Vnitr Lek 2024, 70(8):522-527 | DOI: 10.36290/vnl.2024.099

DRESS syndrome as a probable cause of acute kidney injury and skin involvement in a polymorbid patient

František Novák1, Jiří Vymětal2, Petr Konvička3
1 Interní oddělení Podhorské Nemocnice Agel Bruntál
2 III. interní klinika - nefrologická, revmatologická a endokrinologická, Fakultní nemocnice Olomouc
3 Gastroenterologické oddělení Nemocnice Agel Prostějov

DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a severe late drug reaction, which can be potentially life threatening. It usually manifests itself as a whole-body exanthema, changes in blood count and organ involvement, especially the liver and kidneys. Here, we describe a case of a polymorbid elderly patient with skin involvement and renal failure related to the use of allopurinol. Early diagnosis and adequate treatment led to restoration of renal function. Eosinophilia was a crucial diagnostic indicator.

Keywords: DRESS syndrome, allopurinol, renal failure, exanthema, polymorbidity, eosinophilia.

Accepted: November 27, 2024; Published: December 18, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Novák F, Vymětal J, Konvička P. DRESS syndrome as a probable cause of acute kidney injury and skin involvement in a polymorbid patient. Vnitr Lek. 2024;70(8):522-527. doi: 10.36290/vnl.2024.099.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bocquet H, Bafot M, Roujeau JC. Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg. 1996 Dec;15(4):250-257. Go to original source... Go to PubMed...
    2. Calle AM, Aguirre N, Ardila JC, et al. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organization Journal 2023 16:100673 http:/doi.org/1,1016/j.waojou.2022.100673. Go to original source... Go to PubMed...
    3. Choudhary S, McLeod M, Torchia D, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol. 2013 Jun°6(6):21-37.
    4. Shiohara T., Kano Y. Drug reaction with eosinophilia and systemic symptoms (DRESS): incidence, pathogenesis and management [Internet] Expert Opin Drug Saf. 2016:1-9. Go to original source... Go to PubMed...
    5. Muller P, Dubreil P, Mahé A, et al. Drug hypersensitivity syndrom in West Indian polupation. Eur J Dermatol 2003;13:478-481. Go to original source...
    6. Wang L, Mei X-L. Drug reaction with eosinophilia and systemic symptoms: retrospective analysis of 104 cases over one decade. Chin Med J. 2017 Apr 20;130(8):943-949. Go to original source... Go to PubMed...
    7. Chen Y-C, Chiu H-C, Chu C-Y. Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases. Arch Dermatol. 2010 Dec;146(12):1373-1379. Go to original source... Go to PubMed...
    8. Fernando SL. Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome [Internet]. Aust. J. Dermatol. 2014;55:15-23. Go to original source... Go to PubMed...
    9. Corneli HM. DRESS syndrome: drug reaction with eosinophilia and systemic symptoms. Pediatr Emerg Care. 2017 Jul;33(7): 499-502. Go to original source... Go to PubMed...
    10. Cacoub P, Musette P, Descamps V, et al. The DRESS syndrome: a literature review. Am J Med. 2011 Jul;124(7):588-597. Go to original source... Go to PubMed...
    11. Sharifzadeh S, Mohammadpour AH, Tavanaee A, et al. Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. Eur J Clin Pharmacol. 2021 Mar;77(3):275-289. Go to original source... Go to PubMed...
    12. Blumenthal KG, Patil SU, Long AA. The importance of vancomycin in drug rash with eosinophilia and systemic symptoms (dress) syndrome [Internet]. Allergy Asthma Proc. 2012;33:165-171. Go to original source... Go to PubMed...
    13. Kardaun SH, Sekula P, Valeyrie-Allanore L, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013 Nov;169(5):1071-1080. Go to original source... Go to PubMed...
    14. Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, et al. Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro. Eur J Dermatol. 2010 Jan;20(1):68-73. Go to original source... Go to PubMed...
    15. Tomohisa T, Kenta T, Mastoshi S, et al. Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report(Intern Med Advance Publication 2024 April 2 doi:10/2169/internalmedicine.3347-23.
    16. Mallal S, Phillips E, Carosi G, et al. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008 Feb 7;358(6):568-579. Go to original source... Go to PubMed...
    17. Mugwagwa AN, Fischer R, Zailan I. HLA-B*5801: a genetic susceptibility to allopurinol-induced DRESS. Med J Aust. 2016 Mar 7;204(4):159-160. Go to original source... Go to PubMed...
    18. Eshki M, Allanore L, Musette P, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol. 2009 Jan;145(1):67-72. Go to original source... Go to PubMed...
    19. Husain Z, Reddy YB, Schwarz RA. DRESS syndrom: Part I., Clinical Prespective. Jam AcaD Dermatol 2013;68:693.e1-14. Go to original source... Go to PubMed...
    20. Karásek D, Vymětal J, Cibíčková L, et al. Dress syndrom vzniklý při léčbě alopurinolem Klin Farmakol Farm 2014;28(4):152-157.
    21. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. 2007 Mar;156(3):609-611. Go to original source... Go to PubMed...
    22. Creamer D, Walsh SA, Dziewulski P, et al. UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016 (print summary - full guidelines. J Plast Reconstr Aesthetic Surg. 2016 Jun;69(6):736-741. Go to original source... Go to PubMed...
    23. Ortonne N, Valeyrie-Allanore L, Bastuji-Garin S, et al. Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. Br J Dermatol. 2015 Jul;173(1):50-58. Go to original source... Go to PubMed...
    24. Jurado-Palomo J, Cabañas R, Prior N, et. al. Use of the lymphocyte transormation test in the diagnosis of DRESS syndrome induced by ceftriaxone and piperacillin-tazobactam: two cace reports. J Inestig Allergol Clin Immunol, 2010;20(5):433-6.
    25. Descamps V, Ben Saïd B, Sassolas B, et al. Prise en charge du drug reaction with eosinophilia and systemic symptoms (DRESS) [Internet]. Ann Dermatol Vénéréol. 2010;137:703-708. Go to original source... Go to PubMed...
    26. Cabañas R, Ramírez E, Sendagorta E, et al. Spanish guidelines for diagnosis, management, treatment, and prevention of DRESS. Syndrome. J Investig Allergol Clin Immunol. 2020 Jan 14;30(4):229-253. Go to original source... Go to PubMed...
    27. Ganeva M, Gancheva T, Lazarova R, et al. A Prospective Study of Adverse Drug Reactions in a Dermatology Department. Methods Find Exp Clin Pharmacol 2007;29(2):107-112. Go to original source... Go to PubMed...
    28. Mičaníková H. Přehled polékových exantémů. Med. praxi. 2017;14(1):39-44. Go to original source...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.