Vnitr Lek 2018, 64(4):437-440 | DOI: 10.36290/vnl.2018.062

Virilization as demonstration of hypertestosteronism by ovarian tumor: case report

Michal Mokáň¹, František Nehaj¹, Juraj Sokol^2,*, Peter Vaňuga³, Marián Mokáň¹

¹ I. interná klinika JLF UK a UNM, Martin, Slovenská republika

² Klinika hematológie a transfuziológie, Národné centrum hemostázy a trombózy, JLF UK a UNM, Martin, Slovenská republika

³ Národný endokrinologický a diabetologický ústav, n.o., Ľubochňa, Slovenská republika

Hypertestosteronism as part of hyperandrogenic states in women is generally defined as abundance of male hormones (in this case abundance of testosterone). Spectrum of clinical symptoms include menstrual disorders, amenorrhoea, different range of hirsutism and virilization. Statistically, most androgen secreting tumors are ovarian aetiology (testosterone secreting tumors located in suprarenal gland are very rare). This rare tumor may produce excess amounts of testosterone, as well as its precursor androstenedione. The highest incidence is between 20-40 years and in postmenopausal period. The treatment is essentially surgical; with gradual adjustment of the hormones.

Keywords: androgen secreting ovarian tumors; hyperandrogenic states; testosterone; virilisation

Received: April 16, 2017; Accepted: January 2, 2018; Published: April 1, 2018  Show citation