Vnitr Lek 2021, 67(7):404-410 | DOI: 10.36290/vnl.2021.108

Expert consensus on the practical aspects of the cooperation of cardiologist and diabetologist in the management of the patients with chronic heart failure and reduced ejection fraction

Martin Haluzík¹, Markéta Kubíčková², Jiří Veselý^{2, 3}, Aleš Linhart⁴, Martin Prázný⁵, Jan Škrha⁵, Miloš Táborský⁶, Filip Málek^{7, 8}

¹ Centrum diabetologie IKEM, Praha

² III. interní gerontometabolická klinika, Fakultní nemocnice Hradec Králové a Univerzita Karlova - Lékařská fakulta v Hradci Králové

³ EDUMED, s. r. o., Náchod

⁴ II. interní klinika Všeobecné fakultní nemocnice a 1. lékařské fakulty Univerzity Karlovy v Praze

⁵ III. interní klinika Všeobecné fakultní nemocnice a 1. lékařské fakulty Univerzity Karlovy v Praze

⁶ I. interní kardiologická klinika Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého, Olomouc

⁷ Kardiologické oddělení Nemocnice na Homolce, Praha

⁸ Interní klinika Fakultní nemocnice Královské Vinohrady a 3. lékařské fakulty Univerzity Karlovy v Praze

Diabetes mellitus is an important risk factor for the development of heart failure and presence of diabetes significantly worsens heart failure outcome. Introduction of gliflozins to the therapy of heart failure is one of the most important novelty. Gliflozins reduce glucose level by the sodium-glucose contransporter 2 inhibition in proximal tubulus in the kidney. Gliflozins are used as effective antidiabetic drugs with improvement of glycemic control without risk of hypoglycemia, gliflozins decrease blood pressure and patients weight. Recent studies have shown that gliflozins significantly reduce risk of cardiovascular complications and heart failure hospitalizations in diabetic patients. Clinical trials with dapagliflozin and empagliflozin have shown reduction of the risk of cardiovascular death and heart failure hospitalization in the patients with heart failure and reduced ejection fraction both in the patients with diabetes and in the patients without diabetes. The aim of the expert consenzus is to summarize practical aspects in the cooperation of cardiologist and diabetologist in the management of the patients with heart failure and reduced ejection fraction in the context of the current guidelines and other treatment options.

Keywords: heart failure with reduce ejection fraction, gliflozins, cardiovascular complications, type 2 diabetes mellitus.

Published: November 1, 2021  Show citation