Vnitr Lek 2018, 64(1):72-76 | DOI: 10.36290/vnl.2018.011

Remarks on biomarkers of cardiovascular risk

Janka Franeková1,2, Antonín Jabor1,2,*
1 Pracoviště laboratorních metod IKEM, Praha
2 Ústav laboratorní diagnostiky 3. LF UK, Praha

Authors describe state-of-the-art in the routine laboratory diagnostics of cardiovascular risk with special emphasis on metrology, traceability, external quality assessment, biological variation, and reference change value. While analytical quality of total cholesterol, triglycerides, glucose, and HbA1c is satisfactory, improvements are needed for HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, apolipoprotein B, Lp(a), and LpPLA2 measurements. Biological variation is a strong player in the lipid diagnostics, because reference change value is above 20 % for majority of biomarkers. Current methodology for the measurement of remnant cholesterol is far from optimum and standardization is therefore needed.

Keywords: biological variation; clinical chemistry; interpretation; lipid profile; metrology; remnant cholesterol

Received: November 19, 2017; Accepted: January 5, 2018; Published: January 1, 2018  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Franeková J, Jabor A. Remarks on biomarkers of cardiovascular risk. Vnitr Lek. 2018;64(1):72-76. doi: 10.36290/vnl.2018.011.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Nordestgaard BG, Langsted A, Mora S et al. Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Eur Heart J 2016; 37(25): 1944-1958. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehw152>. Go to original source... Go to PubMed...
    2. Soška V, Franeková J, Friedecký B et al. Společné stanovisko českých odborných společností ke konsensu European Atherosclerosis Society a European Federation of Clinical Chemistry and Laboratory Medicine k vyšetřování krevních lipidů a k interpretaci jejich hodnot. Klin Biochem Metab 2017; 25(1): 36-42.
    3. Langsted A, Freiberg JJ, Nordestgaard BG. Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction. Circulation 2008; 118(20): 2047-2056. Dostupné z DOI: <http://dx.doi.org/10.1161/CIRCULATIONAHA.108.804146>. Go to original source... Go to PubMed...
    4. Mora S, Rifai N, Buring JE et al. Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation 2008; 118(10): 993-1001. Dostupné z DOI: <http://dx.doi.org/10.1161/CIRCULATIONAHA.108.777334>. Go to original source... Go to PubMed...
    5. Franeková J, Jabor A, Soška V. Vliv standardní zátěže tukem na koncentrace triacylglycerolů a HDL cholesterolu. FONS 2016; 26(3)3: 22-24.
    6. Varbo A, Nordestgaard BG. Remnant lipoproteins. Curr Opin Lipidol 2017; 28(4): 300-307. Dostupné z DOI: <http://dx.doi.org/10.1097/MOL.0000000000000429>. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.