Vnitr Lek 2023, 69(2):E19-E22 | DOI: 10.36290/vnl.2023.024

Severe autoimune thyreotoxicosis complicated by febrile neutropenia as a result of thyreostatic therapy

Marie Jarolímová, Michal Kazmíř
Interní oddělení, Oblastní nemocnice Kolín, a. s.

Hyperthyreoidism is a clinical manifestation of excessive production of thyroid hormones. In most cases pacient´s condition allows ambulant treatment. Rarely, it can develop into an acute, life- threatening thyrotoxic crisis which has to be treated in the intensive care unit. Main therapy includes antithyroid medication, corticosteroids, beta-blockers and rehydratation, mostly parenteral. If initial treatment fails, plasmapheresis provides effective strategy. Antithyroid medication may come with side effects as rash, digestive issues, joint pain.Agranulocystosis or acute liver lesion which leads to liver failure belong among the most severe ones. In this case we report a pacient with thyrotoxic crisis, atrial fibrilation which led to ventricular fibrilation, cor thyreotoxicum. The treatment was complicated by febrile neutropenia.

Keywords: agranulocytosis, hyperthyreoidism, Lugol solution, total thyreoidectomy, thyrotoxic crisis.

Accepted: March 29, 2023; Published: March 30, 2023  Show citation

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Jarolímová M, Kazmíř M. Severe autoimune thyreotoxicosis complicated by febrile neutropenia as a result of thyreostatic therapy. Vnitr Lek. 2023;69(2):E19-22. doi: 10.36290/vnl.2023.024.
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