Vnitr Lek 2023, 69(2):E10-E18 | DOI: 10.36290/vnl.2023.023

Anemia of inflammatory: does eiderr knowledge mean better diagnosis and treatment?

Jaromír Tupý

Klinika hematológie a transfuziológie, ÚVN SNP Ružomberok - FN

Fakulta zdravotníctva, katolícka univerzita v Ružomberku

Anemia, which is a manifestation of the deterioration of patients' health and performance, is a common concomitant condition in diseases with signs of inflammation activation. This anemia - anemia of inflammation, is caused by disturbances of iron metabolism that lead to iron retention within macrophages, cytokine mediated inhibition of erythropoietin function and erythroid progenitor cell differentiation, and a reduced erytrocyte half-life. Anemia is usually mild to moderate, normocytic and normochromic. It is characterized by low iron circulation, but normal to increased levels of stored ferritin and the hormone hepcidin. The primary therapeutic approach is the treatment of the underlying inflammatory disease. In case of failure, iron supplementation and / or treatment with erythropoietin stimulating agents may be used. Blood transfusions are just an emergency treatment for life-threatening anemia. A new treatment modalities with hepcidin-modifying strategies and stabilizers of hypoxia inducible factors is emerging. However, their therapeutic efficacy needs to be verified and evaluated in clinical trials.

Keywords: anemia of inflammatory, iron homeostasis, hepcidin, diagnosis, treatment.

Accepted: March 29, 2023; Published: March 30, 2023  Show citation