Vnitr Lek 2020, 66(6):e46-e52 | DOI: 10.36290/vnl.2020.116

Hospital-acquired methemoglobinemia

Jan Táborský1, Martin Střelka1, Marcela Káňová2, Zdeněk Kořístek3, Šárka Blahutová3, Roman Černohorský1, Tomáš Mičkal1
1 Interní oddělení Nemocnice Nový Jičín, a. s.
2 Klinika anesteziologie, resuscitace a intenzivní medicíny LF OU a FN Ostrava
3 Klinika hematoonkologie LF OU a FN Ostrava

Methemoglobinemia is rare condition of hem iron. Ferrous form iron (Fe2+) is oxidised to Ferric form (Fe3+). Methemoglobin has reduced ability to release oxygen to tissues and thereby leads to tissue hypoxia. We present case of patient with methemoglobinemia of unknown etiology. Methemoglobinemia developed during hospitalization. Diferent causes of methemoglobinemia and also a treatment possibilities are discussed.

Keywords: ascorbic acid, local anesthetic, methemoglobinemia, methylene blue.

Published: October 8, 2020  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Táborský J, Střelka M, Káňová M, Kořístek Z, Blahutová Š, Černohorský R, Mičkal T. Hospital-acquired methemoglobinemia. Vnitr Lek. 2020;66(6):e46-52. doi: 10.36290/vnl.2020.116.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bradberry SM. Occupational methaemoglobinaemia mechanisms of production, features, diagnosis and management including the use of methylene blue. Toxicol Rev 2003; 22: 13-17. Go to original source... Go to PubMed...
    2. Song P, Li X, Yan Y. Analysis of the literature on acute aromatic amino or nitro-compounds poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2014; 32: 366-369. Go to PubMed...
    3. Shatila W, Verma A, Adam S. Plasmapheresis in severe methemoglobinemia following occupational exposure. Transfusion and Apheresis Science 2017; 56: 341-344. Go to original source... Go to PubMed...
    4. Souza do Nascimento T, Otávio Lami Pereira R, Luiz Dias de MelloH, et al. Methemoglobinemia: from diagnosis to treatment. Rev Bras Anestesiol 2008; 58: http://dx.doi.org/10.1590/S0034-70942008000600011 Go to original source... Go to PubMed...
    5. Richard Alyce M, Diaz James H, Kaye AD. Reexamining the Risks of Drinking-Water Nitrates on Public Health. The Ochsner Journal 2015; 14: 392-398.
    6. Gian M, Novaro MD, Herbert D, et al. Benzocaine-induced methemoglobinemia: Experience from a high-volume transesophageal echocardiography laboratory. J Am Soc Echocardiogr 2003; 16: 170-175. Go to original source... Go to PubMed...
    7. Kane GC, Hoehn SM, Behrenbeck TR, et al. Benzocaine-Induced Methemoglobinemia Based on the Mayo Clinic Experience From 28 478 Transesophageal Echocardiograms: Incidence, Outcomes, and Predisposing Factors. Arch Intern Med 2007; 167: 1977-1982. Go to original source... Go to PubMed...
    8. Mutlu M, Erduran E, Aslan Y. Acquired methemoglobinemia in infants. Turk J Haematol 2011; 28: 131-134. Go to original source... Go to PubMed...
    9. Barash M, Reich KA, Rademaker D. Lidocaine-induced methemoglobinemia: a clinical reminder. J Am Osteopath Assoc 2015; 115: 94-98. Go to original source... Go to PubMed...
    10. Ohashi K, Yukioka H, Hayashi M, et al. Elevated methemoglobin in patients with sepsis. Acta Anaesthesiol Scand 1998; 42: 713-716. Go to original source... Go to PubMed...
    11. Carlson DJ, Shapiro FL. Methemoglobinemia from Well Water Nitrates: A Complication of Home Dialysis. Ann Intern Med 1970; 73: 757-759. Go to original source... Go to PubMed...
    12. de Torres JP, Strom JA, Jaber BL, et al. Hemodialysis-associated methemoglobinemia in acute renal failure. Am J Kidney Dis 2002; 39: 1307-1309. Go to original source... Go to PubMed...
    13. Medarov BI, Pahwa S, Reed S, et al. Methemoglobinemia Caused by Portable Dialysis in the Critically. Crit Care Med 2017; 45: e232-e235. Go to original source... Go to PubMed...
    14. Skold A, Cosco DL, Klein R. Methemoglobinemia: pathogenesis, diagnosis, and management. South Med J 2011; 104: 757-761. Go to original source... Go to PubMed...
    15. Sievers RF, Ryon JB. Congenital idiopathic methemoglobinemia: favourable response to ascorbic acis therapy. Arch Intern Med (Chic) 1945; 76: 299-307. doi:10.1001/archinte.1945.00210350045007 Go to original source... Go to PubMed...
    16. Cortazzo JA, Lichtman AD. Methemoglobinemia: a review and recommendations for management. J Cardiothorac Vas Anesth 2014; 28: 1043-1047. Go to original source... Go to PubMed...
    17. Faust AC, Guy E, Baby N. Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. J Emerg Med 2018; 54: 681-684. Go to original source... Go to PubMed...
    18. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med 1999; 34: 646-656. Go to original source... Go to PubMed...
    19. Toker I, Yesilaras M, Tur FC, et al. Methemoglobinemia caused by dapsone overdose: Which treatment is best? Turk J Emerg Med 2016; 15: 182-184. Go to original source... Go to PubMed...
    20. Waller HD, Benöhr HC, Tigges FJ. On the mechanism of ascorbic acid induced methemoglobin reduction of human erythrocytes. Klin Wochenschr 1977; 55: 955-964. Go to original source... Go to PubMed...
    21. Balwani MR, Bawankule CP, Ramteke V, et al. Methylene Blue Induced Methemoglobinemia with Acute Kidney Injury in a Glucose-6-Phosphate Dehydrogenase-deficient Patient. Indian J Nephrol 2017; 27: 465-467. Go to original source... Go to PubMed...
    22. Methylthioninium chloride Proveblue 5 mg/ml solution for injection, SPC, dostupné z https://www.ema.europa.eu
    23. Prchal JT. Clinical Features, Diagnosis, and Treatment of Methemoglobinemia. UpToDate Web site http://www.uptodate.com/contents/clinical-features-diagnosis-and-treatment-of-methemoglobinemia; Accessed 12.02.14
    24. Hoffman RS, Nelson LS, Howland MA (eds.). Goldfrank's Manual of Toxicologic Emergencies. The McGraw-Hill Companies, Inc; 2007: 977-985.
    25. Hunter L, Gordge Ldargan PI, Wood DM. Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: A review. Br J Clin Pharmacol 2011; 72: 18-26. Go to original source... Go to PubMed...
    26. Patnaik S, Natarajan MM, James EJ, et al. Methylene blue unresponsive methemoglobinemia. Indian J Crit Care Med 2014; 18: 253-255. Go to original source... Go to PubMed...
    27. Lockhart V, Ong M. 367 Red Blood Cell Exchange for Treatment of Acquired Methemoglobinemia in a Hospitalized Patient: A Case Report. American Journal of Clinical Pathology 2018; 149: S159-S160. Go to original source...
    28. Khetarpal A, Kotwal U. Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience. Indian J Hematol Blood Transfus 2018; 34: 143-145. Go to original source... Go to PubMed...
    29. Alanazi M. Drugs may be Induced Methemoglobinemia. Journal of Hematology & Thromboembolic Diseases 2017; 10.4172/2329-8790.1000270. Go to original source...
    30. Mark Barash DO, Keith AR, Rademaker D. Lidocaine-Induced Methemoglobinemia: A Clinical Reminder. The Journal of the American Osteopathic Association 2015; 115: 94-98. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.