[Clinical problems in non-A, non-B viral hepatitis. I. Diagnosis of non-A, non-B viral hepatitis and its role in the occurrence of acute viral hepatitis in the Czechoslovak population].

P Jezek, P Chalupa, P Horký, I Capovová, I Kolácný, Z Horák

Vnitr Lek 1990, 36(12):1145-1150

Using RIA and ELISA methods the authors examined HBsAg, anti-HBc IgM and anti-HAV IgM antibodies in 830 adult patients and 101 children with acute viral hepatitis from the catchment area of the South Moravian region. In these groups also the most frequent hepatotropic infectious agent as the possible cause of hepatitis was examined. It was revealed that in adults viral hepatitis A accounted for 22%, viral hepatitis B for 48.5%, viral hepatitis non-A, non-B for 28.8% of the group. The percentage distribution of viral hepatitis in children is different: hepatitis A predominates (65%), hepatitis B is less frequent (22%) and viral hepatitis non-A, non-B...

[Clinical problems in non-A, non-B viral hepatitis. II. Clinical picture of non-A, non-B viral hepatitis in the acute stage].

P Jezek, P Chalupa, I Kolácný, Z Horák

Vnitr Lek 1990, 36(12):1151-1157

Comparison of large groups of patients with acute viral hepatitis A (HA), B (HB) and non-A, non-B (HNANB) revealed that the highest percentage of anicteric forms is found in HA (44.8%) followed by HNANB (27.3%) and the lowest percentage in HB (23.6%). Investigation of mean values of biochemical functional liver tests showed that 1. the highest mean values of bilirubinaemia, ALT and AST were recorded in HB. The differences are statistically significantly higher (p less than 0.01) than in the two remaining types. 2. The difference between the cholesterol serum level, GMT and ALP in HB and HNANB on the one hand and HA on the other hand was at the same...

[Clinical problems in non-A, non-B viral hepatitis. III. The course of non-A, non-B viral hepatitis in the chronic stages].

P Jezek, P Chalupa, J Horecká, I Kolácný, Z Horák

Vnitr Lek 1990, 36(12):1158-1163

Investigation of a group of 231 patients with viral hepatitis non-A, non-B (HNANB) revealed that the majority of cases is of the parenteral type (60.17%) and the remainder was without parenteral procedures. The course of HNANB was icteric in the majority (72.55%). On check-up examination one year after the onset of the acute stage the pathological clinical and laboratory finding, i.e. chronic liver disease still persisted in 31.6%. A follow-up of the patients in the course of six years revealed that the ratio of serious sequelae (chronic active hepatitis and cirrhosis of the liver) is significant and increases with time and thus already after two years...

[Essential phospholipids in the treatment of chronic hepatitis B virus infection].

I Hanták, M Boca, M Mikulecký, D Stancek

Vnitr Lek 1990, 36(12):1164-1171

The authors investigated 24 patients with chronic infection with the hepatitis B virus. HBeAg-positive patients had significantly (alpha = 0.05) more frequently pathological initial values of biochemical and immunological indicators, as compared with anti-HBe-positive patients. Delta antigen in the liver and anti-delta antibodies in serum if examined, were always negative. All patients were subjected to 16-week treatment with Essentiale forte (Natterman). After treatment and after the subsequent 16 weeks in none of the patients loss of HBsAg or seroconversion of HBeAg-positive to anti-HBe-positive was recorded. In the sub-group of HBeAg-positive subjects...

[Prevention of viral hepatitis B transmission in the transplantation program].

M Kselíková, J Urbánková

Vnitr Lek 1990, 36(12):1172-1176

The authors discuss possible detection of HBsAg with regards to demands of the transplantation programme. They compared the sensitivity of HBsAg detection by ELISA on kits of various firms, using a panel of sera previously examined by the RIA technique. The most sensitive and most rapid answer on the presence of a surface antigen of the hepatitis B virus by the ELISA technique can be obtained using a Wellozyme kit of Wellcome Diagnostics Co., i.e. within 60 minutes. The firm must, however, equip the kits with double volumes of positive and negative controls.

[Chronic persistent cough and gastroesophageal reflux].

M Puchala

Vnitr Lek 1990, 36(12):1177-1181

Respiratory complications of gastrooesophageal reflux are not rare. Their incidence is estimated to amount to as much as 20%. Chronic persisting cough as one of the respiratory complications of gastrooesophageal reflux is relatively rare (28%) but frequently is not assumed to be causally related to the reflux. The author attempted to elucidate this problem by description of individual cases and to find at the same time the most rational solution, as some procedures are, as regards availability of examination methods, costly and time consuming.

[Classification of colorectal adenomas based on the histological picture in patients without symptoms].

V Zoubek, M Mrůzek

Vnitr Lek 1990, 36(12):1182-1184

During screening of colorectal carcinoma by the test of occult haemorrhage in 1985 to 1989 in the Bruntál district during coloscopic examination of positive subjects a total of 277 adenomatous polyps of the large intestine were revealed. Adenomatous polyps were detected in 227 patients where by in 180 solitary polyps were involved and in 47 cases synchronous polyps. 222 adenomatous polyps were in the rectum and left half of the colon (80.1%). Histological examination revealed: tubular adenoma 153 cases (55.23%), tubovillous adenoma 92 cases (33.21%), villous adenoma 13 cases (4.69%), adenoma with intramucous carcinoma 12 cases (4.43%) and adenoma with...

[Silent stress ischemia in patients after aortocoronary bypass].

J Meluzín, M Novák, L Spinarová

Vnitr Lek 1990, 36(12):1185-1190

In a group of 37 patients with chronic stable angina the authors compared results of bicycle ergometry after a load before and after coronary artery bypass grafting. The group included only patients who had to terminate initial ergometry performed during the last two months before operation on account of stenocardia and signs of myocardial ischaemia on the ECG tracing. On average 20 months after coronary artery bypass grafting ergometry was repeated. Nineteen patients (51%) lacked electrocardiographic signs of myocardial ischaemia, 18 patients (49%) suffered from ischaemia after a load (depression S-T greater than or equal to 2 mm). Of these in 18...

[Coronary score and risk indicators].

O Kusá, M Mikulecký, I Riecanský, P Ondrejka

Vnitr Lek 1990, 36(12):1191-1196

Using the method of multi-dimensional statistical analysis in the evaluation of relations between the coronary score and risk factors in 120 men with ischaemic heart disease type stable angine, and in 30 men in a control group the authors revealed: age is a significant negative discriminator of the presence and indicator of the severity of atherosclerotic narrowing of the coronary arteries, cholesterol is a statistically significant positive independent discriminator of the presence and indicator of the severity of atherosclerotic narrowing of the coronary arteries, HDL-cholesterol is a significant negative independent indicator of the severity of...

[Changes in hemostasis in blood donors on the Fenwal CS 3000 separator].

H Pittrová, V Koza, V Cepelák, L Vít

Vnitr Lek 1990, 36(12):1197-1202

During thrombocytophereses on a blood cell FENWAL CS 3000 separator in one group of donors the anticoagulant solution ACD-A recommended by the manufacturer was used, in the other group of donors ACD-A with heparin was used. The authors give an account of the changes in some parameters of haemostasis in these donors on the separator incl. examination of fibrinopeptide A which is the most sensitive indicator of clotting activity during separation. Heparin administration prevented a rise of fibrinopeptide A and did not lead to a reduced platelet yield.

[Secondary osteopenia].

J Kocián

Vnitr Lek 1990, 36(12):1203-1209

A total of 2484 newly detected metabolic bone diseases during the past 17 years comprised 79.67% cases of osteoporoses and 20.33% of osteomalacia. The group of osteoporoses included 325 patients (16.43%) with the primary form of the disease, in 1654 patients (83.57%) a cause of decalcification of bones (secondary form) was found. With advancing time the number of secondary osteoporoses rises steadily, while the number of primary cases remains at the same level. In the aetiology of demineralization a major part was played by lactose intolerance, maldigestion and malabsorption, idiopathic, hypercalciuria, diabetes and steroids. The female: male ratio...

[Illness in the life of General (Dr.) Milan Rastislav Stefánik].

V Krislo, M Krislová

Vnitr Lek 1990, 36(12):1215-1217