[Comparison of the QRS score and the left ventricular ejection fraction in patients after acute myocardial infarct].

S Janousek, S Stěpánková, I Janousková

Vnitr Lek 1989, 35(5):417-424

In 90 subjects, mean age 52 +/- 9 years with a first acute myocardial infarction (AIM) the authors evaluated the QRS score by Wagner's method. The assembled values were compared by linear regression with values of the ejection fraction (EF) of the left ventricle (LV), calculated according to Dodge's method from left-sided ventriculography made during the same period (on average 45 +/- 9 days after the development of AIM). For the entire group a correlation r = -0.43 (p less than 0.001) was obtained, for the sub-group of patients with AIM of the anterior wall (n = 44), r = -0.57 (p less than 0.001), correlation was found in patients with AIM of the...

[Comparison of changes in the mobility of the left ventricular wall with coronarographic findings in patients after myocardial infarct].

L Elbl, V Chaloupka, R Soucek, S Janousek, J Toman, J Zák

Vnitr Lek 1989, 35(5):425-432

The authors examined by echocardiography at rest and after exertion a group of 55 patients after a clinically confirmed first transmural infarction. They compared the echocardiographic findings with coronarographic ones. The finding at rest, as regards impaired mobility of the left ventricular wall, corresponded to the clinical finding and the coronarographic finding. By diagnosis of the extended asynergy of contraction during an isometric load it was not possible to differentiate the functional and organic cause of impaired mobility and thus to assess the extent of the coronary affection. The impaired mobility of the left ventricular wall is associated...

[Diagnosis of myocardial ischemia using functional ST mapping and 201Tl stress scintigraphy].

M Janota, J Kasalický, J Lexa, J Stupka, J Fabián

Vnitr Lek 1989, 35(5):433-438

The authors compared the value of two non-invasive methods in the diagnosis of myocardial ischaemia, i.e. precordial working maps of the ST segment and working scintigraphy of the myocardium with 201T1 after a load. On comparison with the finding on the coronary arteries, the authors found a high sensitivity of mapping, 89.3%, and of 201T1 scan, 92.9%, while the specificity of both methods was lower, 57.1%. Both methods are equally valuable for diagnosis of myocardial ischaemia; for assessment of the site of affection thallium scintigraphy of the myocardium is preferable.

[Diltiazem VUFB (Diacordin Spofa) in the treatment of arterial hypertension].

J Zicha

Vnitr Lek 1989, 35(5):439-444

In an eight-week open clinical investigation controlled by placebo in 21 hypertonic patients the author tested the calcium ion antagonist produced in Czechoslovakia, Diltiazem, VUFB. Its very favourable antihypertensive action was proved in patients with arterial hypertension stage I and II (according to WHO), using a maximal daily dose of 180 mg without the need of combination with other antihypertensive drugs, incl. diuretics. The undesirable effects were mostly weak and developed during the first 12 days of administration of the drug. Then they disappeared. Only two patients discontinued treatment on account of severe subjective complaints. In the...

[Electrophysiologic properties of diltiazem VUFB tablets: effect on atrioventricular conduction].

A Mádle, J Vainer, J Kudová, J Smíd, J Mastálka

Vnitr Lek 1989, 35(5):445-451

The authors investigated the action of a single oral dose of the recently developed preparation Diltiazem VUFB tabl. on electrophysiological parameters of atrioventricular conduction - the AH, HV interval, Wenkebach's point and the relative, functional and effective refractory period of the atrioventricular node. The preparation affects significantly parameters of the level of the node and its effect is comparable with data on the action of diltiazem produced abroad.

[Antihypertensive therapy using metipamide VUFB].

K Sedláková, R Dzúrik

Vnitr Lek 1989, 35(5):452-459

In a group of 17 patients with mild hypertension the antihypertensive effect of Metipamide VUFB was investigated. In the course of fourteen weeks' treatment the mean blood pressure declined from 20.5/13.3 kPa to 17.3/11.2 kPa and at the end of the investigation the diastolic blood pressure readings were normal in all patients. Echocardiography revealed a slight decline of the total peripheral resistance. The natriuretic effect was confirmed which is in the foreground of the antihypertensive action of metipamide. Investigation of side-effects of treatment revealed in 12 patients hypokaliaemia calling for substitution treatment, or when used clinically,...

[Angioimmunoblastic lymphadenopathy--present problems].

I Krc, J Macák, J Zádník

Vnitr Lek 1989, 35(5):460-466

Angioimmunoblastic lymphadenopathy is usually characterized as a lymphoproliferative disease caused by an abnormal reaction to various chemical and biological antigens and the possible development into malignant lymphomas of different types. The authors evaluate clinical and laboratory findings in a group of their patients suffering from the above disease. They emphasize the variable symptomatology, the frequently atypical course and the ensuing diagnostic difficulties.

[Natural HLA-A, B and DR antibodies in the serum of non-immunized men].

A Májský

Vnitr Lek 1989, 35(5):467-471

From 643 sera of healthy women and men in 67 a positive reaction with B lymphocytes and/or monocytes of healthy subjects was found. Forty-seven sera gave only occasional weak reaction. Twenty sera were from 18 subjects (13 men without a transfusion in the case-history 5 women with pregnancy in the case-history). In nine sera of men (= 1.40%) HLA-A, B cytotoxins, usually bi-or multispecific, were detected, in four sera of men (= 0.62%) HLA-DR antibodies were present in two instances their specificity was assessed: anti-HLA-DR7, anti-HLA-DRI + weak DR4. All these antibodies can be considered natural. In three women HLA-A, B cytotoxins were detected,...

[The incidence of occupational diseases in the health services within the catchment area of the Clinic for Occupational Diseases of the School of Medicine in Prague].

D Kuklová, M Kneidlová, M Mencík, A Naus

Vnitr Lek 1989, 35(5):472-478

The authors analyzed notified occupational diseases at the department of occupational diseases during the 10 past years, focusing attention on workers in the health workers' union. The highest ratio is that of viral hepatitis (64.8%) and skin diseases (14.7%). These are followed by other infectious diseases, tuberculosis, asthma bronchiale, etc. The largest number of occupational diseases was reported in female health workers (74.7%) which is consistent with nationwide data on occupational diseases. The high ratio of women is not surprising with regard to the marked feminization of this occupation. The highest ratio of occupational diseases was reported...

[Elevated indicators of liver metabolism in patients with giardiasis].

V Krcméry, M Brix, E Gocár, J Goljer, K Gecík

Vnitr Lek 1989, 35(5):479-482

The authors present an account on 60 patients where, based on the clinical picture, parasitological examination and laboratory parameters, the diagnosis of giardiasis was established. Among these patients a rise of one or several indicators of liver metabolism was found in 31%. The authors discuss whether the above conditions can be considered hepatitis within the framework of the basic parasitic disease. They eliminated non-parasitic causes (obstruction, HBsAg positive hepatitis, drug hepatitis, toxic hepatopathies) of elevated transaminase and bilirubin levels. For collection of duodenal juice or faeces for parasitological examination they used a...

[Löffler's endocarditis].

J Pella, J Lazúr, B Stancák, G Matejícková, A Pellová, I Schréter

Vnitr Lek 1989, 35(5):483-488

The authors describe Loeffler's endocarditis and the treatment of this clinical entity. Among diagnostic methods which drew attention to a cardiac affection associated with eosinophilia, non-invasive examination methods were of decisive importance. They comprised conventional electrocardiographic examination, X-ray of the chest and two-dimensional echocardiography.

[An unusual chronic myeloproliferation].

E Kolesková, J Háber, P Klener

Vnitr Lek 1989, 35(5):489-492

The authors draw attention to possible difficulties associated with the accurate diagnosis of myeloproliferative conditions. On the example of two patients they demonstrate the abnormal course of the disease reminding in one case of chronic myeloid leukaemia and in the second case of the myelofibrotic syndrome. Even detailed and repeated laboratory examinations incl. cytochemistry, cytogenetics, trepanobiopsy and cultivation of haemopoietic stem cells did not contribute to accurate assessment of the diagnosis. The picture of inexplicable myeloproliferation associated with a favourable clinical condition persists for 26 years in one patient and 12 years...

[The calcium signal in the physiology of the secretory process. I].

I Zofková

Vnitr Lek 1989, 35(5):493-500

The author gives an account of contemporary knowledge and hypotheses on the role of calcium as the second messenger signalizing stimulation of the secretory cell by a specific secretagogue stimulus. The basic structures from which calcium ions are released into the cytosol are the endoplasmatic reticulum, secretory granules and the cell membrane. The author discusses also the importance of mitochondria which act as an intracellular calcium reservoir. An important source of calcium for activation of the secretory process is also the extracellular space. Oscillation of the electric tension of the membrane of the excitable cell which causes temporary...

[The calcium signal in the physiology of the secretory process. II. The effect of extracellular and intracellular calcium on secretory mechanisms].

I Zofková

Vnitr Lek 1989, 35(5):501-506

Investigations of the influence of the extra- and intracellular calcium source on secretory processes helps the understanding of the physiology and pathophysiology of secretion. The ratio of the two calcium sources in the activation of secretion depends on the type of secretory cell, on the character of the secretagogue stimulus and the phase of the secretory process. The use of intracellular sources of calcium in the early stage of secretion explains the lack of an inhibitory action of calcium current blockers on the function of some hormonal systems in short-term studies, e.g. the tyrotropic and somatotropic system, or on adrenocortical secretion....

[Dr. Karel Amerling--physician, scientist, teacher and Purkinje scholar].

D Zavadilová

Vnitr Lek 1989, 35(5):508-511