Vnitr Lek 2022, 68(4):240-245 | DOI: 10.36290/vnl.2022.050

Acetylsalicylic acid in primary prevention of cardiovascular disease

Roman Miklík1, 2, 3, Otakar Jiravský3
1 Interní oddělení, Vojenská nemocnice Brno
2 Kardiologická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Karlovy v Plzni, Plzeň
3 Nemocnice Agel Třinec‑Podlesí, Třinec

Acetylsalicylic acid is an effective and widely accepted essential drug in the secondary prevention of ischemic events. Its role in primary prevention has been studied for several decades and still remains controversial. Initial studies showed a reduction in both myocardial infarctions and ischemic strokes, without affecting overall or cardiovascular mortality, but the enrolled subjects were not treated with modern drugs and procedures in primary preventive care as they do today. Recently published studies have also not shown a mortality benefit, but in some sub-populations and groups of patients, the clinical benefit of aspirin continues to outweigh the risks associated with its long-term use. This review article will discuss the development of ASA in primary prevention, the results of the latest studies of the year 2018 and their meta-analyses, current indications for ASA treatment, as well as future perspectives.

Keywords: aspirin, clinical benefit, ischemic risk, primary prevention, risk of bleeding.

Published: June 22, 2022  Show citation

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Miklík R, Jiravský O. Acetylsalicylic acid in primary prevention of cardiovascular disease. Vnitr Lek. 2022;68(4):240-245. doi: 10.36290/vnl.2022.050.
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