Vnitr Lek 2015, 61(5):398-400

The effect of adding phytosterol to hypolipidemic therapy with statins on the size of lipoprotein particles in patients with very high cardiovascular risk

Andrej Dukát^1,*, Ján Gajdošík², Peter Sabaka¹, Dávid Baláž¹, Lucia Mistríková³, Stanislav Oravec¹, Peter Gavorník¹, Ľudovít Gašpar¹

¹ II. interná klinika LF UK a UN Bratislava, Slovenská republika, prednosta doc. MUDr. Ľudovít Gašpar, CSc.

² Neštátna ambulancia pre dospelých v Nových Zámkoch, Slovenská republika, vedúci pracovník prof. MUDr. Ján Gajdošík, CSc.

³ Východoslovenský ústav srdcových a cievnych chorôb, a.s., Košice, Slovenská republika, predseda predstavenstva MUDr. František Sabol, PhD.

Despite significant improvement in the diagnosis and therapy of cardiovascular diseases their global risk and proportion of their clinical forms remains very high. Still the large part of the patients cannot reach the estimated target lipid levels despite statin therapy. Low adherence to preventive programmes with physical training and diet leads to progression of the pathological process of atherothrombosis. One possible therapeutic approach could be the combined hypolipidemic treatment. In this context we followed-up the size of lipoprotein particles among very high risk patients on statin monotherapy, where phytosterole was added. Lipoprotein profile among very high risk patients during combined therapy lead to improvement and therefore may contribute to lowering of their residual risk.

Keywords: cardiovascular pharmacotherapy; phytosterols; hypolipidemics; lipoproteins; statins

Received: February 28, 2015; Accepted: April 8, 2015; Published: May 1, 2015  Show citation