[Selected anthropometric findings in women with disorders of glucose tolerance with hypertension].

Z Pôbisová, V Zamrazil, P Bláha, H Platilová, A Simecková, E Trunecká, V Vavrejnová, R Reisenauer

Vnitr Lek 1990, 36(6):521-525

In a group of 26 women with an impaired glucose tolerance anthropometric measurements of basic somatometric characteristics were made with special attention to the subcutaneous fat distribution and compared the findings with the healthy Czech population. Changes in body build, BMI, subcutaneous body fat distribution were evaluated and the causality of the relationship between blood pressure and gluteofemoral and abdominal obesity was investigated. From the author's observations ensues that in the group of women with impaired glucose tolerance overweight was recorded, as compared with the normal population, disproportions in the circumferences of the...

[The effect of streptozotocin-induced diabetes treated with insulin on the metabolism of calcium, magnesium and phosphorus].

A Simecková, P Stolba, K Hátle, V Zamrazil, M Neradilová

Vnitr Lek 1990, 36(6):526-530

In a group of rats with streptozotocin induced diabetes the excretion of calcium, magnesium, phosphorus and creatinine in urine was investigated and the calcium, magnesium and phosphorus content of bone in relation to the duration of the disease. The authors observed that in diabetic rats the urinary losses of calcium, magnesium and phosphorus increase significantly. The creatinine excretion is also significant but lower in relation to calciuria and therefore the value of Nordin's index in diabetic rats rises markedly. Bone of diabetic rats in the early stage of diabetes (32 days) loses magnesium, while the calcium and phosphorus content does not change...

[Changes in magnesium and ionized calcium serum levels in disorders of glucose tolerance].

V Zamrazil, A Simecková, V Vána, J Bednár, K Vondra

Vnitr Lek 1990, 36(6):531-536

In a group of 58 subjects with a strictly defined glucose tolerance (38 normal--nGT, 10 impaired glucose tolerance--pGT, 10 type II diabetics treated by diet) the authors investigated the mutual relationship between changes in the blood sugar level and insulin serum level in relation changes of calcium, ionized calcium, magnesium and total proteins. In addition to expected differences in the native blood sugar level and insulinaemia, the authors found in pGT group in reduction of ionized calcium and magnesium on fasting. In the course of the oGTT in pGT group there is a rise of ionized calcium and magnesium and thus the changes, as compared with the...

[Anticoagulantion and antiaggregation therapy in patients with unstableangina pectoris].

J Charvát, J Fiserová

Vnitr Lek 1990, 36(6):537-543

Heparin, aspirin with dipyridamol or 5% dextrose were administered to 266 patients admitted to the coronary unit with unstable angina. All patients were concurrently treated with isosorbide dinitrate, a beta-blocker and nifedipine. The number of patients who developed an acute myocardial infarction (IM) during the subsequent 72 hours was comparable in all three groups. However, in the heparin treated group only 3.2% patients developed Q IM, as compared with 20% patients treated with aspirin and dipyridamol (p = 0.005) and with 19% in the control group (p = 0.006). The magnitude of the IM was evaluated according to the highest serum value of creatine...

[Detection of atrial septal defects using esophageal echocardiography].

J Novotný, K Hlavácek, M Sístek, T Vaněcek, J Fiserová

Vnitr Lek 1990, 36(6):544-547

By means of transoesophageal (oesophageal) echocardiography (TEE) the authors examined a group of 20 subjects. In 10 there was clinical suspicion (physical finding, ECG, X-ray) of an atrial septal defect. Common precordial echocardiographic examination (TTE) and dilution of indocyan green by means of an acustic sensing unit were negative or only marginally positive and did not provide a final decision. By means of TEE the defect was confirmed in 8 subjects by the finding of anatomical discontinuity of the septum and the presence of coloured Doppler shunt flow. In two subjects the finding was negative, in 10 controls no pathological findings were detected....

[Diagnosis of acute dissection of the aorta].

F Kovár, R Dálik, J Hrnciar, A Kreze, A Buková, S Okapec, P Dědic

Vnitr Lek 1990, 36(6):548-553

The authors present a group of 14 patients (9 men and 5 women) aged 38-76 years (mean age 59 years) who were hospitalized during the five-year period between 1984 and 1988 at the medical department A of the Regional Institute of National Health in Banská Bystrica on account of acute dissection of the aorta. The authors describe clinical manifestations which can lead to suspicion of this serious disease. They make the readers familiar with their experience with ultrasonic and X-ray examination (in particular aortography and computed tomography). They analyze their contribution to the diagnosis of acute dissection of the aorta.

[Cardiac function and adrenergic regulation in incipient hyperthyroidism].

V Vavrejnová, J Nedvídková, J Bednár, A Simecková

Vnitr Lek 1990, 36(6):554-559

The authors investigated in 14 euthyroid women the action of triiodothyronine administered for 7 days, 100 micrograms per day. It was revealed that after the administration of triiodothyronine the duration of the preejection period of the systole was reduced as well as the index of the preejection period and the index of the electromechanical systole, and the weight declined. At the same time the authors recorded a drop of the plasma noradrenaline and adrenaline level, of the serum cholesterol and thyroxine concentration. The serum triiodothyronine level increased and correlated inversely with the duration of the preejection period. Triiodothyronine...

[Comparison of 2 methods for determination of antibodies to thyroglobulin in clinical practice].

E Trunecká, B Bednár, J Havelka, J Němec, M Soutorová, V Zamrazil

Vnitr Lek 1990, 36(6):560-565

The authors compared the results of two methods for the estimation of antibodies against thyroglobulin: the principle of the Thymune-T test (Wellcome) is a haemagglutination method; parallel examinations were made by the author's modification of the radiochemical coprecipitation test (RCT). The laboratory results were evaluated in a large clinical group of patients with different types of thyroid disease. It was confirmed that the haemagglutination method gives more frequently positive results than the radiochemical test, in particular in the range of low titres. The chi square test provided, however, evidence that between methods a significant correlation...

[Subclinical hypothyroidism].

S Vána, J Földes, J Němec, V Zamrazil, J Bednár, J Zimák

Vnitr Lek 1990, 36(6):566-572

Subclinical hypothyroidism was detected in 5.7% of 853 patients referred for ambulatory examination to a department in Prague. In patients referred with a mild degree of subclinical hypothyroidism with an evaluated level of thyrotropic hormone in serum (TSH) no significant deviations of serum thyroxine and triiodothyronine (T4 and T3) were found nor different values of the Achilles tendon reflex time, as compared with patients with normal thyroid function. In case of a more marked grade of subclinical hypothyroidism with an elevated TSH level without stimulation the patients have on average significantly lower T4 vales, significantly longer Achilles...

[Campylobacter pylori and treatment of duodenal ulcer].

J Zelenková, R Toman, M Bielaszewská, J Hanika, V Zeman

Vnitr Lek 1990, 36(6):573-579

The authors subjected to endoscopic examination 90 patients with duodenal ulcers. From each patient they collected a bioptic specimen of the gastric antrum and duodenal bulbus for microbiological and histological examination. They found that for detection of C. pylori the microscopic examination was most useful. The presence of C. pylori in the gastric antrum was detected in 87% of the subjects and in the duodenal bulb only in 48%. The difference is significant at the 0.01 level. To 43 patients of the group Ranitidine was administered. The ulcer was cured within 4 weeks in 35 subjects. Ranitidine did not affect the presence of C. pylori and antral...

[Tenoxicam in the long-term treatment of active rheumatoid arthritis].

J Vachtenheim

Vnitr Lek 1990, 36(6):580-585

The authors present the results of six months treatment with Tenoxicam (Tilcotil) in 30 patients with active rheumatoid arthritis. In no instance was it necessary to discontinue treatment, only one female patient complained of transient vertigo. During the final evaluation of the therapeutic effect as regards painfulness, sensitivity on palpation, oedema, restriction of movements, the author did not observe a satisfactory effect only in 8.5-24%. As regards hand grip, 20 m walk and consumption of analgesics the effect was also very satisfactory. Only four patients used occasionally Paracetamol or Alnagon, 1-2 tablets per day. The results achieved with...

[An unusual case of prolonged hypoglycemia].

Z Svoboda

Vnitr Lek 1990, 36(6):586-589

The author described a case of protracted hypoglycaemia in a young type I insulin treated diabetic, associated at first with neurological symptomatology imitating a cerebrovascular attack. After three days, when it was necessary to administer repeatedly glucose by the i.v. route on account of low blood sugar levels, the carbohydrate metabolism deteriorated and called for administration of similar insulin doses as before. In the discussion the author deals with pathogenetic possibilities of the described condition.

[Pathogenic aspects of diabetic macroangiopathy].

I Tkác

Vnitr Lek 1990, 36(6):590-596

Diabetics of both types suffer more frequently from atherosclerosis of the coronary, cerebral and peripheral arteries than the non-diabetic population of similar age groups. In the pathogenesis of atherosclerosis in diabetes an important part is played by the very frequent association of the diabetic syndrome with hyperlipoproteinaemia and hypertension, elevated levels of substances potentially toxic for the endothelium such as glucose, chylomicron remnants, sorbitol, immunocomplexes, CO and others. Changes of thrombocyte functions and of the equilibrium of the system prostacycline-thromboxane as well as disorders at different sites of the haemocoagulation...

[Treatment of hyperglycemic coma states in diabetics].

J Kmoch

Vnitr Lek 1990, 36(6):597-601

In the treatment of acute decompensation of diabetes, diabetic ketoacidosis and hyperosmolar non-acidotic syndrome the basic demand is insulin administration--in small doses by the i.v. route, preferably by means of an injectomat in a permanent infusion. An alternative method for departments which do not possess a suitable infusion pump, is fractionated administration of small insulin amounts into the vein after 30 minute intervals. Equally important is rehydration treatment with saline; only in case of hypernatriaemia above 150 mmol/l the author recommends 0.45% NaCl. Acidosis in DKA is corrected by sodium bicarbonate only at pH 7.1 or less. As to...

[Treatment of acute pulmonary edema].

M Lomícek, S Pejchl, G Berlinger

Vnitr Lek 1990, 36(6):602-608

The authors give an account of treatment of acute pulmonary oedema. Their account is based on contemporary data in the literature and their own experience. Some aspects of the therapeutic procedures are described in detail. The review should serve as a practical guide for doctors not concerned in particular with the treatment of acute states.

[The significance of rehabilitation in angiology].

V Puchmayer

Vnitr Lek 1990, 36(6):609-614

The author draws attention to the important position of different types of rehabilitation in the treatment of arterial, venous and lymphatic diseases. He mentions also different methodical procedures in the listed diseases. He emphasizes that rehabilitation, in particular intensive interval training, remains the main therapy of ischaemic disease of the lower extremities.

[Use of nonparametric methods in medicine. I. Introduction].

A Gerylovová, J Holcík

Vnitr Lek 1990, 36(6):615-618

This is the introductory article of a series of eight where the authors discuss non-parametric methods. They compare the advantages and disadvantages of non-parametric methods with parametric ones. Non-parametric methods can be used in particular where the investigated variables do not have a normal distribution, where the small size of the investigation and the type of classification do not permit to test, when information on the investigated variables are presented by means of rank or normal scales etc. Their disadvantage is a smaller ability to refute the null hypothesis, when it is not correct, as compared with parametric tests.

[Prof. Julius Markovic, an outstanding patriot and physician].

V Krislo, O Masek

Vnitr Lek 1990, 36(6):619-621