Vnitr Lek 2023, 69(3):156-165 | DOI: 10.36290/vnl.2023.028

Multimorbidity in nephrotic syndrome

Vladimír Teplan^{1, 2}

¹ Interní a kardiologická klinika Fakultní nemocnice Ostrava a Lékařská fakulta Ostravské univerzity, Ostrava

² Subkatedra nefrologie, Institut postgraduálního vzdělávání ve zdravotnictví, Praha

Nephrotic syndrome (NS) is characterized by high proteinuria (over 3,5g/24 hrs), hypalbuminaemia, general edemas and hypercoagulation. Beside of primary glomerulonephritides this is found in secundary glomerulopaties eg. diabetes, systemic inflammatory diseases, oncology, damage by drugs and poisoning, by alergy, serious infections and in children from hereditary reasons. The most frequent reason for NS in adults patiens is diabetes and diabetes with nephropathy represents almost 40% of dialysed patiens. From this point of view, there is great interest focusing on gliflozins (SGLT2 inhibitors) with positive nephroprotecive effect. It leads do increasing of glycosuria with concomitant natriuresis and osmotic diuresis. The effect is proportional to glomerulal filtration, but the effect on natriuresis stay in all stages of renal insufficiency.

Keywords: nephrotic syndrome, primary and secundary glomeruolopaties, diabetes, gliflozins.

Accepted: April 27, 2023; Published: May 16, 2023  Show citation