Vnitr Lek 2014, 60(5-6):467-473

Risk factors and progression predictors of Barrett's oesophagus to adenocarcinoma

Pavel Svoboda1,2,*, Petr Dítě1,2, Pavel Klvaňa1,2, Tomáš Kupka2, Martina Bojková2, Jana Žmolíková3,4,5, Irena Urbanovská3,4,6, Magdalena Uvírová3,4,6, Petr Buzrla7,8, Jana Dvořáčková5,7,8
1 Katedra interních oborů LF OU Ostrava, vedoucí katedry MUDr. Ivo Valkovský, Ph.D.
2 Interní klinika LF OU a FN Ostrava, přednosta doc. MUDr. Arnošt Martínek., CSc.
3 Vědecký a výzkumný institut Agel, pobočka Ostrava-Vítkovice, CGB laboratoř, ředitelka společnosti RNDr. Magdalena Uvírová
4 Katedra biomedicínských oborů LF OU Ostrava, vedoucí katedry doc. RNDr. Kristian Šafarčík, Ph.D.
5 Ústav biologie LF UP Olomouc, přednosta ústavu doc. RNDr. Vladimír Divoký, Ph.D.
6 Ústav molekulární a translační medicíny LF UP Olomouc, ředitel doc. MUDr. Marián Hajdúch, Ph.D.
7 Ústav patologie LF OU, vedoucí ústavu doc. MUDr. Jaroslav Horáček, CSc.
8 Ústav patologie FN Ostrava, vedoucí ústavu doc. MUDr. Jana Dvořáčková, Ph.D.

Gastroesophageal reflux disease is a quite common disorder, and the condition affects some 40 per cent of population in the course of their lifetime. Fortunately, about half of the patients examined due to clear symptoms do not manifest macroscopic damage of the oesophageal mucosa, and serious endoscopic findings (Barrett's oesophagus) are observed in only a small percentage of patients (10%). Barrett's oesophagus is a serious complication - precancerous condition with a 30-fold higher risk of development of oesophageal adenocarcinoma when compared with patients without this condition. The article presents risk factors and predictors of progression of the Barrett's oesophagus into the stage of adenocarcinoma. The main risk factors associated with oesophageal adenocarcinoma are male sex, white race, gastroesophageal reflux.

Keywords: aetiology; Barrett's oesophagus; oesophageal adenocarcinoma; reflux

Received: December 18, 2013; Accepted: March 18, 2014; Published: May 1, 2014  Show citation

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Svoboda P, Dítě P, Klvaňa P, Kupka T, Bojková M, Žmolíková J, et al.. Risk factors and progression predictors of Barrett's oesophagus to adenocarcinoma. Vnitr Lek. 2014;60(5-6):467-473.
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