Vnitr Lek 2021, 67(6):334-338 | DOI: 10.36290/vnl.2021.089

Anti-cancer therapy-induced metabolic syndrome

Eva Řiháčková1, Lubomír Elbl1, Michal Řiháček2, Mária Holická1, Petr Kala1
1 Interní kardiologická klinika, LF MU a FN Brno
2 Biochemický ústav, LF MU, Brno

The increasing number of long-term survivors that underwent the anti-cancer therapy faces the late treatment-related adverse effects and the increased risk of developing metabolic syndrome. This article defines the pathophysiology that underlies development of anti-cancer therapy-related metabolic syndrome and outlines the possibility of optimisation of comprehensive care focusing on prevention. Considering the preventability of metabolic syndrome, effective screening and follow-up appropriate for patients at increased risk of related adverse events should be established. Subsequently, early initiation of therapy targeting the hallmarks of metabolic syndrome may ease its manifestation in long-term perspective.

Keywords: oncology, metabolic syndrome, anti-cancer therapy.

Published: October 13, 2021  Show citation

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Řiháčková E, Elbl L, Řiháček M, Holická M, Kala P. Anti-cancer therapy-induced metabolic syndrome. Vnitr Lek. 2021;67(6):334-338. doi: 10.36290/vnl.2021.089.
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    References

    1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988; 37(12): 1595-607. Go to original source... Go to PubMed...
    2. Parikh RM, Mohan V. Changing definitions of metabolic syndrome. Indian J Endocrinol Metab. 2012; 16(1): 7-12. Go to original source... Go to PubMed...
    3. Tellechea ML, Aranguren F, Martínez-Larrad MT et al. Ability of lipid accumulation product to identify metabolic syndrome in healthy men from Buenos Aires. Diabetes Care. 2009; 32(7): e85. Go to original source... Go to PubMed...
    4. Alberti KG, Eckel RH, Grundy SM et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16): 1640-5. Go to original source... Go to PubMed...
    5. Grundy SM, Cleeman JI, Daniels SR et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112(17): 2735-52. Go to original source...
    6. Lau DC, Dhillon B, Yan H et al. Adipokines: molecular links between obesity and atheroslcerosis. Am J Physiol Heart Circ Physiol. 2005; 288(5): H2031-41. Go to original source... Go to PubMed...
    7. Cinti S, Mitchell G, Barbatelli G et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46(11): 2347-55. Go to original source... Go to PubMed...
    8. Bernberg E, Ulleryd MA, Johansson ME et al. Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE-/ - mice. Atherosclerosis. 2012; 221(2): 359-65. Go to original source... Go to PubMed...
    9. Azzawi M, Hasleton P. Tumour necrosis factor alpha and the cardiovascular system: its role in cardiac allograft rejection and heart disease. Cardiovasc Res. 1999; 43(4): 850-9. Go to original source... Go to PubMed...
    10. Ryo M, Nakamura T, Kihara S et al. Adiponectin as a biomarker of the metabolic syndrome. Circ J. 2004; 68(11): 975-81. Go to original source... Go to PubMed...
    11. Matsuzawa Y, Funahashi T, Kihara S, et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004; 24(1): 29-33. Go to original source... Go to PubMed...
    12. Combs TP, Berg AH, Obici S et al. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest. 2001; 108(12): 1875-81. Go to original source... Go to PubMed...
    13. Maahs DM, Ogden LG, Kinney GL et al. Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation. 2005; 111(6): 747-53. Go to original source... Go to PubMed...
    14. Pischon T, Girman CJ, Hotamisligil GS et al. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004; 291(14): 1730-7. Go to original source... Go to PubMed...
    15. Stocks T, Lukanova A, Johansson M et al. Components of the metabolic syndrome and colorectal cancer risk; a prospective study. Int J Obes (Lond). 2008; 32(2): 304-14. Go to original source... Go to PubMed...
    16. Kabat GC, Kim M, Chlebowski RT et al. A longitudinal study of the metabolic syndrome and risk of postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev. 2009; 18(7): 2046-53. Go to original source... Go to PubMed...
    17. Verdecchia A, Francisci S, Brenner H et al. Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol. 2007; 8(9): 784-96. Go to original source... Go to PubMed...
    18. Phillips SM, Padgett LS, Leisenring WM et al. Survivors of childhood cancer in the United States: prevalence and burden of morbidity. Cancer Epidemiol Biomarkers Prev. 2015; 24(4): 653-63. Go to original source... Go to PubMed...
    19. Pavlík T, Májek O, Büchler T et al. Trends in stage-specific population-based survival of cancer patients in the Czech Republic in the period 2000-2008. Cancer Epidemiol. 2014; 38(1): 28-34. Go to original source... Go to PubMed...
    20. Paris C, Yates L, Lama P et al. Evaluation of metabolic syndrome after hematopoietic stem cell transplantation in children and adolescents. Pediatr Blood Cancer. 2012; 59(2): 306-10. Go to original source... Go to PubMed...
    21. Kim M, Kim IH, Lim MK et al. Increased prevalence of metabolic syndrome in adult cancer survivors: Asian first report in community setting. Cancer Epidemiol. 2019; 58: 130-6. Go to original source... Go to PubMed...
    22. Buttros DeA, Nahas EA, Vespoli HeL et al. Risk of metabolic syndrome in postmenopausal breast cancer survivors. Menopause. 2013; 20(4): 448-54. Go to original source... Go to PubMed...
    23. Kim SH, Cho YU, Kim SJ. Weight Gain and its Correlates among Breast Cancer Survivors. Asian Nurs Res (Korean Soc Nurs Sci). 2013; 7(4): 161-7. Go to original source... Go to PubMed...
    24. Zee P, Chen CH. Prevalence of obesity in children after therapy for acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1986; 8(4): 294-9. Go to original source... Go to PubMed...
    25. Talvensaari KK, Lanning M, Tapanainen P et al. Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J Clin Endocrinol Metab. 1996; 81(8): 3051-5. Go to original source... Go to PubMed...
    26. Gurney JG, Ness KK, Stovall M et al. Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study. J Clin Endocrinol Metab. 2003; 88(10): 4731-9. Go to original source... Go to PubMed...
    27. Oeffinger KC, Mertens AC, Sklar CA et al. Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2003; 21(7): 1359-65. Go to original source... Go to PubMed...
    28. Hoffman KE, Derdak J, Bernstein D et al. Metabolic syndrome traits in long-term survivors of pediatric sarcoma. Pediatr Blood Cancer. 2008; 50(2): 341-6. Go to original source... Go to PubMed...
    29. Haddy TB, Mosher RB, Nunez SB et al. Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Pediatr Blood Cancer. 2006; 46(2): 258-61. Go to original source... Go to PubMed...
    30. Sklar CA, Mertens AC, Walter A et al. Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation. Med Pediatr Oncol. 2000; 35(2): 91-5. Go to original source... Go to PubMed...
    31. Gurney JG, Ness KK, Sibley SD et al. Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer. 2006; 107(6): 1303-1312. Go to original source... Go to PubMed...
    32. Pietilä S, Mäkipernaa A, Sievänen H et al. Obesity and metabolic changes are common in young childhood brain tumor survivors. Pediatr Blood Cancer. 2009; 52(7): 853-9. Go to original source... Go to PubMed...
    33. Link K, Moëll C, Garwicz S, et al. Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. J Clin Endocrinol Metab. 2004; 89(10): 5003-12. Go to original source... Go to PubMed...
    34. Follin C, Thilén U, Ahrén B et al. Improvement in cardiac systolic function and reduced prevalence of metabolic syndrome after two years of growth hormone (GH) treatment in GH-deficient adult survivors of childhood-onset acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2006; 91(5) 1872-5. Go to original source... Go to PubMed...
    35. Meacham LR, Sklar CA, Li S et al. Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the childhood cancer survivor study. Arch Intern Med. 2009; 169(15): 1381-8. Go to original source... Go to PubMed...
    36. van Nimwegen FA, Schaapveld M, Janus CP et al. Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol. 2014;32(29):3257-63. Go to original source... Go to PubMed...
    37. Friedman DN, Hilden P, Moskowitz CS et al. Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study. Pediatr Blood Cancer. 2018; 65(11): e27304. Go to original source... Go to PubMed...
    38. Belle FN, Kasteler R, Schindera C et al. No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment. Cancer. 2018; 124(17): 3576-85. Go to original source... Go to PubMed...
    39. Westerink NL, Nuver J, Lefrandt JD et al. Cancer treatment induced metabolic syndrome: Improving outcome with lifestyle. Crit Rev Oncol Hematol. 2016; 108: 128-36. Go to original source... Go to PubMed...
    40. Casco S, Soto-Vega E. Development of Metabolic Syndrome Associated to Cancer Therapy: Review. Horm Cancer. 2016; 7(5-6): 289-95. Go to original source... Go to PubMed...
    41. Ryder M, Callahan M, Postow MA et al. Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution. Endocr Relat Cancer. 2014; 21(2): 371-81. Go to original source... Go to PubMed...
    42. Bu DX, Tarrio M, Maganto-Garcia E et al. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol. 2011; 31(5): 1100-7. Go to original source... Go to PubMed...
    43. Sklar C, Whitton J, Mertens A et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab. 2000; 85(9): 3227-32. Go to original source...
    44. Sanders JE, Hoffmeister PA, Woolfrey AE et al. Thyroid function following hematopoietic cell transplantation in children: 30 years' experience. Blood. 2009; 113(2): 306-8. Go to original source... Go to PubMed...
    45. Bogefors C, Isaksson S, Bobjer J, et al. Hypogonadism in testicular cancer patients is associated with risk factors of cardiovascular disease and the metabolic syndrome. Andrology. 2017; 5(4): 711-7. Go to original source... Go to PubMed...
    46. Redig AJ, Munshi HG. Care of the cancer survivor: metabolic syndrome after hormone-modifying therapy. Am J Med. 2010; 123(1): 87.e1-6. Go to original source... Go to PubMed...
    47. Sleijfer S. Bleomycin-induced pneumonitis. Chest. 2001;120(2):617-24. Go to original source... Go to PubMed...
    48. de Haas EC, Oosting SF, Lefrandt JD et al. The metabolic syndrome in cancer survivors. Lancet Oncol. 2010; 11(2): 193-203. Go to original source... Go to PubMed...
    49. Cohen P. Metformin for the prevention of androgen deprivation induced metabolic syndrome, obesity and type 2 diabetes. Med Hypotheses. 2009; 72(2): 227-8. Go to original source... Go to PubMed...
    50. Tonorezos ES, Robien K, Eshelman-Kent D et al. Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia. Cancer Causes Control. 2013; 24(2): 313-21. Go to original source... Go to PubMed...
    51. Mostoufi-Moab S, Seidel K, Leisenring WM et al. Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2016; 34(27): 3240-3247. Go to original source... Go to PubMed...

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