Vnitr Lek 2021, 67(3):e11-e14 | DOI: 10.36290/vnl.2021.045

Biomarker GDF-15 in cardiology

Štěpán Havránek, Josef Marek
II. interní klinika - klinika kardiologie a angiologie 1. lékařské fakulty Univerzity Karlovy a Všeobecné fakultní nemocnice v Praze

GDF-15 (Growth differentiation factor 15) is a protein synthesised in some tissues including liver, kidney, heart, or lung. GDF-15 a stress-responsive cytokine. GDF-15 is emerging as a biomarker of cardiometabolic risk and disease burden. GDF-15 is linked to the incidence and prognosis of heart failure. In acute coronary syndromes GDF-15 identifies risk of complications including bleeding, reinfarction, development of heart failure or mortality. In patients with atrial fibrillation, GDF-15 is a potent marker of bleeding adverse events in anticoagulated patients and a predictor of overall mortality. Role of GDF-15 in cardiology is not definitively constituted.

Keywords: GDF-15, biomarker, heart failure, coronary artery disease, atrial fibrillation.

Published: May 26, 2021  Show citation

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Havránek Š, Marek J. Biomarker GDF-15 in cardiology. Vnitr Lek. 2021;67(3):e11-14. doi: 10.36290/vnl.2021.045.
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