Vnitřní lékařství, 1990 (vol. 36), issue 11
[Anticardiolipin antibodies in diffuse connective tissue diseases with IgG, IgM and IgA isotypes].
Z Hrncír, V Chýlková
Vnitr Lek 1990, 36(11):1041-1049
Anticardiolipin (aCL) antibodies were assessed in isotypes IgG, IgM and IgA by the enzyme immunochemical technique in serum of 86 subjects with diffuse connective tissue affections and in 75 subjects of three control groups (syphilis, syndrome of common variable immunodeficiency and blood donors). In systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and syphilis the mean values of the three isotypes of aCL antibodies were significantly higher than in blood donors (p = 0.05 to 0.001); in diffuse scleroderma and primary polymyositis/dermatomyositis in isotype IgG (p = 0.01-0.001). Positive findings of aCL antibodies (isolated or in combinations...
[Why are there anti-cardiolipin antibodies in patients with infectious mononucleosis and in patients with systemic lupus erythematosus?].
C Dostál, A Palecková, M Novák, M Jahn, C Dostál
Vnitr Lek 1990, 36(11):1050-1056
The phenomenon of anticardiolipin antibodies (aCL) is in recent years the subject of interest as it is connected with manifestations of thromboses at different sites, with repeated miscarriages in pregnant women and with thrombocytopenia. As compared with the original finding in patients with systemic lupus erythematosus (SLE), the authors find they are present also in infection with the Epstein-Barr virus--in patients with acute infectious mononucleosis, in as many as 61% of a total number of 77 examined patients; in a group of 60 patients with SLE in 41% and in a group of healthy controls in 3.9%. aCL differ, however, as regards the distribution...
[Possibilities of dialysis therapy in irreversible renal failure in rheumatoid arthritis with secondary amyloidosis].
J Vachtenheim, J Tocík, Z Novák, P Zeman
Vnitr Lek 1990, 36(11):1057-1061
The authors discuss their initial experience with the treatment of secondary amyloidosis in rheumatoid arthritis with irreversible renal failure in patients included in a regular dialyzation programme. The hitherto assembled 15-month experience justifies the inclusion of patients with this cause of irreversible renal failure in a dialyzation programme. The reverse is not only wrong from the medical aspect but is inhuman and interferes with the life of families of these patients. Although the procedure during a regular dialyzation programme of these patients with rheumatoid arthritis with secondary amyloidosis is more complicated, more pretentious and...
[Levels of tetra-, triiodothyronine and thyroid stimulating hormone in patients with rheumatoid arthritis].
M Kucera, H Brabcová
Vnitr Lek 1990, 36(11):1062-1065
The authors made in patients with confirmed or classical rheumatoid arthritis, using RIA, functional tests of the thyroid gland, i.e. tetra-, triiodothyronine and thyroid stimulating hormone. While deviations of tetraiodothyronine levels from normal very rare, a reduction of triiodothyronine was recorded in 50% and of TSH in 27.2%. Clinically manifest thyropathy, i.e. hyperthyroidism was found only in one female patient. The authors investigated changes in the values of the above tests in the course of rheumatoid arthritis and a dysbalance in the regulation of thyroid functions. The investigation comprises also a group of 18 subjects with rheumatoid...
[A 5-year study of cardiac involvement in polymyositis/dermatomyositis].
P Bradna, M Pospísil, J Vizďa, F Duska
Vnitr Lek 1990, 36(11):1066-1071
Improvement of the diagnosis and new therapeutic opportunities revealed a number of organ affections also in patients with polymyositis and dermatomyositis. One of the prognostically important organ manifestations is affection of the heart. The prospective investigation comprises 15 patients with a confirmed diagnosis of polymyositis (10) or dermatomyositis (5). The investigation, using a number of non-invasive method (ECG, echocardiography, systolic time intervals, 99mTc pyrophosphate scan of the heart muscle), proved in the course of the 60-month investigation an increase of pathological findings from 40% at the onset (6/15) to 6 from 11 surviving...
[Cytogenetic study in multiple myeloma. I. Chromosome findings in 56 patients].
M Jarosová, V Scudla, K Indrák, M Kapustová
Vnitr Lek 1990, 36(11):1072-1080
The authors submit the results of cytogenetic examination of 56 patients with multiple myeloma. Chromosome changes were found in 25, i.e. 45% patients. Structural changes were found most frequently in chromosomes no. 1, 11 and 14, numerical changes in chromosomes 3, 4, 9, 11, 14, 16, 19, 21, 22, X and Y. Marker chromosomes were present above all in hyperdiploid mitoses. The authors did not detect a relationship of chromosome changes and the type of produced monoclonal immunoglobulin, nor a statistically significant difference in the frequency of chromosomal changes in treated and untreated patients. Hyperploidy and complex rearrangements of chromosomes...
[Cytogenetic study in multiple myeloma. II. Clinical significance of chromosomal changes].
V Scudla, M Jarosová, M Kapustová, K Indrák
Vnitr Lek 1990, 36(11):1081-1091
The authors evaluated in a group of 56 patients with multiple myeloma the clinical impact of assessed chromosomal changes. They found a close relationship between the frequency of chromosomal deviations and the extent and activity of the disease. The authors did not detect a relationship between the frequency of karyotypic changes and the number of plasmocytes in bone marrow nor a significant difference in the incidence of hypodiploidy in different immunochemical types of multiple myeloma. Patients with chromosomal changes had a reduced response to cytostatic treatment. The authors revealed a prognostic importance of chromosomal changes, in particular...
[Validity of biochemical examinations in ascites in clinical practice].
L Vladár, R Pullmann, J Květenský, M Valentík, I Katuscák, I Markuljak
Vnitr Lek 1990, 36(11):1092-1101
The authors examined, using biochemical, cultivation and cytological methods, ascites in 94 patients. They divided the patients into four groups: group 1 (36 patients)--malignant ascites, group 2 (35 patients)--cirrhotic ascites, group 3 (11 patients)--cardial ascites, group 4 (12 patients)--nephrogenic ascites. The authors tried to differentiate malignant ascites from non-malignant, based on biochemical parameters. As the composition of ascites is influenced by some factors (diuretics, dialysis) the authors recommend the use of biochemical analyses of ascites in clinical practice.
[Side-effects of continuous and discontinuous cytapheresis].
E Fehérvízyová, K Sviteková, M Hrubisko
Vnitr Lek 1990, 36(11):1102-1107
The authors evaluate the incidence of complications in 767 cytapreheses made on two types of blood cell separators. Complications, incl. technical problems before cytapheresis proper, were encountered more frequently during work with the discontinuous blood cell separators Haemonetics model 30 (27.%) than during work with the continuous automatic blood cell separator Fenwal CS 3000 (13.2%). Most frequently collapse and symptoms of hypocalcaemia were involved. Serious reactions account only for 7.6 and 4.4% of all reactions. The authors discuss the causes and possible prevention of complications during cytapheresis. With regard to the assessed results...
[Is accurate dosing possible using infusion sets?].
J Spinar, J Vítovec, M Stejfa
Vnitr Lek 1990, 36(11):1108-1112
The authors discuss factors which influence the dispensing of infusion solutions by means of infusion sets regulated by a button. They draw attention to the fact that by means of infusion sets IS 103 and TS 203 accurate dispensing is not possible as the rate of flow changes markedly with the time of administration of the infusion. On the other hand, in the EXADROP dispenser marked slowing down of the infusion in relation of time does not occur and the authors recommend it therefore for common use in standard departments.
[Microcirculation in the subcutaneous layer and in muscles in diabetes mellitus].
A Lacko, A Kreze, J Pechán, Z Putz, G Fodor, J Velemínský
Vnitr Lek 1990, 36(11):1113-1118
The work is focused on the possibility of early diagnosis of diabetic microangiopathy. The authors used examination of microcirculation by the method of tissue clearance of Na 131I. In a group of 106 patients with diabetes thus the microcirculation of the lower extremities in the subcutaneous layer and the calf muscle was examined. A group of 36 healthy subjects served as control. An altered microcirculation was found in 75% type 1 diabetics and in all type 2 diabetics. In those with an altered microcirculation only in 23% type 1 diabetics and in 17% type 2 diabetics organ manifestations of diabetic microangiopathy (i.e. retinopathy and nephropathy)...
[Puncture biopsy of the joint--contribution to research on the joint milieu].
M Vykydal, M Lindusková
Vnitr Lek 1990, 36(11):1119-1122
The authors deal with articular needle biopsy with regard to the extension of knowledge and research of the articular environment. Articular biopsy is indicated in diseases associated with an articular exudate. It is made most frequently on the knee joint. In some diseases the histological picture of the articular lining is typical for the diagnosis, in some it is at least characteristic. In some instances an unequivocal interpretation of the histological finding is rather dubious from the diagnostic aspect. Needle biopsy of the joint is confronted with other findings and the clinical picture. Articular needle biopsy can be used for detection of therapeutic...
[Suggestions for criteria for uniform evaluation of changes in the spine in vertebral dysostosis of the Scheuermann type].
J Beran
Vnitr Lek 1990, 36(11):1123-1126
The author recommends in his proposal of uniform criteria to evaluate pathological changes of the spine according to a pattern where the first place is held by morphological changes (unevenness of the covering plates, changes in the shape of bodies of the vertebrae, changes in the height of disc and changes in the curvature of the spine). The second place in held by functional changes and the third one by the general extent and quality of pathological changes. In the latter group the author draws attention to the appearance of a stigmatized spine. It is essentially an abortive form of vertebral dysostosis with frust not very marked morphological symptoms....
[Aspects of treatment of hypertension in rheumatic diseases].
S Alusík
Vnitr Lek 1990, 36(11):1127-1131
The author deals with the reasons of the frequent incidence of hypertension in rheumatic diseases and some special aspects of its therapy (nephrogenic hypertension in systemic diseases, weakening of the action of antihypertensive drugs by nonsteroidal antiinflammatory drugs, chronic corticosteroid treatment and the unsuitability of some antihypertensive drugs in different rheumatic diseases).
[Use of nonparametric methods in medicine. VI. Evaluation using dependence by rank].
A Gerylovová, J Holcík
Vnitr Lek 1990, 36(11):1132-1138
The authors deal with the evaluation of dependence between two quantitative variables. They analyze Spearman's and Kendall's rank correlation coefficients. The procedure is explained on examples. Decision taking between the zero and alternative hypothesis is made possible by the enclosed tables of critical values. When the number of data is higher than 30, the significance of the two coefficients can be evaluated by means of the testing characteristic with a normal distribution.