Vnitr Lek 2019, 65(7-8):520-523 | DOI: 10.36290/vnl.2019.090

Idiopathic inflammatory bowel disease and the first type of autoimmune form of pancreatitis: case report

Tomáš Kupka^1,*, Ivo Novotný², Lumír Kunovský^3,4, Magdalena Uvírová⁵, Martin Blaho¹, Jana Dvořáčková⁶, Petr Dítě¹

¹ Interní klinika LF OU a FN Ostrava

² Oddělení gastroenterologie Masarykova onkologického stavu, Brno

³ Interní gastroenterologická klinika LF MU a FN Brno, pracoviště Bohunice

⁴ Chirurgická klinika LF MU a FN Brno, pracoviště Bohunice

⁵ CGB laboratoř a.s., Ostrava

⁶ Ústav patologie LF OU a FN Ostrava

The autoimmune form of pancreatitis (AIP) is divided into the following two subtypes. The 1st subtype is characterized by the high presence of immunoglobulin G4 in the blood serum and tissue of some organs which are in the close connection to the so called IgG4 associated disorders. The typical diagnostic signs of AIP are the histomorphological changes. This type of AIP is more frequent than the 2^nd type with which has however some common histomorphological signs and mainly the positive response to the administered steroids used in the initial treatment. Whilst the 1^st type of AIP is typically connected to the disorders of various organs such are the biliary tract, salivary and lacrimal glands, retroperitoneal fibrosis, reins, prostate gland and the next ones, the 2^nd type of AIP is significantly connected to the inflammatory bowel disease only. Inflammatory bowel diseases are rarely present in the 1^st type of AIP on the contrary. In our case report we mention the first published observations performed in the Czech Republic when the 1^st type of AIP is succeeded by the inflammatory bowel disease - Crohn's disease.

Keywords: autoimmune pancreatitis; immunoglobulin G4; immunoglobulin G4 associated disorders; inflammatory bowel disease

Received: October 4, 2018; Accepted: February 3, 2019; Published: July 1, 2019  Show citation