská

Vnitr Lek 1997, 43(2):95-97

In 36 patients with different haematological diseases the authors examined by immunoscintigraphy the bone marrow using the 99mTc preparation Scintimun Granulozyt of Behring Co. They studied the distribution of haematopoietic tissue order to detect deviations from normal, focal defects, elongation of haematopoiesis into the periphery of long bones or extramedullary haematopoiesis. Distribution of haematopoietic tissue was evaluated visually and semiquantitatively.

[Use of PTCA in a gastroepiploic aortocoronary graft].

J Kovác, F D Murgatroyd, P K Verma, D P de Bono

Vnitr Lek 1997, 43(2):98-101

The use of the gastroepiploic inferior artery as an aortocoronary graft is at present a method of third choice after the mammary artery and venous grafts in revascularizations of the heart muscle. The results are comparable with those obtained with the mammary artery. With regard to the increasing number of operations are more plentiful on the development of atherosclerosis of the above mentioned graft. This dumps the initial enthusiasm that in this artery atherosclerosis does not develop. Reports on PTCA, when this artery is affected, are so far rate. The authors performed a successful PTCA of this graft in a patient with complete affection of the...

[Successful gamma globulin therapy in a patient with anti-IgA antibodies].

J Litzman, P Broz, V Král, J Lokaj

Vnitr Lek 1997, 43(2):102-104

A case report of a patient suffering from common variable immunodeficiency with anti-IgA antibodies is described. These antibodies were probably the cause of repeated anaphylactic reactions during substitution gammaglobulin treatment, and lead to discontinuation the therapy lasting 4 years. The reintroduction the therapy was enabled by the therapy with low-IgA contents intravenous immunoglobulin (Endobulin, Immuno Vienna).

[Acute and chronic heart failure].

M Stejfa, J Toman, L Spinarová

Vnitr Lek 1997, 43(2):105-110

Cardiac failure is a syndrome which comprises ventricular dysfunction (confirmed by echocardiography) and compensating mechanisms (immediate activation of the sympathetic nerve and functioning of Starling's mechanism, within hours or days activation of RAAS within days or weeks hypertrophy of the heart). Cardiac failure develops rapidly either in a previously healthy subject (first extensive IM, diffuse myocarditis, acute aortic or mitral regurgitation) or in a damaged heart (IHD, KMP, defect) as a result of sudden excessive burdening (ischaemia, arrythmia, infection, surgery etc.) or spontaneously (end-stage). It is manifested above all by "backward"...

[Infection with Helicobacter pylori and its serologic detection].

J Havlasová, J Krejsek, J Bures

Vnitr Lek 1997, 43(2):111-114

Pathogenicity of Helicobacter pylori is based partially on the production of toxic substances. On the other hand the gastric mucosal injury may be caused by the Helicobacter pylori-induced host inflammatory response. Considerable antibody response during Helicobacter pylori infection provides a ground for indirect non-invasive serological detection. Appropriate clinical applications of serological tests are based on a good understanding of the antibody response characteristics during Helicobacter pylori infection.

[Antigens in the serologic detection of Helicobacter pylori infection].

J Havlasová, J Krejsek, J Bures

Vnitr Lek 1997, 43(2):115-119

The paper deals with the types of antigens for detection of anti-Helicobacter pylori antibodies. There are informations about the protein composition of Helicobacter pylori and about the specificity and immunogenicity of particular proteins. The authors review and evaluate different types of antigenic preparations used in serological tests and inform about the commercial kits for serological detection of Helicobacter pylori infection.

[Leptin and its biological and clinical significance. Is leptin and insulin resistance in the X-5H hormonal metabolic syndrome a parallel or causally-linked phenomenon?].

J Hrnciar

Vnitr Lek 1997, 43(2):120-124

Leptin 167 an amino acid product of the recently discovered obesity gene "ob-gene", is a tissue hormone of adipose tissue. It is a hormonal satiety signal or a signal for terminating food intake. Its level rise after a meal or after administration. Rats with a mutation of the ob-gene have zero or very low leptin levels, are hyperphagic, obese and sterile, develop diabetes as a result of overeating. Administration of recombinant leptin arrests hyperphagia, the body weight declines and sexual function improve partly, in particular in males. It seems that leptin controls not only the function of the hypothalamic satiety centre but also the output of GnRh...