Vnitr Lek 2017, 63(11):861-874 | DOI: 10.36290/vnl.2017.159

Non-small cell lung cancer

Jana Skřičková*, Bohdan Kadlec, Ondřej Venclíček
Klinika nemocí plicních a TBC LF MU a FN Brno, pracoviště Bohunice

Non-small cell lung cancer (NSCLC) represents 80 % of diseases considering all patients with lung cancer. NSCLC comprises all histological types except for the small cell cancer. The treatment is chosen based on a clinical stage, morphological diagnosis and performance status of patients. In the low clinical stages a surgical solution is indicated. An alternative is radiotherapy. In some cases adjuvant treatment is indicated. In the locally advanced and metastatic stages chemotherapy and biological therapies are available and in recent time also immunotherapy is used. With regard to locally advanced diseases radiotherapy should also be considered.

Keywords: biological treatment; chemotherapy; immunotherapy; therapy; non-small cell lung cancer

Received: September 3, 2017; Accepted: September 26, 2017; Published: November 1, 2017  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Skřičková J, Kadlec B, Venclíček O. Non-small cell lung cancer. Vnitr Lek. 2017;63(11):861-874. doi: 10.36290/vnl.2017.159.
Download citation

References

  1. Dušek L, Malúšková D, Mužík J et al. Epidemiologie zhoubných nádorů plic, průdušnice a průdušek v České republice. Onkologická Revue 2016; 3(8): 7-11.
  2. Moulis M. Morfologická diagnostika karcinomu plic. In: Skřičková J, Kolek V et al. Základy moderní pneumoonkologie. Maxdorf: Praha 2012. ISBN 978-80-7345-298-8.
  3. Giroux DJ, Rami-Porta R, Chansky K et al. The IASLC Lung Cancer Staging Project: data elements for the prospective project. J Thorac Oncol 2009; 4(6): 679-683. Dostupné z DOI: <http://dx.doi.org/10.1097/JTO.0b013e3181a52370>. Go to original source... Go to PubMed...
  4. Skřičková J, Kolek V et al. Základy moderní pneumoonkologie. Max-dorf: Praha 2012. ISBN 978-80-7345-298-8.
  5. Skřičková J, Venclíček O, Kadlec B et al. Nemalobuněčný karcinom plic, Postgraduální medicína 2016; 18(Suppl 1): 21-27.
  6. Sculier J, Pand Moro-Sibilot D. First-and second-line therapy for advanced nonsmall cell lung cancer. Eur Respir J 2009; 33(4): 915-930. Dostupné z DOI: <http://dx.doi.org/10.1183/09031936.00132008>. Go to original source... Go to PubMed...
  7. Ginsberg RJ. Lung Cancer. BC Decker Hamilton: London 2002. ISBN 978-1550092950.
  8. Pallis AG, Gridelli C, Wedding U et al. Management of elderly patients with NSCLC; updated expert's opinion paper: EORTC Elderly Task Force, Lung Cancer Group and International Society for Geriatric Oncology. Ann Oncol 2014; 25(7): 1270-1283. Dostupné z DOI: <http://dx.doi.org/10.1093/annonc/mdu022>. Go to original source... Go to PubMed...
  9. Lien K, Georgsdottir S, Sivanathan L et al. Low-dose metronomic chemotherapy: a systematic literature analysis. Eur J Cancer 2013; 49(16): 3387-3395. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ejca.2013.06.038>. Go to original source... Go to PubMed...
  10. Yang JCH, Schuler M, Yamamoto N et al. LUX-Lung 3: a randomized, open-label, Phase III study of afatinib vs cisplatin/pemetrexed as 1st-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol 2012; 30(Suppl; abstr LBA7500). Go to original source... Go to PubMed...
  11. Wu Y, Zhou C, Hu C et al. LUX-Lung 6: A randomized, open-label, Phase III study of afatinib (A) vs. gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts.) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung. J Clin Oncol 2013; 31(15 Suppl): Abstr 8016. Dostupné z WWW: <http://ascopubs.org/doi/abs/10.1200/jco.2013.31.15_suppl.8016> Go to original source... Go to PubMed...
  12. Mok TS, Wu YI, Ahn MJ et al. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N Engl J Med 2017; 376(7): 629-640. Dostupné z DOI: http://dx.doi.org/10.1056/NEJMoa1612674>. Go to original source... Go to PubMed...
  13. Reck M. Nintedanib (BIBF 1120) plus docetaxel in NSCLC patients progressing after first-line chemotherapy: LUME Lung 1, a randomized, double-blind phase III trial. 2013 ASCO Annual Meeting. J Clin Oncol 2013; 31(Suppl): Abstr LBA8011. Dostupné z WWW: <https://meetinglibrary.asco.org/record/83807/abstract>. Go to original source...
  14. Hanna N. LUME-Lung 2: A multicentre, randomized, double-blind, Phase III study of nintedanib plus pemetrexed vs. placebo plus pemetrexed in patients with advanced non-squamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. ASCO Annual Meeting, Chicago, June 2, 2013. J Clin Oncol 2013; 31(Suppl): Abstr 8034. Dostupné z WWW: <https://meetinglibrary.asco.org/record/81165/abstract>. Go to original source... Go to PubMed...
  15. Perol M, Ciuleanu TE, Arrieta O et al. REVEL: A randomized, double-blind, phase III study of docetaxel (DOC) and ramucirumab (RAM; IMC-1121B) versus DOC and placebo (PL) in the second-line treatment of stage IV non-small cell lung cancer (NSCLC) following disease progression after one prior platinum-based therapy. J Clin Oncol 2014; 32:5S(Suppl): Abstr LBA8006. Dostupné z WWW: <https://meetinglibrary.asco.org/record/92344/abstract>. Go to original source...
  16. Shaw AT, Solomon B. Targeting anaplastic lymphoma kinase in lung cancer. Clin Cancer Res 2011; 17(8): 2081-2086. Dostupné z DOI: <http://dx.doi.org/10.1158/1078-0432.CCR-10-1591>. Go to original source... Go to PubMed...
  17. Shaw AT, Kim DW, Mehra R et al. Ceritinib in ALK-Rearranged Non-Small-Cell Lung Cancer. N Engl J Med 2014 March 27; 370(13): 1189-1197. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1311107>. Go to original source... Go to PubMed...
  18. Paz-Ares L, de Marinis F, Dediu M et al. Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial. Lancet Oncol 2012; 13(3): 247-255. Dostupné z DOI: <http://dx.doi.org/10.1016/S1470-2045(12)70063-3>. Go to original source... Go to PubMed...
  19. Hirsch FR, Spreafico A, Novello S et al. The prognostic and predictive role of histology in advanced non-small cell lung cancer. J Thorac Oncol 2008; 3(12): 1468-1481. Dostupné z DOI: <http://dx.doi.org/10.1097/JTO.0b013e318189f551>. Go to original source... Go to PubMed...
  20. Kelly RJ, Gulley JL, Giaccone G. Targeting the immune system in non-small cell lung cancer: bridging the gap between promising concept and therapeutic reality. Clin Lung Cancer 2010; 11(4): 228-237. Dostupné z DOI: <http://dx.doi.org/10.3816/CLC.2010.n.029>. Go to original source... Go to PubMed...
  21. Fong L, Small EJ. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol 2008; 26(32): 5275-5283. <http://dx.doi.org/10.1200/JCO.2008.17.8954>. Go to original source... Go to PubMed...
  22. Al-Shibli KI, Donnem T, Al-Saad S et al. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 2008; 14(16): 5220-5227. Dostupné z DOI: <http://dx.doi.org/10.1158/1078-0432.CCR-08-0133>. Go to original source... Go to PubMed...
  23. Kawai O, Ishii G, Kubota K et al. Predominant infiltration of macrophages and CD8+ T cells in cancer nests is a significant predictor of survival in stage IV non-small cell lung cancer. Cancer 2008; 113(6): 1387-1395. Dostupné z DOI: <http://dx.doi.org/10.1002/cncr.23712>. Go to original source... Go to PubMed...
  24. Lynch TJ, Bondarenko I, Luft A et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small cell lung cancer: results from a randomized, double-blind, multicenter Phase II study. J Clin Oncol 2012; 30(17)(2046-2054. <http://dx.doi.org/10.1200/JCO.2011.38.4032>. Go to original source... Go to PubMed...
  25. Maker AV, Attia P, Rosenberg SA. Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade. J Immunol 2005; 175(11): 7746-7754. Go to original source... Go to PubMed...
  26. Spigel DR, Reckamp KL, Rizvi N et al. A phase III study (CheckMate 017) of nivolumab (NIVO; anti-programmed death-1 (PD-1)) vs docetaxel (DOC) in previously treated advanced or metastatic squamous (SQ) cell non-small cell lung cancer (NSCLC). J Clin Oncol 2015; 33(18 Suppl): Abstr 8009. Dostupné z DOI: <http://dx.doi.org/10.1200/jco.2015.33.18_suppl.lba109>. Go to original source...
  27. Reck M, Rodríguez-Abreu D, Robinson AG et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med 2016; 375(19): 1823-1833. Go to original source... Go to PubMed...
  28. Garassino MC, Rizvi N, Besse B et al. Atezolizumab as 1L therapy for advanced NSCLC in PD-L1-selected patients: Updated ORR, PFS and OS data from the BIRCH study. 2016 World Conference on Lung Cancer. Abstract OA03.02. Presented December 5, 2016. J Thorac Oncol 2017; 12(1 Suppl): S251-S252. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jtho.2016.11.239>. Go to original source...
  29. Schmerl RA. Toxicity of checkpoint inhibitors. Chin Clin Oncol 2014; 3(3): 31. Dostupné z DOI: <http://dx.doi.org/10.3978/j.issn.2304-3865.2014.08.03>.
  30. Lakomý R., Poprach A. Nežádoucí účinky moderní imunoterapie a jejich řešení v klinické praxi. Klin Onkol 2015; 28(Suppl 4): 4S103-4S114. Go to original source...
  31. Mok TS, Wu YL, Ahn MJ et al. Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. N Engl J Med 2017; 376(7): 629-640. Dostupné z DOI: <doi: 10.1056/NEJMoa1612674>. Go to original source... Go to PubMed...
  32. Papadimitrakopoulou VA, Wu YL, Ahn MJ et al. Randomized Phase III Study of Osimertinib vs Platinum-Pemetrexed for EGFR T790M-Positive Advanced NSCLC (AURA3). PL03.03. J Thorac Oncol 2017; 12(1 Suppl): S5-S6. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jtho.2016.11.006>. Go to original source...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.