Vnitr Lek 2019, 65(12):783-787 | DOI: 10.36290/vnl.2019.136

Hypertriglyceridemia and atherosclerosis risk

Rudolf Poledne*, Jan Kovář
Laboratoř pro výzkum aterosklerózy, Centrum experimentální medicíny IKEM, Praha

The history of studying hypertriglyceridemia as a risk factor for atherosclerosis has been going on for a half a century. The significance of this parameter as measured in fasting state is not entirely clear, since the statistical significance between triglyceride concentration and cardiovascular risk is lost after adjustment to HDL-cholesterol concentration. Remnant particles of chylomicrons and very low density lipoproteins measured postprandially appear to be responsible for the risk associated with hypertriglyceridemia. As the concentration of non-fasting triglycerides increases, the risk of myocardial infarction increases gradually up to five times.

Keywords: atherosclerosis risk; insulin resistance; liver; triglyceride

Received: November 3, 2019; Accepted: November 12, 2019; Published: December 1, 2019  Show citation

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Poledne R, Kovář J. Hypertriglyceridemia and atherosclerosis risk. Vnitr Lek. 2019;65(12):783-787. doi: 10.36290/vnl.2019.136.
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    References

    1. Gofman J, Strisower B, deLalla O et al. Index of coronary artery atherogenesis. Mod Med 1953; 21: 119-140.
    2. Zilversmit DB. A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins. Circ Res 1973; 33(6): 633-638. Dostupné z DOI: <http://dx.doi.org/10.1161/01.res.33.6.633>. Go to original source... Go to PubMed...
    3. Zilversmit DB. Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich remnant lipoproteins. Clin Chem 1995; 41(1): 153-158. Go to original source...
    4. Criqui MH, Heiss G, Cohn R et al. Plasma triglyceride level and mortality from coronary heart disease. NEJM 1993; 328(17): 1220-1225. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM199304293281702>. Go to original source... Go to PubMed...
    5. Austin MA. Plasma triglyceride and coronary heart disease. Arterioscler Thromb 1991; 11(1): 2-14. Dostupné z DOI: <http://dx.doi.org/10.1161/01.atv.11.1.2>. Go to original source... Go to PubMed...
    6. NIH Consensus conference. Triglyceride, high-density lipoprotein, and coronary heart disease. NIH Consensus Development Panel on Triglyceride, High-Density Lipoprotein, and Coronary Heart Disease. JAMA 1993; 269(4): 505-510.
    7. Young SG, Zechner R. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev 2013; 27(5): 459-484. Dostupné z DOI: <http://dx.doi.org/10.1101/gad.209296.112>. Go to original source... Go to PubMed...
    8. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 1996; 3(2): 213-219 Go to original source... Go to PubMed...
    9. Adiels M, Taskinen MR, Packard C et al. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 2006; 49(4): 755-765. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125-005-0125-z>. Go to original source... Go to PubMed...
    10. Havel RJ. George Lyman Duff memorial lecture. Role of the liver in atherosclerosis. Arteriosclerosis 1985; 5(6): 569-580. Dostupné z DOI: <http://dx.doi.org/10.1161/01.atv.5.6.569>. Go to original source... Go to PubMed...
    11. Langsted A, Freiberg JJ, Tybjaerg-Hansen A et al. Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up. J Intern Med 2011; 270(1): 65-75. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365-2796.2010.02333.x>. Go to original source... Go to PubMed...
    12. Kolovou GD, Mikhailidis DP, Kovar J et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement. Curr Vasc Pharmacol 2011; 9(3): 258-270. Dostupné z DOI: <http://dx.doi.org/10.2174/157016111795495549>. Go to original source... Go to PubMed...
    13. Hegele RA, Ginsberg HN, Chapman MJ et al. The polygenic nature of hypertriglyceridaemia: Implications for definition, diagnosis and management. Lancet Diabetes Endocrinol 2013; 2(8): 655-666. Dostupné z DOI: <http://dx.doi.org/10.1016/S2213-8587(13)70191-8>. Go to original source... Go to PubMed...

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