Vnitr Lek 2018, 64(4):375-379 | DOI: 10.36290/vnl.2018.055

Current treatment options in Maturity-Onset Diabetes of the Young

Ludmila Brunerová1,*, Jana Urbanová1, Jan Brož2
1 Diabetologické centrum II. interní kliniky 3. LF UK a FN Královské Vinohrady, Praha
2 Interní klinika 2. LF UK a FN Motol, Praha

The discovery of MODY (Maturity-Onset Diabetes of the Young) and the elucidation of its heritability enabled more precise clinical characteristics of different MODY subtypes and led to understanding that glucokinase MODY (GCK-MODY) is not associated with vascular complications in long term follow-up, whereas MODY of transcription factors (e.g. HNF1A-MODY) is in case of bad metabolic control connected with the acceleration of particularly microvascular complications. There is a strong evidence of the needlessness of any specific antidiabetic treatment in prognosticaly favourable GCK-MODY (except for the pregnancy). On the contrary, in MODY of transcription factors, including the most common one - HNF1A-MODY, the treatment, traditionally based on sulphonylurea derivatives (and after their failure on insulin) is required. Due to wider spectrum of available antidiabetic agents offering individualization of the treatment, the question of efficacy of other antidiabetic agents in MODY patients arises. This review article summarizes current knowledge of therapeutic options in patients with MODY.

Keywords: insulin; MODY; oral hypoglycemic drugs; treatment

Received: February 12, 2017; Accepted: January 4, 2018; Published: April 1, 2018  Show citation

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Brunerová L, Urbanová J, Brož J. Current treatment options in Maturity-Onset Diabetes of the Young. Vnitr Lek. 2018;64(4):375-379. doi: 10.36290/vnl.2018.055.
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