Vnitr Lek 2024, 70(4):241-244
Multiple myeloma as a cause of primary graft dysfunction after kidney transplantation
- 1 Klinika nefrologie, Institut klinické a experimentální medicíny, Praha
- 2 Pracoviště klinické a transplantační patologie, Institut klinické a experimentální medicíny, Praha
Low incidence of multiple myeloma (MM) in the general population is one of the reasons for absence of a screening program. Kidney dysfunction is one of the most common types of end-organ damage in MM patients. Some transplant centers, therefore, established a screening to detect monoclonal immunoglobulin, mostly employing serum protein electrophoresis (SPEP) with or without immunofixation of serum and urine. If only monoclonal free light chain is produced, however, the sensitivity of SPEP and immunofixation is low. Here, we describe a case report of patient with newly diagnosed MM only after kidney transplantation. This case report emphasis the need for screening of monoclonal gammopathy (MG) in patients whose cause of kidney failure is unknown.
Keywords: chronic kidney disease, multiple myeloma, kidney transplantation, protein electrophoresis, free light chains.
Accepted: June 5, 2024; Published: June 20, 2024 Show citation
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