Vnitr Lek 2016, 62(4):299-303

Chronic kidney diseases, metformin and lactic acidosis

Zoltán Borbély^1,2

¹ Klinika vnútorného lekárstva I. FNsP Nové Zámky, Slovenská republika

² Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety, Bratislava, Slovenská republika

Chronic kidney disease and diabetes mellitus represent a worldwide public health problem. The incidence of these diseases is gradually growing into epidemic proportions. In many cases they occur simultaneously, what leads to increased morbidity and mortality among the affected patients. The majority of the patients treated for diabetes mellitus are unaware of the presence of renal insufficiency. Vascular hypertrophy and diabetic kidney disease in patients with type 2 diabetes are the most common causes of kidney failure in countries with advanced healthcare systems. Metformin is a basic drug used for the treatment of type 2 diabetes mellitus. It is excreted in an unchanged form by the kidneys. When administered to patients with renal insufficiency, sepsis, dehydration or after the parenteral administration of iodinated contrast agents, metformin can cause lactic acidosis, which is also associated with an increased mortality rate.

Keywords: diabetes mellitus; chronic kidney disease; lactic acidosis; metformin

Received: September 18, 2015; Accepted: November 9, 2015; Published: April 1, 2016  Show citation