Vnitr Lek 2023, 69(2):E23-E25 | DOI: 10.36290/vnl.2023.025

Role of eplerenone in the threatment of cardiovascular diseases

Filip Málek
Kardiovaskulární centrum, Nemocnice Na Homolce, Praha

Eplerenone is a selective mineralocorticoid receptor antagonist. Its approved for the therapy of patients with chronic heart failure with left ventricular systolic dysfunction and for the patients after myocardial infarction complicated by heart failure and left ventricular dysfunction. It´s also recommended for the therapy of primary hyperaldosteronism and the treatment of drug resistant hypertension.

Keywords: eplerenone, mineralocorticoid receptors, heart failure, hyperaldosteronism, resistant hypertension.

Accepted: March 29, 2023; Published: March 30, 2023  Show citation

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Málek F. Role of eplerenone in the threatment of cardiovascular diseases. Vnitr Lek. 2023;69(2):E23-25. doi: 10.36290/vnl.2023.025.
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References

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  2. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2022;24:4-131. Go to original source...
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  9. SPC Eplerenon. Available from: file:///C:/Users/11366/Downloads/eplerenon‑sandoz‑spc%20(1).pdf.Riziko úmrtí-15 %, p = 0,008Riziko úmrtí a hospitalizace z KV příčin-13 %, p = 0,002Riziko náhlé srdeční smrti-21 %, p = 0,03




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