Vnitr Lek 2021, 67(Suppl.B):5-8 | DOI: 10.36290/vnl.2021.066

Vitamin B12 p. o. v teorii i praxi

MUDr. Zuzana Zafarová

Na 16. konferenci Interní medicína pro praxi, která se uskutečnila 2021 on-line, byl jeden z bloků věnován vitaminu B12. Oba přednášející profesoři - prof. MUDr. Richard Češka, CSc., a prof. MUDr. Milan Kvapil, CSc., MBA - překvapili u tohoto tématu některými novými poznatky a především ukázali, že díky pasivní absorpci vitaminu B12 v tenkém střevě při perorálním podávání jeho vysokých dávek je možné dosáhnout cílové hladiny tohoto vitaminu v krvi a pacienty s deficiencí není nutné trápit opakovanou aplikací intramuskulárních injekcí. Popsali skupiny osob ohrožené deficitem vitaminu B12, jako jsou starší jedinci, vegani či pacienti léčení aminosalicyláty, inhibitory protonové pumpy či metforminem. Prezentovali také 2 kazuistiky, které dokládají využití vitaminu B12 gamma u pacientů s makrocytární anémií.

Published: July 15, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Zafarová Z. Vitamin B12 p. o. v teorii i praxi. Vnitr Lek. 2021;67(Suppl. B - Zaznělo na):5-8. doi: 10.36290/vnl.2021.066.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blicklé JF. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004; 171(3): 251-259. Go to original source... Go to PubMed...
    2. Herbert V. Staging vitamin B-12 (cobalamin) status in vegetarians. Am J Clin Nutr. 1994; 59(5 Suppl): 1213S-1222S. Go to original source... Go to PubMed...
    3. Pawlak R, Parrott SJ, Raj S, Cullum-Dugan D, Lucus D. How prevalent is vitamin B(12) deficiency among vegetarians? Nutr Rev. 2013; 71(2): 110-117. Go to original source... Go to PubMed...
    4. Ekabe CJ, Kehbila J, Abanda MH, Kadia BM, Sama CB, Monekosso GL. Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case report. BMC Res Notes. 2017; 10(1): 72. Go to original source... Go to PubMed...
    5. Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults. QJM. 2009; 102(1): 17-28. Go to original source... Go to PubMed...
    6. Wong CW. Vitamin B12 deficiency in the elderly: is it worth screening? Hong Kong Med J. 2015; 21(2): 155-164. Go to original source... Go to PubMed...
    7. John S, Hoegerl C. Nutritional deficiencies after gastric bypass surgery. J Am Osteopath Assoc. 2009; 109(11): 601-604. Go to PubMed...
    8. Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013; 310(22): 2435-2442. Go to original source... Go to PubMed...
    9. Rozgony NR, Fang C, Kuczmarski MF, Bob H. Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors in institutionalized older adults: could a cyanocobalamin nasal spray be beneficial? J Nutr Elder. 2010; 29(1): 87-99. Go to original source... Go to PubMed...
    10. Ko SH, Ko SH, Ahn YB, Song KH, Han KD, Park YM, Ko SH, Kim HS. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J Korean Med Sci. 2014; 29(7): 965-972.
    11. Berlin H, Berlin R, Brante G. Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor. Acta Med Scand. 1968; 184(4): 247-258. Go to original source... Go to PubMed...
    12. Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, van Staveren WA. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med. 2005; 165(10): 1167-1172. Go to original source... Go to PubMed...
    13. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther. 2003; 25(12): 3124-3134. Go to original source... Go to PubMed...
    14. Castelli MC, Friedman K, Sherry J, Brazzillo K, Genoble L, Bhargava P, Riley MG. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011; 33(3): 358-371.e2. Go to original source... Go to PubMed...
    15. SPC vitamin B12 gamma. www.sukl.cz
    16. Chan CQ, Low LL, Lee KH. Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia. Front Med (Lausanne). 2016; 3: 38. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.