Vnitr Lek 2023, 69(5):E15-E19 | DOI: 10.36290/vnl.2023.066

Selected biomarkers of orthostatic intolerance

Barbora Bačkorová, Ivica Lazúrová
1. interná klinika UNLP a UPJŠ LF Košice

Orthostatic intolerance (OI) is defined as a group of diseases which symptoms are typically manifested in a standing position. These symptoms result from cerebral hypoperfusion and disappear in the supine position. We include postural orthostatic intolerance syndrome (POTS), orthostatic hypotension (OH) and vasovagal orthostatic syncope in this group of diseases. Each of them have similar clinical presentation (blurred vision, weakness, dizziness, nausea, headaches, fatigue). However, they vary from each other in biochemical, autonomic and hemodynamic characteristics. The aim of the work is to provide an overview of humoral and non-human markers that are involved in the etiopathogenesis of orthostatic intolerance.

Keywords: biomarkers, orthostatic intolerance, POTS, vasovagal syncope.

Accepted: September 4, 2023; Published: September 12, 2023  Show citation

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Bačkorová B, Lazúrová I. Selected biomarkers of orthostatic intolerance. Vnitr Lek. 2023;69(5):E15-19. doi: 10.36290/vnl.2023.066.
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    References

    1. Gilmore S, Hart J, Geddes J, et al. Classification of orthostatic intolerance through data analytics. Med Biol Eng Comput. 2021;59(3):621-632. Go to original source... Go to PubMed...
    2. Freitas J, Azevedo E, Santos R, et al. Autonomic activity and biomarker behavior in supine position and after passive postural stress in different orthostatic intolerance syndromes. Rev Port Cardiol. 2015;34(9):543-9. Go to original source... Go to PubMed...
    3. van Dijk JG, van Rossum IA, Thijs RD. The pathophysiology of vasovagal syncope: Novel insights. Auton Neurosci. 2021;236:102899. Go to original source... Go to PubMed...
    4. Medic Spahic J, Ricci F, Aung N, et al. Proteomic analysis reveals sex­‑specific biomarker signature in postural orthostatic tachycardia syndrome. BMC Cardiovasc Disord. 2020;20(1):190. Go to original source... Go to PubMed...
    5. Frith J, Parry SW. New Horizons in orthostatic hypotension. Age Ageing. 2017;46(2):168-174. Go to original source... Go to PubMed...
    6. Jones PK, Shaw BH, Raj SR. Orthostatic hypotension: managing a difficult problem. Expert Rev Cardiovasc Ther. 2015;13(11):1263-76. Go to original source... Go to PubMed...
    7. Lei LY, Chew DS, Raj SR. Differential diagnosis of orthostatic hypotension. Auton Neurosci. 2020;228:102713. Go to original source... Go to PubMed...
    8. Wieling W, Kaufmann H, Claydon VE, et al. Diagnosis and treatment of orthostatic hypotension. Lancet Neurol. 2022;21(8):735-746. Go to original source... Go to PubMed...
    9. Fedorowski A, Ricci F, Sutton R. Orthostatic hypotension and cardiovascular risk. Kardiol Pol. 2019;77(11):1020-1027. Go to original source... Go to PubMed...
    10. Krishnan B, Benditt DG. Neuropeptides and peptide hormones in syncope and orthostatic intolerance. Cardiol J. 2014;21(6):591-600. Go to original source... Go to PubMed...
    11. Veazie S, Peterson K, Ansari Y, et al. Fludrocortisone for orthostatic hypotension. Cochrane Database Syst Rev. 2021;5(5):CD012868. Go to original source... Go to PubMed...
    12. Pektas A, Koken R, Koca HB. Serum vitamin B-12 in children presenting with vasovagal syncope. Asia Pac J Clin Nutr. 2018;27(1):176-181.
    13. Zhao J, Du S, Yang J, et al. Usefulness of plasma copeptin as a biomarker to predict the therapeutic effectiveness of metoprolol for postural tachycardia syndrome in children. Am J Cardiol. 2014;114(4):601-5. Go to original source... Go to PubMed...
    14. Lazurová Z, Čabrová M., Mitro P. Syndróm posturálnej ortostatickej tachykardie. Interná med. 2022; 22 (12):508-512.
    15. Benditt DG, van Dijk JG, Krishnappa D, et al. Neurohormones in the Pathophysiology of Vasovagal Syncope in Adults. Front. Cardiovasc. Med. 2020;7:76. Go to original source... Go to PubMed...
    16. Barbot, M., Ceccato, F., Zilio, M. et al. Cardiovascular autonomic dysfunction in patients with idiopathic diabetes insipidus. Pituitary. 2018; 21, 50-55. Go to original source... Go to PubMed...
    17. Zhang F, Li X, Ochs T, et al. Midregional pro­‑adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome. J Am Coll Cardiol. 2012;60(4):315-20. Go to original source... Go to PubMed...
    18. Plasek J, Doupal V, Furstova J, et al. The role of adrenomedullin and galanin in recurrent vasovagal syncope: a case control study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013;157(2):162-7. Go to original source... Go to PubMed...
    19. Bai W, Han Z, Chen S, et al. Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children. Pediatr Cardiol. 2017;38(8):1639-1644. Go to original source... Go to PubMed...
    20. Mar, PL and Raj, SR. Neuronal and hormonal perturbations in postural tachycardia syndrome. Front. Physiol. 2014;5:220. Go to original source... Go to PubMed...
    21. Zhao J, Yang J, Du S, et al. Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study. Chin Med J (Engl). 2014;127(10):1853-7. Go to original source... Go to PubMed...
    22. Stryjewski PJ, Nessler B, Kuczaj A, et al. The role of NT­‑proBNP in the diagnostics and differentiation of cardiac and reflex syncope in adults: relative importance to clinical presentation and medical examinations. J Interv Card Electrophysiol. 2014;41(1):1-8. Go to original source... Go to PubMed...
    23. Lin J, Han Z, Li H, et al. Plasma C­‑Type Natriuretic Peptide as a Predictor for Therapeutic Response to Metoprolol in Children with Postural Tachycardia Syndrome. PLoS ONE. 2015; 10(3): e0121913. Go to original source... Go to PubMed...
    24. Raziq H, Fayyaz H, Azhar R, et al. Association of serotonin levels in patients of vasovagal syncope and postural tachycardia syndrome. J Pak Med Assoc. 2021;71(8):1963-1966. Go to PubMed...
    25. Khan HF, Ambreen S, Raziq H, et al. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):185-189. Go to original source... Go to PubMed...
    26. Johansson M, Ricci F, Schulte J, et al. Circulating levels of growth hormone in postural orthostatic tachycardia syndrome. Sci Rep. 2021;11(1):8575. Go to original source... Go to PubMed...
    27. Annweiler C, Schott AM, Rolland Y, et al. Vitamin D deficiency is associated with orthostatic hypotension in oldest­‑old women. J Intern Med.;276(3):285-295. Go to original source... Go to PubMed...
    28. Duval GT, Paré PY, Gautier J, et al. Vitamin D and the Mechanisms, Circumstances and Consequences of Falls in Older Adults: A Case­‑Control Study. J Nutr Health Aging. 2017;21(10):1307-1313. Go to original source... Go to PubMed...
    29. Brignole M, Rivasi G. New insights in diagnostics and therapies in syncope: a novel approach to non­‑cardiac syncope. Heart. 2021;107(11):864-873. Go to original source... Go to PubMed...
    30. Brignole M, Groppelli A, Brambilla R, et al. Plasma adenosine and neurally mediated syncope: ready for clinical use. Europace. 2020;22(6):847-853. Go to original source... Go to PubMed...
    31. Stickford AS, VanGundy TB, Levine BD, et al. Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome. J Physiol. 2015;593(9):2131-43. Go to original source... Go to PubMed...
    32. Prado M, Fiorelli EM, Tobaldini E, et al. An unusual syncope. Intern Emerg Med. 2013;8(1):65-7. Go to original source... Go to PubMed...
    33. Brignole M., Moya A., de Lange F. et al. 2018 ESC Guidelines for the diagnosis and management of syncope, European Heart Journal, 2018, 39, 21, 1883-1948. Go to original source... Go to PubMed...

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