Vnitr Lek 2014, 60(5-6):437-441

Heart failure - can be treated by affecting cardiac metabolism?

Ján Murín*, Miroslav Pernický, Soňa Kiňová
I. interná klinika LF UK a UN Bratislava, Slovenská republika, prednostka doc. MUDr. Soňa Kiňová, CSc.

Chronic heart failure is a disease of epidemic extent and has a high mortality and morbidity. Etiology is multifactorial, but the issue is that heart does not have "enough fuel" to produce energy for its work or available fuel can't be properly utilized. Components of cardiac energy metabolism are substrate utilization, oxidative phosphorylation and ATP (adenosine triphosphate) transfer and utilization. The aim of article is to present the function of heart metabolism and how "metabolic dysfunction" contributes to heart failure. Perhaps, drug effect on heart metabolism is an approach to treatment of chronic heart failure.

Keywords: cardiac energy metabolism; energy metabolism regulators; heart failure; treatment of heart failure

Received: December 10, 2013; Accepted: January 28, 2014; Published: May 1, 2014  Show citation

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Murín J, Pernický M, Kiňová S. Heart failure - can be treated by affecting cardiac metabolism? Vnitr Lek. 2014;60(5-6):437-441.
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