Vnitr Lek 2025, 71(4):235-240 | DOI: 10.36290/vnl.2025.043

Gliflozins - the nephrologist's point of view

Petr Táborský

Interní klinika 3. lékařské fakulty Univerzity Karlovy a Fakultní Thomayerovy nemocnice, Praha

Affidea Praha, s. r. o.

Gliflozins are a group of agents that were originally marketed as antidiabetic drugs, but later several studies demonstrated their beneficial effect in heart failure and chronic kidney disease. Their introduction into practice has allowed early treatment of these diseases and a reduction in their late complications. In nephrology they are applied as nephroprotective agents, diuretics and treatment of cardio-renal syndrome. Nephroprotection means not only delaying end-stage renal failure but also reducing the incidence of cardiovascular complications associated with renal dysfunction. The use of gliflozins as a diuretic allows for a reduction in the dose of loop diuretics and thus reducing the risk of their adverse effects. Early treatment of heart failure prevents the development of cardio-renal syndrome, which is a frequent cause of hospitalization. Finally, the use of gliflozins has forced physicians to go beyond the boundaries of their narrow specialties and see metabolic-cardio-renal syndrome as a disease that can occur in different forms but still have a common treatment.

Keywords: gliflozins, cardio-renal syndrome, chronic kidney disease, nephroprotection.

Accepted: June 3, 2025; Published: June 19, 2025  Show citation