Vnitr Lek 2024, 70(4):260-263
News in geriatric medicine - what's new in dementia?
- Všeobecná interní klinika, Fakultní nemocnice Brno
- Lékařská fakulta Masarykovy univerzity, Brno
Population aging is changing the world dramatically and fundamentally. Contemporary geriatrics has an interventional and preventive nature and strives to preserve physical and mental health for as long as possible, prevent loss of self-sufficiency and improve the prognosis of seniors with a focus on quality of life. Dementia is a serious problem that geriatrics deals with. The diagnosis of dementia not only affects the quality of life of individuals, but also represents a huge social and economic burden for the family, health systems and society. With the aging of the population, dementia has become an important problem in our health care and there is an urgent need to find an effective treatment.
Keywords: dementia, geriatric medicine, lecanemab, donanemab, folic acid, phototherapy.
Accepted: June 5, 2024; Published: June 20, 2024 Show citation
References
- World Health Organization. Dementia fact sheet. 2023. Availabler from: https://www.who.int/news-room/fact-sheets/detail/dementia
- Vaňková H, Hrnčiariková D, Závadová I, et al. Mezioborová klinická doporučení pro diagnostiku a léčbu Alzheimerovy nemoci: "Bílá kniha paliativní péče" v aktuálním kontextu. Geri a gero. 2024;(1):47-51.
- Doporučené diagnostické a terapeutické postupy pro všeobecné praktické lékaře. Demence Novelizace 2024. Availabler from: http://svl.cz/doporucene-postupy/demence-100017
- Kleinová L, Cerman J, Hlávka J, et al. Nové farmakologické možnosti v léčbě Alzheimerovy nemoci. Cesk Slov Neurol N. 2022;85(6):462-469.
Go to original source...
- Hoy SM. Lecanemab: First approval. Drugs. 2023;83(4):359-365. doi: 10.1007/s40265-023-01851-2.
Go to original source...
Go to PubMed...
- Nelson S, Lopez O. Lecanemab for Alzheimer disease. Neurology. 2024; 102 (7). e209265. doi: 10.1212/WNL.0000000000209265.
Go to original source...
Go to PubMed...
- Lapka M. Lecanemab. Remedia. 2023;33:73-76.
Go to original source...
- Eisai global. New release. March 22, 2024. Availabler from: https://www.eisai.com/news/2024/news202417.html
- van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in Early Alzheimer's Disease. N Engl J Med. 2023;388(1):9-21. doi: 10.1056/NEJMoa2212948.
Go to original source...
Go to PubMed...
- Gueorguieva I, Willis BA, Chua L, et al. Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease. Clin Pharmacol Ther. 2023; 113(6):1258-1267. doi: 10.1002/cpt.2875.
Go to original source...
Go to PubMed...
- Lo A C, Duggan EC, Wessels AM, et al. Donanemab in early Alzheimer's disease. N Engl J Med. 2021;384(18):1691-1704.
Go to original source...
Go to PubMed...
- The New York Times. March 8,2024. Availabler from: https://www.nytimes.com/2024/03/08/health/alzheimers-drug-donanemab.html
- Qiao Y, Gu J, Yu M, et al. Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer's Disease: A Systematic Review and Network Meta-Analysis. CNS Drugs. 2024 Mar;38(3):169-192. doi: 10.1007/s40263-024-01067-2.
Go to original source...
Go to PubMed...
- Ross EL, Weinberg MS, Arnold SE. Cost-effectiveness of aducanumab and donanemab for early Alzheimer disease in the US. JAMA Neurol. 2022;79(5):478-487. doi: 10.1001/jamaneurol.2022.0315.
Go to original source...
Go to PubMed...
- Nguyen HV, Mital S, Knopman DS, Alexander GC. Cost-effectiveness of lecanemab for individuals with early-stage Alzheimer disease. Neurology. 2024;102:e209218. doi: 10.1212/WNL.0000000000209218.
Go to original source...
Go to PubMed...
- Lu X, Liu C, Shao F. Phototherapy improves cognitive function in dementia: A systematic review and meta-analysis. Brain Behav. 2023 May;13(5):e2952. doi: 10.1002/brb3.2952.
Go to original source...
Go to PubMed...
- Creavin ST, Wisniewski S, Noel-Storr AH, et al. Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016 Jan 13;2016(1):CD011145. doi: 10.1002/14651858.CD011145.
Go to original source...
- Tao T, Feng G, Fang Y. Association between aspirin use and risk of dementia: a systematic review and meta-analysis. Eur Geriatr Med. 2024;15(1):3-18. doi: 10.1007/s41999-023-00877-9.
Go to original source...
Go to PubMed...
- Xu M, Zhu Y, Chen J et al. Effects of folic acid supplementation on cognitive impairment: A meta-analysis of randomized controlled trials. J Evid Based Med. 2024;17(1):134-144. doi: 10.1111/jebm.12588.
Go to original source...
Go to PubMed...
- Akhgarjand C, Vahabi Z, Shab-Bidar S, et al. The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Inflammopharmacology. 2024;32(2):1413-1420. doi: 10.1007/s10787-023-01427-2.
Go to original source...
Go to PubMed...