[Extra-thyroid autoantibodies in autoimmune thyroiditis].

I Sterzl, V Vavrejnová, P Matucha

Vnitr Lek 1996, 42(11):733-737

Organ specific autoimmune diseases do not occur isolated. In the authors group of 4509 patients with confirmed autoimmune thyroiditis the authors investigated the frequency of extrathyroid organ specific and non-specific autoantibodies. The objective was to draw attention to other autoimmune diseases which may not yet be clinically manifest. The mutual positivity of antibodies against thyroid peroxidase (TPO) and antibodies against the adrenals was: in the zona glomerulosa 21.1%, in the zona fasciculata 3.0%, in the zona reticularis 19.5%, in the adrenal medulla 9.0%. The mutual positivity of antibodies against TPO and ovaries was 28.5%, testes 12.5%,...

[Status and selenium intake as related to the thyroid gland in the population of Znojmo].

J Kvícala

Vnitr Lek 1996, 42(11):738-742

In a group of 360 people aged 6-65 years of both sexes from the Znojmo area the author investigated the selenium status and intake by serum analyses (246 cases), urine analyses (356 cases) and hair analyses (28 analyses in middle-aged men). By correlation analysis the author investigated the relationship of selenium and metabolic and peripheral thyroid parameters. From the low selenium concentration in all investigated materials (42 micrograms Se/l serum, 8.2 micrograms Se/urine, 7.2 micrograms Se/g creatinine in urine and 0.23 microgram Se/g hair) the author concludes that there is selenium deficiency in the investigated population, the primary cause...

[Changes in urinary calcium and magnesium levels during supplementation with iodine and selenium].

A Simecková, J Cerovská, J Kvícala

Vnitr Lek 1996, 42(11):743-746

The authors examined 31 children aged 10-13 years before and after 5-month administration of 100 micrograms iodine (as iodide 100 Merck) and 57 university students (age 18-23 years) divided into four groups. The control group of 15 students received placebo daily, 20 students took selenium (50 micrograms selenium Merck), 8 students iodine (100 micrograms iodide) and 14 students a combination of equal amounts of both elements. The authors investigated the calciuria, mangesiuria and calcium/creatinine ratio and magnesium/creatinine ratio. They found a significant drop of magnesiuria in school children after iodine intake, and in university students there...

[Plasma and tissue levels of cytokines and adhesive molecules in patients before strumectomy].

Z Masek, J Astl, J Dusková, R Bílek, Z Novák, P Vaník, K Vlasicová, J Betka, P Schneiderka

Vnitr Lek 1996, 42(11):747-750

From a group of 134 patients with complete documentation before goitrectomy the authors selected 10 histologically defined cases of (A) simple colloid nodular goitre, (B) toxic parenchymatous goitre type GB and (C) autoimmune thyroiditis. Marked hormonal suppression was achieved in group B by thyrostatic therapy, as compared with A and C, the autoantibody titres (TGAb and TMAb) differentiated the groups. The authors examined the interleukin 6 concentrations and those of its soluble receptor (IL-6, IL-6R), of the tumour necrotizing factor alpha (TNF-alpha) interferon gamma (IFN-gamma) and of adhesion molecules ICAM-1 and VCAM-1. Plasma values were,...

[Ret proto-oncogene mutation found in the Czech population and its predictive value for offspring of patients with medullary carcinoma of the thyroid gland].

I Mazura, J Vcelák, B Bendlová, M Neradilová, J Němec, P Stolba

Vnitr Lek 1996, 42(11):751-756

The authors completed a total of 23 pedigrees with the clinical diagnosis of medullary thyroid carcinoma (5 MEN 2A pedigrees, 11 FMTC pedigrees and 7 MTC pedigrees). Using the method of polymerase chain reaction (PCR), it was possible to define the rate of the most frequent mutations in exons 10, 11 and 16 of Ret-protooncogene present in the Czech population. The most frequent hereditary mutation found in MEN 2A and FMTC groups is substitution of thymine for cytosine in position 2095 of the transmembranous domain of the Ret-tyrosine kinase gene. Another six types of known mutations were tested.

[Dermatoglyphics--an attempt to predict diabetes].

H Platilová, Z Pôbisová, V Zamrazil, K Vondra, L Dvoráková

Vnitr Lek 1996, 42(11):757-760

Dermatoglyphs do not change throughout life. The authors sought their "predictive type" for diabetes with regard to the possibility of early prediction and thus prevention of the development of diabetes, in particular type 2. They used a point score of the abnormality in three qualitative and two quantitative signs and found, as compared with the normal population, in groups of subjects with impaired glucose tolerance, DM II and DM I deviations with an increasing significance. The frequency of thus assessed abnormalities in each subject on both hands (0-10) was compared in relations to the diagnosis and family-history of diabetes and the authors evaluated...

[Non-insulin-dependent diabetes mellitus--strategies and problems in genetic research].

B Bendlová, I Mazura, J Vcelák, J Perusicová

Vnitr Lek 1996, 42(11):761-766

Non-insulin dependent diabetes mellitus (NIDDM) is at present one of the most serious and widespread diseases with a mass incidence and its treatment is very costly. In the genesis and development of the disease genetic factors participate along with environmental factors. Genetic research of NIDDM is difficult, as ensues from the very essence of this heterogeneous disease. Research concentrates on the identification of specific genetic determinants which influence the predisposition of the individual to glucose intolerance which, if revealed, would make more effective prevention and treatment possible. Intensive research is focused on different candidate...

[Thyroglobulin and microsome autoantibodies and their clinical significance in adult type I diabetics].

K Vondra, J Vrbíková, E Ivaskovál, Z Pobisová, I Porsová-Dutoit, J Skibová, P Stolba, M Voborská, I Sterzl

Vnitr Lek 1996, 42(11):767-771

In 34 patients with type 1 diabetes manifested in postadolescent age (mean age at time of diagnosis 25 years, 18 women and 16 men) after the establishment of the diagnosis perspectively the presence of antibodies against thyroglobulin and the microsomal fraction and their relation to affection of the thyroid gland was investigated. During an investigation of 20% of the patients the authors provided repeatedly evidence of the presence of both antibodies, in 23% repeatedly only against microsomes. In 21% some antibodies were detected only once. In the course of the investigation in 65% of the patients thyroid antibodies were found. The clinically most...

[The effect of metformin on lactate levels in type II diabetes].

J Perusicová, V Cacáková, A Richtrová

Vnitr Lek 1996, 42(11):772-775

The authors investigated the lactic acid levels in the blood of 57 type 2 diabetics treated with metformin. The mean lactate level before onset of metformin treatment was in the whole group 2.01 +/- 0.36 mmol/l and after 6 months of metformin administration it remained unchanged 2.00 +/- 0.42 mmol/l. Compensation of diabetes evaluated by HbAlc improved significantly (9.74 +/- 1.62% before treatment, and 8.52 +/- 1.36% after 6 months of treatment). The mean cholesterol levels declined significantly and the mean triacylglycerol levels were after two months of metformin administration significantly lower. Metformin treatment did not lead to an increase...

[Hemostasis in patients with diabetes mellitus. II. Tissue factor and the extrinsic blood coagulation inhibitor].

P Galajda, E Martinka, P Kubisz, J Ivanková, M Ochodnický, J Polko, M Mokán

Vnitr Lek 1996, 42(11):776-778

In the submitted pilot study we examined 37 patients suffering from diabetes mellitus without vascular complications and 15 healthy blood donors. The diabetic patients had not, as compared with the blood donors, significantly elevated values of the tissue factor (TF) and tissue factor pathway inhibitor (TFPI). The TFPI levels correlated with other markers of endothelial dysfunction, in particular thrombomodulin (r = 0.452, p < 0.01) and with triacylglycerol and cholesterol levels. They did not correlate with age, the C-peptide level and BMI.

[Ablation of supraventricular tachydysrhythmias with direct and radiofrequency current].

B Stancák, J Pella, J Resetár, M Palinský, J Bodnár

Vnitr Lek 1996, 42(11):779-783

Ablation therapy of tachycardias refractory to pharmaceutical preparations is considered in recent years the method of choice. In the submitted paper the authors give an account of 12 years experience with ablation treatment of supraventricular tachycardias. The group comprises 23 patients, who were subjected to ablation therapy by radiofrequency current (RF) on account of relapsing supraventricular dysrhythmias, resistant to medicamentous treatment (between May 1994 and February 1996). The mean age of the patients was 60.4 +/- 9.2 years. The historical control group is formed by 13 patients who were subjected to ablation of the AV junction by direct...

[The role of thromboxane in the pathogenesis of nephropathies].

R Dzúrik, Z Krivosíková, V Spustová

Vnitr Lek 1996, 42(11):784-788

Impaired haemostasis, in particular aggregation in renal disease stimulated research of its prevention and treatment. The achieved results are a significant contribution not only to theoretical research but also to its application in nephrological practice. The submitted review presents specific features of nephrological patients ensuing from overproduction of prostaglandins, in particular thromboxane, by renal cells, focused on glomeruli where mesangial and epithelial cells participate in prostaglandin production and where thromboxane is associated with hyperfiltrations, proliferation, aggregation and other processes damaging glomeruli.

[Spontaneous ascites infections].

J Lata

Vnitr Lek 1996, 42(11):789-791

Spontaneous ascitic infection is a relatively frequent, serious and rarely diagnosed complication of cirrhotic ascitic. The author summarizes the classification of the disease and recommends to use term spontaneous ascitic infection instead of the narrower concept spontaneous bacterial peritonitis. He discusses the symptoms of the condition, its diagnosis and contemporary trends in treatment and prevention. He emphasizes in particular the necessity to consider this complication of cirrhosis, to diagnose it in time and treat it and thus to improve the prognosis of patients with cirrhosis and ascitic.

[Prevention of thromboembolism in patients with atrial fibrillation].

J Veselka, P Bartůněk

Vnitr Lek 1996, 42(11):792-795

Atrial fibrillation is a disorder of the cardiac rhythm associated with an increased risk of thromboembolism. Several studies in the past confirmed that anticoagulation or also antiaggregation therapy is associated in these patients with a reduced incidence of cerebrovascular attacks and peripheral embolism. For a more objective assessment of the risk of individual patients risk factors of thromboembolism in atrial fibrillation were defined. They include cardiac insufficiency, hypertension, a history of embolism, left atrial dilatation, systolic dysfunction of left ventricular hypertrophy and spontaneous echo contrast. This risk stratification of patients...

[Education of diabetics. Recommendations of the Czech Diabetology Society].

Vnitr Lek 1996, 42(11):798-799

[Basic indicators characterizing the acid-base equilibrium in the body and its disorders].

V Rosival

Vnitr Lek 1996, 42(11):801-802

[Dosage of ACE inhibitors in heart failure].

P Jerie

Vnitr Lek 1996, 42(11):802-804