Vnitr Lek 2018, 64(2):197-208 | DOI: 10.36290/vnl.2018.029

Osteoporosis and quality of bone

Jan Štěpán
Revmatologický ústav, Praha

The risk of osteoporotic fracture is determined collectively by bone mineral density, bone mass, architecture and properties of the mineral and organic matrix composite. Changes in these distinct aspects of quality of bone with age, estrogen deficiency, diseases leading to increased risk of fracture and differential mode of action of antiresorptive and bone anabolic treatments have to be considered in clinical therapeutic strategies. In patients at high risk of low impact fracture, sequential therapy switching to antiresorptives after patients have an adequate response to 2 years teriparatide may be the optimal strategy of long term therapy.

Keywords: aging; bone quality; osteoporosis; prevention; therapy

Received: September 15, 2017; Accepted: November 19, 2017; Published: February 1, 2018  Show citation

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Štěpán J. Osteoporosis and quality of bone. Vnitr Lek. 2018;64(2):197-208. doi: 10.36290/vnl.2018.029.
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