Vnitr Lek 2015, 61(6):597-598

Application of stem cells in orthopedics

Pavel Žák
IV. interní hematologická klinika LF UK a FN Hradec Králové, přednosta doc. MUDr. Pavel Žák, Ph.D.

Regeneration of articular cartilage remains a major challenge in orthopaedics. Cell-based therapies (with chondrocyte and MSCs - mesenchymal stem cells) to augment cartilage repair have received considerable interest during recent years. Adipose MSCs have been used in the Czech Republic for osteoarthritis therapy, despite not being recommended by the Czech Orthopaedic Association. This lecture reviews the studies and their level of evidence for orthopaedic routine therapy of osteoarthritis.

Keywords: mesenchymal stem cells; osteoarthritis

Received: January 5, 2015; Accepted: February 15, 2015; Published: June 1, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Žák P. Application of stem cells in orthopedics. Vnitr Lek. 2015;61(6):597-598.
Download citation

References

  1. Izadpanath R, Kaushal D, Kriedt C et al. Long-term in vitro expansion alter the biology of adult mesenchymal stem cells. Cancer Res 2008; 68(11): 4229-4238. Go to original source... Go to PubMed...
  2. Centeno CJ, Busse D, Kisiday J et al. Increased knee cartilage volume in degenerative joint disease usány percutaneously implanted autologous mesenchymal stem cells. Pain Physician 2008; 11(3): 343-353. Go to original source... Go to PubMed...
  3. Centeno CJ, Kisiday J, Freeman M et al. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer. Pain Physician 2006; 9(3): 253-256. Go to PubMed...
  4. Vangsness CT, Farr J, Boyd J et al. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial menisectomy. J Bone Point Surg Am 2014; 96(2): 90-98. Go to original source... Go to PubMed...
  5. Peeters CM, Leijs MJ, Reijman M et al. Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: A systematic literature review. Osteoarthritis Cartilage 2013; 21(10): 1465-1473. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.