Vnitr Lek 2021, 67(8):455-458 | DOI: 10.36290/vnl.2021.119

Acute searching and early diagnosis of HCV infected persons

Petr Husa ml., Petr Husa
Klinika infekčních chorob Lékařské fakulty MU Brno a FN Brno

Hepatitis C virus (HCV) infection is still a major cause of chronic liver diseases, with approximately 71 million chronically infected persons worldwide. People who inject drugs currently or in the past (PWID), mostly intravenously, are the main risk group among HCV chronically infected persons. The efficacy of therapy with direct-acting antivirals (DAA) is almost 100 %. Currently, the main mission is to diagnose HCV infection in the most possible number of infected persons; it is in collision with poor adherence of PWID in particular. Changing the spectrum of chronic hepatitis C patients forces medical professionals to change their approach to diagnosis and treatment of HCV infection. Outreach testing and cooperation with support organizations showed to be an effective way to set a course to eliminate HCV in the PWID population.

Keywords: : chronic hepatitis C, HCV elimination, outreach screening.

Published: December 9, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Husa P, Husa P. Acute searching and early diagnosis of HCV infected persons. Vnitr Lek. 2021;67(8):455-458. doi: 10.36290/vnl.2021.119.
Download citation

References

  1. EASL recommendations on treatment of hepatitis C: final update of the series. CPG HCV. J Hepatol 2020; https://doi.org/10.1016/j.jhep.2020. 08. 018. Go to original source...
  2. World Health Organization. Guidelines for the screening, care and treatment of persons with chronic hepatitis C infection. Updated version 2019. Dostupné na: https://www.who.int/news‑room/fact‑sheets/detail/hepatitis‑c.
  3. Selvapatt N, Ward T, Harrison L, Lombardini J, Thursz M, McEwan P, Brown A. The cost impact of outreach testing and treatment for hepatitis C in an urban Drug Treatment Unit. Liver Int Off J Int Assoc Study Liver. 2017 Mar; 37 (3):345-353. PMID: 27566283 Go to original source... Go to PubMed...
  4. Kim H, Guerrero R, Reader SW, Daheri M, Balakrishnan M, Troisi CL, El‑Serag HB, Thrift AP. Low Yield of Hepatitis C Infection in an Outreach Screening Program in Harris County, Texas. Open Forum Infect Dis [Internet]. 2020 Jul 1 [cited 2021 Jan 31]; 7(ofaa191). Available from: https://doi.org/10.1093/ofid/ofaa191 Go to original source... Go to PubMed...
  5. Husa P ml, Husa P. Význam terénního testování v eliminaci hepatitidy C. Klin mikrobiol inf lék 2021; 27 (1): 13-17.
  6. Acero Fernández D, Ferri Iglesias MJ, Buxó Pujolràs M, López Nuñez C, Serra Matamala I, Queralt Molés X, Aldeguer Manté X. Changes in the epidemiology and distribution of the hepatitis C virus genotypes in North‑Eastern Spain over the last 35 years. Gastroenterol Hepatol. Elsevier; 2018 Jan 1; 41(1): 2-11. Go to original source... Go to PubMed...
  7. Krekulová L, Řehák V, Strunecký O, Nĕmeček V. Current Situation and Trends in the Hepatitis C Virus Genotype Distribution among Injecting Drug Users in the Czech Republic. Epidemiol Mikrobiol Imunol 2009; 58 (1): 84-89.
  8. Kim H, Guerrero R, Reader SW, Daheri M, Balakrishnan M, Troisi CL, El‑Serag HB, Thrift AP. Low Yield of Hepatitis C Infection in an Outreach Screening Program in Harris County, Texas. Open Forum Infect Dis [Internet]. 2020 Jul 1 [cited 2021 Jan 31]; 7(ofaa191). Available from: https://doi.org/10.1093/ofid/ofaa191 Go to original source... Go to PubMed...
  9. Hůlek P, Urbánek P, et al. Hepatologie: 3. vydání 2018. Praha: Grada Publishing, a. s.; 2018.
  10. Minola E, Prati D, Suter F, Maggiolo F, Caprioli F, Sonzogni A, Fraquelli M, Paggi S, Conte D. Age at infection affects the long‑term outcome of transfusion‑associated chronic hepatitis C. Blood. 2002 Jun 15; 99(12): 4588-4591. PMID: 12036892 Go to original source... Go to PubMed...
  11. de Oliveira AC, Bortotti AC, Nunes NN, El Bacha IAH, Parise ER. Association between age at diagnosis and degree of liver injury in hepatitis C. Braz J Infect, DiS. 2014 Sep 1; 18(5): 507-511.
  12. Pawlotsky J‑M, Negro F, Aghemo A, Berenguer M, Dalgard O, Dusheiko G, Marra F, Puoti M, Wedemeyer H. EASL recommendations on treatment of hepatitis C: Final update of the series. J Hepatol. 2020 Nov 1; 73(5): 1170-1218. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.