Vnitr Lek 2016, 62(9):746-750

Oral anticoagulants for primary and secondary prevention of venous thromboembolism

Peter Gavorník*, Andrej Dukát, Ľudovít Gašpar, Gabriela Gubo, Naďa Hučková
Angiologická sekcia Slovenskej lekárskej komory, Bratislava, Slovenská republika

Until recently, vitamin K antagonists (VKA; predominantly warfarin) were the only oral anticoagulants for primary and secondary prevention of venous thromboembolism. Prevention and therapy with novel, direct, non-VKA oral anticoagulant agents (NOACs; DOACs: dabigatran, rivaroxaban, apixaban, edoxaban), have recently become available as an alternative to VKA. NOACs have been shown to be non-inferior or superior to VKA in clinical trials. Available results suggest that real world safety of NOACs is mostly consistent with results observed in clinical trials. The most effective method is triple simultaneous prevention of venous thromboembolism (pharmacokineziomechanophlebothromboemboloprophylaxis).

Keywords: oral anticoagulants; NOAC, DOAC; thromboprophylaxis; venous thromboembolism; VKA

Received: June 19, 2016; Published: September 1, 2016  Show citation

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Gavorník P, Dukát A, Gašpar Ľ, Gubo G, Hučková N. Oral anticoagulants for primary and secondary prevention of venous thromboembolism. Vnitr Lek. 2016;62(9):746-750.
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