Vnitr Lek 2018, 64(10):916-922 | DOI: 10.36290/vnl.2018.127

Transient elastography - role in the assessment of the liver disease development

Nikola Uzlová1,*, Nikola Mejzlíková1, Soňa Fraňková2, Pavla Libicherová1, David Nosek1, Ivan Rychlík1
1 I. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
2 Klinika hepatogastroenterologie IKEM, Praha

Transient elastography, an examination based on the liver stiffness measurement, is a method validated for the non-invasive liver fibrosis staging. This method was recently successfully introduced into routine clinical practice. In accordance with the global-wide screening of viral hepatitis (chronic viral hepatitis type B and type C) and with the increasing effectiveness of antiviral therapy, as well as with the increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the part of population requiring the care of hepatologists is certain to increase. Now more than ever we need a non-invasive, fast, safe, inexpensive and reliable method for evaluating patients with chronic liver disease. A new area of use of elastography appears to be used to measure the stiffness of the spleen as a prediction of the presence of esophageal varices or the stiffness (or rather fibrosis) of transplanted kidneys. The aim of this review is to provide a comprehensive view of transient elastography, its principles, advantages and pitfalls, including its use in everyday clinical practice.

Keywords: cirrhosis; fibrosis; renal allograft; transient elastography

Received: November 23, 2017; Accepted: March 19, 2018; Published: October 1, 2018  Show citation

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Uzlová N, Mejzlíková N, Fraňková S, Libicherová P, Nosek D, Rychlík I. Transient elastography - role in the assessment of the liver disease development. Vnitr Lek. 2018;64(10):916-922. doi: 10.36290/vnl.2018.127.
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    References

    1. Sandrin L, Oudry J, Bastard C et al. Non-Invasive Assessment of Liver Fibrosis by Vibration-Controlled Transient Elastography (Fibroscan®). Dostupné z WWW: <https://www.intechopen.com/books/liver-biopsy/non-invasive-assessment-of-liver-fibrosis-by-vibration-controlled-transient-elastography-fibroscan>.
    2. Sandrin L, Fourquet B, Hasquenoph JM et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29(12): 1705-1713. Go to original source... Go to PubMed...
    3. Boursier J, Zarski JP, de Ledinghen V et al. Determination of reliability criteria for liver stiffness evaluation by transient elastography. Multicentric Group from ANRS/HC/EP23 FIBROSTAR Studies. Hepatology 2013; 57(3): 1182-1191. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.25993>. Go to original source... Go to PubMed...
    4. Tapper EB, Castera L, Afdhal NH. FibroScan (Vibration-Controlled Transient Elastography): Where Does It Stand in the United States Practice. Clin Gastroenterol Hepatol 2015; 13(1): 27-36. Dostupné z DOI: <http://dx.doi.org/10.1016/j.cgh.2014.04.039>. Go to original source... Go to PubMed...
    5. Fraquelli M, Rigamonti C, Casazza G et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007; 56(7): 968-973. Dostupné z DOI: <http://dx.doi.org/10.1136/gut.2006.111302>. Go to original source... Go to PubMed...
    6. Castéra L, Foucher J, Bernard PH et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 2010; 51(3): 828-835. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.23425>. Go to original source... Go to PubMed...
    7. Lucidarme D, Foucher J, Le Bail B et al. Factors of accuracy of transient elastography (fibroscan) for the diagnosis of liver fibrosis in chronic hepatitis C. Hepatology 2009; 49(4): 1083-1089. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.22748>. Go to original source... Go to PubMed...
    8. Boursier J, Zarski JP, de Ledinghen V et al. Determination of reliability criteria for liver stiffness evaluation by transient elastography. Hepatology 2013; 57(3): 1182-1191. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.25993>. Go to original source... Go to PubMed...
    9. Mederacke I, Wursthorn K, Kirschner J et al. Food intake increases liver stiffness in patients with chronic or resolved hepatitis C virus infection. Liver Int 2009; 29(10): 1500-1506. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1478-3231.2009.02100.x>. Go to original source... Go to PubMed...
    10. Berzigotti A, De Gottardi A, Vukotic R et al. Effect of meal ingestion on liver stiffness in patients with cirrhosis and portal hypertension. PLoS One 2013; 8(3): e58742. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pone.0058742>. Go to original source... Go to PubMed...
    11. Arena U, Lupsor Platon M, Stasi C et al. Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution. Hepatology 2013; 58(1): 65-72. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.26343>. Go to original source... Go to PubMed...
    12. Friedrich-Rust M, Ong MF, Martens S et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134(4): 960-974. Dostupné z DOI: <http://dx.doi.org/10.1053/j.gastro.2008.01.034>. Go to original source... Go to PubMed...
    13. de Ledinghen V, Vergniol J. Transient elastography (FibroScan). Gastroenterol Clin Biol 2008; 32(6 Suppl 1): 58-67. Dostupné z DOI: <http://dx.doi.org/10.1016/S0399-8320(08)73994-0>. Go to original source... Go to PubMed...
    14. Pavlov CS, Casazza G, Nikolova D et al. Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease. Cochrane Database Syst Rev 2015; 1: CD010542. Dostupné z DOI: <http://dx.doi.org/10.1002/14651858.CD010542.pub2>. Go to original source...
    15. Wong VW, Vergniol J, Wong GL et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010; 51(2): 454-462. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.23312>. Go to original source... Go to PubMed...
    16. Chan HL, Wong GL, Choi PC et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat 2009; 16(1): 36-44. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365-2893.2008.01037.x>. Go to original source... Go to PubMed...
    17. Ehrmann J, Hůlek P. Hepatologie. 2. vyd. Grada: Praha 2014. EAN 24780214. ISBN 978-80-247-8021-4.
    18. Wong VW, Verginiol J, Wong GL et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010; 51(2): 454-462. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.23312>. Go to original source... Go to PubMed...
    19. Myers, RP, Pomier-Layrargues G, Kirsch R et al. Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology 2012; 55(1): 199-208. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.24624>. Go to original source... Go to PubMed...
    20. Wong VW, Verginiol J, Wong GL et al. Liver stiffness measurement using XL probe in patients with nonalcoholic fatty liver disease. Am J Gastroenterol 2012; 107(12): 1862-1871. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2012.331>. Go to original source... Go to PubMed...
    21. Trabut JB, Thépot V, Nalpas B et al. Rapid decline of liver stiffness following alcohol withdrawal in heavy drinkers. Alcohol Clin Exp Res 2012; 36(8): 1407-1411. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1530-0277.2012.01737.x>. Go to original source... Go to PubMed...
    22. Corpechot C, Carrat F, Poujol-Robert A et al. Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. Hepatology 2012; 56(1): 198-208. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.25599>. Go to original source... Go to PubMed...
    23. de Franchis R. [Baveno VI Faculty]. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol 2015; 63(3): 743-752. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2015.05.022>. Go to original source... Go to PubMed...
    24. Stefanescu H, Grigorescu M, Luspor M et al. Spleen stiffness measurement using fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients, J Gastroenterol Hepatol 2011; 26(1): 164-170. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1440-1746.2010.06325.x>. Go to original source... Go to PubMed...
    25. Bureau C, Metivier S, Peron JM et al. Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Aliment Pharmacol Ther 2008; 27(12): 1261-1268. Dostupné z DOI: <http://dx.doi.oerg/10.1111/j.1365-2036.2008.03701.x>. Go to original source... Go to PubMed...
    26. Kim SU, Lee JH, Kim DY et al. Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis. PLoS One 2012; 7(5): e36676. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pone.0036676>. Go to original source... Go to PubMed...
    27. Sporea I, Raţiu I, Sirli R et al. Value of transient elastography for the prediction of variceal bleeding. World J Gastroenterol 2011; 17(17): 2206-2210. Dostupné z DOI: <http://dx.doi.org/10.3748/wjg.v17.i17.2206>. Go to original source... Go to PubMed...
    28. Shi KQ, Fan YC, Pan ZZ et al. Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease. Liver Int 2013; 33(1): 62-71. Dostupné z DOI: <http://dx.doi.org/10.1111/liv.12003>. Go to original source... Go to PubMed...
    29. Adler M, Larocca L, Trovato FM et al. Evaluating the risk of hepatocellular carcinoma in patients with prominently elevated liver stiffness measurements by FibroScan: a multicentre study. HPB (Oxford) 2016; 18(8): 678-683. Dostupné z DOI: <http://dx.doi.org/10.1016/j.hpb.2016.05.005>. Go to original source... Go to PubMed...
    30. Hezode C, Castera L, Roudot-Thoraval F et al. Liver stiffness diminishes with antiviral response in chronic hepatitis C. Aliment Pharmacol Ther 2011; 34(6): 656-663. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365-2036.2011.04765.x>. Go to original source... Go to PubMed...
    31. [European Association for the Study of the Liver]. EASL Recommendations on Treatment of Hepatitis C 2016. J Hepatol 2017; 66(1): 153-194. Dostupné z DOI: Dostupné z DOI: <https://doi.org/10.1016/j.jhep.2016.09.001>. Go to original source... Go to PubMed...
    32. Kleiner DE, Brunt EM, Van Natta M et al. [Nonalcoholic Steatohepatitis Clinical Research Network]. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.20701>. Go to original source... Go to PubMed...
    33. Arndt R, Schmidt S, Loddenkemper Ch et al. Noninvasive evaluation of renal allograft fibrosis by transient elastography - a pilot study. Transpl Int 2010; 23(9): 871-877. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1432-2277.2010.01057.x>. Go to original source... Go to PubMed...
    34. Sommerer C, Scharf M, Seitz Ch et al. Assessment of renal allograft fibrosis by transient elastography. Transpl Int 2013, 26(5): 545-551. Dostupné z DOI: <http://dx.doi.org/10.1111/tri.12073>. Go to original source... Go to PubMed...

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