Vnitr Lek 2017, 63(10):712-716 | DOI: 10.36290/vnl.2017.141

Metabolic syndrome and the role of the polypill in the prevention of its complications

Hana Rosolová
Centrum preventivní kardiologie II. interní kliniky LF UK a FN Plzeň

The first mention concerning occurrence of cardiometabolic risk factors together appeared 100 years ago. Metabolic syndrome brings 5times higher risk for type 2 diabetes development and 2-3times higher cardiovascular (CV) risk in comparison to the subjects without that syndrome. Healthy life habits and rational pharmacotherapy of hypertension, dyslipidemia and hyperglycemia represent an effective way for high cardiometabolic risk reduction. The problem are patient's low adherence and persistence to the recommendation and pharmacotherapy. Right now polypill (fixed combination of antihypertensives and lipid modifying drugs) are solving in the CV disease prevention. However sufficient evidence exist in the secondary CV prevention, some gap of knowledge is persisting in the primary CV prevention. Right combination of drugs in the polypill might be a suitable solving of CV disease and diabetes prevention for the patients with metabolic syndrome.

Keywords: cardiometabolic risk; cardiovascular disease prevention; metabolic syndrome; polypill

Received: September 19, 2017; Accepted: September 27, 2017; Published: October 1, 2017  Show citation

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Rosolová H. Metabolic syndrome and the role of the polypill in the prevention of its complications. Vnitr Lek. 2017;63(10):712-716. doi: 10.36290/vnl.2017.141.
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